Journal ArticleDOI
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.
Fariyal Ahmed,Dennis E. Discher +1 more
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TLDR
With all compositions, in both 100 nm and giant vesicles, the average release time reflects a highly quantized process in which any given vesicle is either intact and retains its encapsulant, or is porated and slowly disintegrates.About:
This article is published in Journal of Controlled Release.The article was published on 2004-04-16. It has received 638 citations till now. The article focuses on the topics: Controlled release & Polymersome.read more
Citations
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Journal ArticleDOI
Stabilization of Polymersome Vesicles by an Interpenetrating Polymer Network
Feng Li,Tijs Ketelaar,Antonius T. M. Marcelis,Frans A. M. Leermakers,Martien A. Cohen Stuart,Ernst J. R. Sudhölter +5 more
TL;DR: In this article, vesicles from Pluronic L121 were stabilized by an interpenetrating polymer network from pentaerythritol tetraacrylate by UV or thermal initiator induced radical polymerization.
Book ChapterDOI
Comparison of Simulations of Lipid Membranes with Membranes of Block Copolymers
Kostas Ch. Daoulas,Marcus Müller +1 more
TL;DR: An overview of molecular models and computer simulation techniques for amphiphilic vesicles formed either by lipid or block copolymer molecules is presented in this paper, where the authors describe the underlying atomistic structure through a few relevant interactions, whose strength is characterized by coarse-grained parameters.
Journal ArticleDOI
Repurposing of Guanabenz Acetate by Encapsulation into Long-Circulating Nanopolymersomes for Treatment of Triple-Negative Breast Cancer
Yusuf A. Haggag,Mohamed Yasser,Murtaza M. Tambuwala,Suleiman S. El Tokhy,Mohammad Isreb,Ahmed A. Donia +5 more
TL;DR: In this paper, Guanabenz acetate (GA) is used to formulate a polymersome-based cancer nanomedicine to treat triple-negative breast cancer (TNBC).
Journal ArticleDOI
Mastering the Tools: Natural versus Artificial Vesicles in Nanomedicine.
Loredana Leggio,Giuseppe Arrabito,Vittorio Ferrara,Silvia Vivarelli,Greta Paternò,Bianca Marchetti,Bruno Pignataro,Nunzio Iraci +7 more
TL;DR: Current manufacturing techniques used to produce both natural and artificial vesicles are summarized, exploring the promises and pitfalls of the different production processes and the current applications of both kinds of vesicle in the healthcare field.
Journal ArticleDOI
Advances on the formulation of proteins using nanotechnologies
TL;DR: An overview of the mostly explored nanotechnologies to date intended to produce lipidic and polymeric nanocarriers for protein/peptide delivery, highlighting the nanomedicines that have reached the market or the clinical development phase is provided.
References
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Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
Journal ArticleDOI
Block Copolymers—Designer Soft Materials
TL;DR: The Knitting Pattern as mentioned in this paper is a block copolymer that was discovered by Reimund Stadler and his coworkers and reflects a delicate free-energy minimization that is common to all blockcopolymer materials.
Journal Article
Polymer vesicles : Materials science: Soft surfaces
Dennis E. Discher,Adi Eisenberg +1 more
TL;DR: Future applications of polymer vesicles will rely on exploiting unique property-performance relations, but results to date underscore the fact that biologically derived vesicle are but a small subset of what is physically and chemically possible.
Journal ArticleDOI
Biodegradation and biocompatibility of PLA and PLGA microspheres
TL;DR: This chapter is a critical review of biodegradation, biocompatibility and tissue/material interactions, and selected examples of PLA and PLGA microsphere controlled release systems, and emphasis is placed on polymer and microSphere characteristics which modulate the degradation behaviour and the foreign body reaction to the microspheres.
Journal ArticleDOI
Polymersomes: tough vesicles made from diblock copolymers.
Bohdana M. Discher,You-Yeon Won,David S. Ege,James C. Lee,Frank S. Bates,Dennis E. Discher,Daniel A. Hammer +6 more
TL;DR: The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry, and both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements.