Journal ArticleDOI
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.
Fariyal Ahmed,Dennis E. Discher +1 more
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TLDR
With all compositions, in both 100 nm and giant vesicles, the average release time reflects a highly quantized process in which any given vesicle is either intact and retains its encapsulant, or is porated and slowly disintegrates.About:
This article is published in Journal of Controlled Release.The article was published on 2004-04-16. It has received 638 citations till now. The article focuses on the topics: Controlled release & Polymersome.read more
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Biohybrid Polymer Capsules
Stijn F. M. van Dongen,Hans-Peter M. de Hoog,Ruud J. R. W. Peters,Madhavan Nallani,Roeland J. M. Nolte,Jan C. M. van Hest +5 more
TL;DR: An overview of the wide range of polymer-based capsules that have been constructed from synthetic and biological building blocks or from Biological building blocks that are taken out of their natural environment, using both hyperbranched and self-assembly approaches was reviewed.
Journal ArticleDOI
Bioceramics: From Bone Regeneration to Cancer Nanomedicine
TL;DR: Research on biomaterials has been growing in the last few years due to the clinical needs in organs and tissues replacement and regeneration and in addition, cancer nanomedicine has recently appeared as an effective means to combine nanotechnology developments towards a clinical application.
Journal ArticleDOI
Polymersome carriers: from self-assembly to siRNA and protein therapeutics.
David A. Christian,Shenshen Cai,Diana M. Bowen,Younghoon Kim,J. David Pajerowski,Dennis E. Discher +5 more
TL;DR: Robustness together with recently described mechanisms for controlled breakdown of degradable polymersomes as well as escape from endolysosomes suggests that polymersome might be usefully viewed as having structure/property/function relationships somewhere between lipid vesicles and viral capsids.
Journal ArticleDOI
Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation.
Fariyal Ahmed,Refika I. Pakunlu,Goundla Srinivas,Aaron K. Brannan,Frank S. Bates,Michael L. Klein,Tamara Minko,Dennis E. Discher +7 more
TL;DR: Load, delivery, and cytosolic uptake of drug mixtures from degradable polymersomes are shown to exploit both the thick membrane of these block copolymer vesicles and their aqueous lumen as well as pH-triggered release within endolysosomes to disrupt lipid membranes and thereby enhance drug activity.
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PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application.
TL;DR: This review discusses state‐of‐the‐art nanomedicines based on PEG‐PCL that have been investigated in a preclinical setting and highlights recent therapeutic applications investigated in vitro and in vivo using advanced systems such as triggered release, multi‐component therapies, theranostics, or gene delivery systems.
References
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Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
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Block Copolymers—Designer Soft Materials
TL;DR: The Knitting Pattern as mentioned in this paper is a block copolymer that was discovered by Reimund Stadler and his coworkers and reflects a delicate free-energy minimization that is common to all blockcopolymer materials.
Journal Article
Polymer vesicles : Materials science: Soft surfaces
Dennis E. Discher,Adi Eisenberg +1 more
TL;DR: Future applications of polymer vesicles will rely on exploiting unique property-performance relations, but results to date underscore the fact that biologically derived vesicle are but a small subset of what is physically and chemically possible.
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Biodegradation and biocompatibility of PLA and PLGA microspheres
TL;DR: This chapter is a critical review of biodegradation, biocompatibility and tissue/material interactions, and selected examples of PLA and PLGA microsphere controlled release systems, and emphasis is placed on polymer and microSphere characteristics which modulate the degradation behaviour and the foreign body reaction to the microspheres.
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Polymersomes: tough vesicles made from diblock copolymers.
Bohdana M. Discher,You-Yeon Won,David S. Ege,James C. Lee,Frank S. Bates,Dennis E. Discher,Daniel A. Hammer +6 more
TL;DR: The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry, and both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements.