Journal ArticleDOI
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.
Fariyal Ahmed,Dennis E. Discher +1 more
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TLDR
With all compositions, in both 100 nm and giant vesicles, the average release time reflects a highly quantized process in which any given vesicle is either intact and retains its encapsulant, or is porated and slowly disintegrates.About:
This article is published in Journal of Controlled Release.The article was published on 2004-04-16. It has received 638 citations till now. The article focuses on the topics: Controlled release & Polymersome.read more
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Mimicking the cell membrane with block copolymer membranes
TL;DR: The domain of synthetic membranes based on amphiphilic copolymers beginning with their generation and up to their applications in medicine, the food industry, and technology is presented.
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Folate receptor-targeted multimodal polymersomes for delivery of quantum dots and doxorubicin to breast adenocarcinoma: In vitro and in vivo evaluation.
Mona Alibolandi,Khalil Abnous,Fatemeh Sadeghi,Hossein Hosseinkhani,Mohammad Ramezani,Farzin Hadizadeh +5 more
TL;DR: In vivo experiments including whole organ tissue-homogenate analysis and organ fluorescence microscopy imaging of BALB/c mice bearing 4T1 breast adenocarcinoma showed that the folate receptor-targeted QD encapsulated NPs accumulate at tumor sites 6h following intravenous injection, illustrating a high potential of the prepared targeted theranostic nanoplatform in the treatment and imaging of breast cancer.
Journal Article
Nanoshells and nanotubes from block copolymers
TL;DR: In this paper, the authors explored the use of block copolymer vesicles and tubules for encapsulation, targeted drug delivery, and templating of inorganic materials.
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High loading of hydrophilic/hydrophobic doxorubicin into polyphosphazene polymersome for breast cancer therapy.
TL;DR: In vivo investigation in growth inhibition of MCF-7 xenograft tumors in nude mice demonstrated that PEP polymersomes could enhance life safety without compromise of therapeutic efficacy, especially DOX·HCl loaded delivery system.
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Polymersomes for Therapeutic Delivery of Protein and Nucleic Acid Macromolecules: From Design to Therapeutic Applications.
TL;DR: This review will highlight the key factors in design, development, and improved performance of these vesicles for macromolecular delivery and the recent progress made towards pre-clinical application.
References
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Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
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Block Copolymers—Designer Soft Materials
TL;DR: The Knitting Pattern as mentioned in this paper is a block copolymer that was discovered by Reimund Stadler and his coworkers and reflects a delicate free-energy minimization that is common to all blockcopolymer materials.
Journal Article
Polymer vesicles : Materials science: Soft surfaces
Dennis E. Discher,Adi Eisenberg +1 more
TL;DR: Future applications of polymer vesicles will rely on exploiting unique property-performance relations, but results to date underscore the fact that biologically derived vesicle are but a small subset of what is physically and chemically possible.
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Biodegradation and biocompatibility of PLA and PLGA microspheres
TL;DR: This chapter is a critical review of biodegradation, biocompatibility and tissue/material interactions, and selected examples of PLA and PLGA microsphere controlled release systems, and emphasis is placed on polymer and microSphere characteristics which modulate the degradation behaviour and the foreign body reaction to the microspheres.
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Polymersomes: tough vesicles made from diblock copolymers.
Bohdana M. Discher,You-Yeon Won,David S. Ege,James C. Lee,Frank S. Bates,Dennis E. Discher,Daniel A. Hammer +6 more
TL;DR: The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry, and both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements.