Journal ArticleDOI
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.
Fariyal Ahmed,Dennis E. Discher +1 more
Reads0
Chats0
TLDR
With all compositions, in both 100 nm and giant vesicles, the average release time reflects a highly quantized process in which any given vesicle is either intact and retains its encapsulant, or is porated and slowly disintegrates.About:
This article is published in Journal of Controlled Release.The article was published on 2004-04-16. It has received 638 citations till now. The article focuses on the topics: Controlled release & Polymersome.read more
Citations
More filters
Journal ArticleDOI
Dissipative particle dynamics simulations of polymersomes.
Vanessa Ortiz,Steven O. Nielsen,Dennis E. Discher,Michael L. Klein,Reinhard Lipowsky,Julian C. Shillcock +5 more
TL;DR: A DPD model of PEO-based block copolymer vesicles in water is developed by introducing a new density based coarse graining and by using experimental data for interfacial tension.
Journal ArticleDOI
Drug Carrier for Photodynamic Cancer Therapy
TL;DR: Several organic and inorganic PS carriers that have been studied to enhance the efficacy of photodynamic therapy against cancer are summarized.
Journal ArticleDOI
pH-sensitive degradable chimaeric polymersomes for the intracellular release of doxorubicin hydrochloride
TL;DR: PH-sensitive degradable chimaeric polymersomes developed based on asymmetric poly(ethylene glycol)-b-poly(2,4,6-trimethoxybenzylidene-1, 1,1,1-tris(hydroxymethyl)ethane methacrylate)-b(acrylic acid) triblock copolymers for active loading as well as triggered intracellular release of hydrophilic doxorubic
Journal ArticleDOI
Polymer Vesicles Containing Small Vesicles within Interior Aqueous Compartments and pH‐Responsive Transmembrane Channels
TL;DR: The first example of polymeric multivesicle assemblies similar to the architectural arrangement of eukaryotic cells is shown, in which both the vesicle membranes are equipped with pH-responsive channels permeable for hydrophilic solutes.
Journal ArticleDOI
Active loading and tunable release of doxorubicin from block copolymer vesicles.
TL;DR: Tuning the wall permeability allows loading and release of molecules from vesicles to be controlled and can enhance the loading level up to 10-fold relative to loading in the absence of the gradient.
References
More filters
Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
Journal ArticleDOI
Block Copolymers—Designer Soft Materials
TL;DR: The Knitting Pattern as mentioned in this paper is a block copolymer that was discovered by Reimund Stadler and his coworkers and reflects a delicate free-energy minimization that is common to all blockcopolymer materials.
Journal Article
Polymer vesicles : Materials science: Soft surfaces
Dennis E. Discher,Adi Eisenberg +1 more
TL;DR: Future applications of polymer vesicles will rely on exploiting unique property-performance relations, but results to date underscore the fact that biologically derived vesicle are but a small subset of what is physically and chemically possible.
Journal ArticleDOI
Biodegradation and biocompatibility of PLA and PLGA microspheres
TL;DR: This chapter is a critical review of biodegradation, biocompatibility and tissue/material interactions, and selected examples of PLA and PLGA microsphere controlled release systems, and emphasis is placed on polymer and microSphere characteristics which modulate the degradation behaviour and the foreign body reaction to the microspheres.
Journal ArticleDOI
Polymersomes: tough vesicles made from diblock copolymers.
Bohdana M. Discher,You-Yeon Won,David S. Ege,James C. Lee,Frank S. Bates,Dennis E. Discher,Daniel A. Hammer +6 more
TL;DR: The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry, and both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements.