Role of gut microbiota in identification of novel TCM-derived active metabolites.
Tzu-Lung Lin,Chia-Chen Lu,Wei-Fan Lai,Ting-Shu Wu,Ting-Shu Wu,Jang-Jih Lu,Young-Mao Chen,Chi-Meng Tzeng,Hongtao Liu,Hong Wei,Hsin-Chih Lai +10 more
TLDR
Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years, but owing to a lack of formal scientific validation, the absence of information regarding the mechanisms underlying TCMs restricts their application.Abstract:
Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing to a lack of formal scientific validation, the absence of information regarding the mechanisms underlying TCMs restricts their application. After oral administration, TCM herbal ingredients frequently are not directly absorbed by the host, but rather enter the intestine to be transformed by gut microbiota. The gut microbiota is a microbial community living in animal intestines, and functions to maintain host homeostasis and health. Increasing evidences indicate that TCM herbs closely affect gut microbiota composition, which is associated with the conversion of herbal components into active metabolites. These may significantly affect the therapeutic activity of TCMs. Microbiota analyses, in conjunction with modern multiomics platforms, can together identify novel functional metabolites and form the basis of future TCM research.read more
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Effects of a probiotic-fermented herbal blend on the growth performance, intestinal flora and immune function of chicks infected with Salmonella pullorum.
TL;DR: PF treatment prevented death, improved growth performance, regulated intestinal flora and enhanced immune ability of newborn broilers infected with S. pullorum, and significantly improved the development of the thymus and bursa in S.pullorum-infected chicks.
Journal ArticleDOI
Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses
TL;DR: In this paper, the authors discuss the possibility that indigo, polysaccharides, colchicine, and ginsenosides can act locally in the gut or liver to activate xenobiotic defense pathways that trigger beneficial systemic effects on the immune system.
Journal ArticleDOI
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
TL;DR: In this article, the effects of three phytosterols (DLA, DL, and DP) on the anti-breast tumor effects of sweet potato in MCF-7 xenograft nude mice were evaluated.
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Gardenia jasminoides Ellis polysaccharide ameliorates cholestatic liver injury by alleviating gut microbiota dysbiosis and inhibiting the TLR4/NF-κB signaling pathway.
Suli Fang,Tianming Wang,Yuanyuan Li,Haoyu Xue,Juan Zou,Jin-da Cai,Rong Shi,Jiasheng Wu,Yueming Ma +8 more
TL;DR: In this article , the effect of G. jasminoides Ellis polysaccharide (GPS) on liver injury in an ANIT-induced cholestatic mouse model and the associated molecular mechanisms were investigated.
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Tongxinluo May Alleviate Inflammation and Improve the Stability of Atherosclerotic Plaques by Changing the Intestinal Flora
Yan Qin,Wenzhao Liu,Xuefang Yan,Chen Zhang,Chunmei Zhang,Lingxin Liu,Xuehui Zheng,Mengying Suo,Yun Ti,Mei Ni,Meng Zhang,Peili Bu +11 more
TL;DR: Tongxinluo can improve plaque stability and reduce inflammation in atherosclerotic rabbits, which may be achieved by modulating intestinal flora and intestinal metabolism.
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