Journal ArticleDOI
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.
Fariyal Ahmed,Dennis E. Discher +1 more
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TLDR
With all compositions, in both 100 nm and giant vesicles, the average release time reflects a highly quantized process in which any given vesicle is either intact and retains its encapsulant, or is porated and slowly disintegrates.About:
This article is published in Journal of Controlled Release.The article was published on 2004-04-16. It has received 638 citations till now. The article focuses on the topics: Controlled release & Polymersome.read more
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Polymer-based nanocapsules for drug delivery
TL;DR: A comparative analysis is given of the size, zeta-potential, dispersion pH, shell thickness, encapsulation efficiency, active substance release, stability and in vivo and in vitro pharmacological performances, which allows establishing criteria for selecting a method for preparation of nanocapsules according to its advantages, limitations and behaviours as a drug carrier.
Journal ArticleDOI
Self-Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications.
TL;DR: This review is focused on the inherent advantages in using polymer vesicles over their small molecule lipid counterparts and the potential applications in biology for both drug delivery and synthetic cellular reactors.
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Stimuli-responsive polymersomes for programmed drug delivery.
TL;DR: In this article, recent advances in stimuli-sensitive polymersomes have been reviewed, and perspectives on future developments have been discussed.
Journal ArticleDOI
A review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: micelles, nanospheres, nanocapsules and polymersomes.
Kevin Letchford,Helen M. Burt +1 more
TL;DR: This review attempts to clarify some of the terminology used in the literature by providing an overview of the major features of each type of nanoparticle and the factors that influence the formation of particular nanoparticulate formulations.
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Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications ☆
TL;DR: This review gives a brief overview about some types of stimuli-responsive nanocarriers with the main focus on organic polymer-based systems.
References
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Journal ArticleDOI
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
TL;DR: The PEG‐PE's activity to prolong the circulation time of liposomes is greater than that of the ganglioside GM1, awell‐described glycolipid with this activity.
Journal ArticleDOI
Polymer-polymer phase behavior.
TL;DR: Two representative molecular architectures, binary linear homopolymer mixtures and diblock copolymers, exhibiting macrophase separation and microphase segregation, respectively, are examined in some detail.
Journal ArticleDOI
On the Origins of Morphological Complexity in Block Copolymer Surfactants
Sumeet Jain,Frank S. Bates +1 more
TL;DR: Experiments with poly(1,2-butadiene-b-ethylene oxide) diblock copolymers are described, which form Y-junctions and three-dimensional networks in water at weight fractions of PEO intermediate to those associated with vesicle and wormlike micelle morphologies.
Journal ArticleDOI
Micellar nanocontainers distribute to defined cytoplasmic organelles.
TL;DR: Block copolymer micelles are water-soluble biocompatible nanocontainers with great potential for delivering hydrophobic drugs but localization in several cytoplasmic organelles, including mitochondria, but not in the nucleus is revealed.
Book
Biodegradable polymers as drug delivery systems
Mark Chasin,Robert Langer +1 more
TL;DR: In this article, the properties, synthesis, and formulations of a number of well studied polymers increasingly being used in site-specific or systematic administration of pharmaceutical agents are reviewed and discussed.