Journal ArticleDOI
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.
Fariyal Ahmed,Dennis E. Discher +1 more
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TLDR
With all compositions, in both 100 nm and giant vesicles, the average release time reflects a highly quantized process in which any given vesicle is either intact and retains its encapsulant, or is porated and slowly disintegrates.About:
This article is published in Journal of Controlled Release.The article was published on 2004-04-16. It has received 638 citations till now. The article focuses on the topics: Controlled release & Polymersome.read more
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Enzymes containing porous polymersomes as nano reaction vessels for cascade reactions
Suzanne M. Kuiper,Madhavan Nallani,Dennis M. Vriezema,Jeroen J. L. M. Cornelissen,Jan C. M. van Hest,Roeland J. M. Nolte,Alan E. Rowan +6 more
TL;DR: The encapsulation and protection of glucose oxidase and horse radish peroxidase in PS-PIAT polymersomes is reported on and the demonstrated concept allows for further application in other enzymatic cascade reactions, bio-organic hybrid systems and biosensing devices.
Journal ArticleDOI
In Vitro and in Vivo Release of Albumin Using a Biodegradable MPEG-PCL Diblock Copolymer as an in Situ Gel-Forming Carrier
Hoon Hyun,Yu Han Kim,In Bum Song,Jung Won Lee,Moon Suk Kim,Gilson Khang,Kinam Park,Hai Bang Lee +7 more
TL;DR: The present findings show that MPEG-PCL diblock copolymer solutions are thermo-responsive and maintain their structural integrity under physiological conditions, indicating that they are suitable for use as injectable drug carriers.
Journal ArticleDOI
Nanoshells and nanotubes from block copolymers
TL;DR: The stability and toughness of block copolymer vesicles are enhanced compared to those formed by low molar mass amphiphiles, which leads to numerous potential applications in encapsulation, in targeted drug delivery, templating of inorganic materials and many others.
Journal ArticleDOI
Epithelial cell adhesion molecule aptamer conjugated PEG-PLGA nanopolymersomes for targeted delivery of doxorubicin to human breast adenocarcinoma cell line in vitro.
TL;DR: EpCAM-targeted PEG-PLGA nanopolymersomes will lead to an improved therapeutic index of doxorubicin to EpCAM positive cancer cells, and were significantly more cytotoxic toward EpCam-positive tumor cells (MCF-7) than non- targeted nanopolymeromes.
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Polymersome-based drug-delivery strategies for cancer therapeutics.
Tayebeh Anajafi,Sanku Mallik +1 more
TL;DR: In this review, recent developments for biocompatible and biodegradable polymersomes, including the design of intelligent, targeted, and stimuli-responsive vesicles are summarized.
References
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Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
Journal ArticleDOI
Block Copolymers—Designer Soft Materials
TL;DR: The Knitting Pattern as mentioned in this paper is a block copolymer that was discovered by Reimund Stadler and his coworkers and reflects a delicate free-energy minimization that is common to all blockcopolymer materials.
Journal Article
Polymer vesicles : Materials science: Soft surfaces
Dennis E. Discher,Adi Eisenberg +1 more
TL;DR: Future applications of polymer vesicles will rely on exploiting unique property-performance relations, but results to date underscore the fact that biologically derived vesicle are but a small subset of what is physically and chemically possible.
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Biodegradation and biocompatibility of PLA and PLGA microspheres
TL;DR: This chapter is a critical review of biodegradation, biocompatibility and tissue/material interactions, and selected examples of PLA and PLGA microsphere controlled release systems, and emphasis is placed on polymer and microSphere characteristics which modulate the degradation behaviour and the foreign body reaction to the microspheres.
Journal ArticleDOI
Polymersomes: tough vesicles made from diblock copolymers.
Bohdana M. Discher,You-Yeon Won,David S. Ege,James C. Lee,Frank S. Bates,Dennis E. Discher,Daniel A. Hammer +6 more
TL;DR: The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry, and both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements.