Journal ArticleDOI
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.
Fariyal Ahmed,Dennis E. Discher +1 more
Reads0
Chats0
TLDR
With all compositions, in both 100 nm and giant vesicles, the average release time reflects a highly quantized process in which any given vesicle is either intact and retains its encapsulant, or is porated and slowly disintegrates.About:
This article is published in Journal of Controlled Release.The article was published on 2004-04-16. It has received 638 citations till now. The article focuses on the topics: Controlled release & Polymersome.read more
Citations
More filters
Stimuli-Responsive Polymers: Design and Applications
TL;DR: A review of the state-of-the art of the design and applications of various biocompatible stimuliresponsive polymers and their structure-property relationships is given in this article.
Journal ArticleDOI
A Critical Analysis of Polymersome Therapeutics: From Laboratory to Large-Scale Production
TL;DR: Beatriz Nogueira Messias de Miranda as mentioned in this paper, Wesley Luzetti Fotoran, Gerhard Wunderlich, Emanuel Carrilho, and Adriano Marim de Oliveira.
Journal ArticleDOI
Application of Polymeric Micelles for Cancer Treatment: A Review
TL;DR: In this paper , the authors discuss dual or multi-stimuli-sensitive polymeric micelles that are under high research nowadays, dictating a more novel and efficient way of cancer treatments and clinical practices.
Dissertation
Stabilization and comparison of manufacturing technologies for production of nano-crystalline suspensions
TL;DR: In this article, the authors present a method for the stabilisation and fabrication of nano-crystallines based on the faible taille of nanoparticules, which permet d'ameliorer significativement the biodisponibilite des medicaments and faciliter leur administration par voie parenterale.
Patent
Polymersomes inhibiteurs de metap-2 destinés à l'administration thérapeutique
TL;DR: In this paper, a modification of MetAP-2 has been proposed, which concerne des inhibiteurs de MetAP2 and des compositions et formulations of ces derniers, and en particulier des compositions and formulations d'inhibiteurs of metap-2.
References
More filters
Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
Journal ArticleDOI
Block Copolymers—Designer Soft Materials
TL;DR: The Knitting Pattern as mentioned in this paper is a block copolymer that was discovered by Reimund Stadler and his coworkers and reflects a delicate free-energy minimization that is common to all blockcopolymer materials.
Journal Article
Polymer vesicles : Materials science: Soft surfaces
Dennis E. Discher,Adi Eisenberg +1 more
TL;DR: Future applications of polymer vesicles will rely on exploiting unique property-performance relations, but results to date underscore the fact that biologically derived vesicle are but a small subset of what is physically and chemically possible.
Journal ArticleDOI
Biodegradation and biocompatibility of PLA and PLGA microspheres
TL;DR: This chapter is a critical review of biodegradation, biocompatibility and tissue/material interactions, and selected examples of PLA and PLGA microsphere controlled release systems, and emphasis is placed on polymer and microSphere characteristics which modulate the degradation behaviour and the foreign body reaction to the microspheres.
Journal ArticleDOI
Polymersomes: tough vesicles made from diblock copolymers.
Bohdana M. Discher,You-Yeon Won,David S. Ege,James C. Lee,Frank S. Bates,Dennis E. Discher,Daniel A. Hammer +6 more
TL;DR: The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry, and both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements.