Sex-specific hippocampal 5-hydroxymethylcytosine is disrupted in response to acute stress.
Ligia A. Papale,Sisi Li,Andy Madrid,Qi Zhang,Li Chen,Pankaj Chopra,Peng Jin,Sunduz Keles,Reid S. Alisch +8 more
TLDR
Together, the alterations in 5hmC presented here provide a possible molecular mechanism for the adaptive sex-specific response to stress that may augment the design of novel therapeutic agents that will have optimal effectiveness in each sex.About:
This article is published in Neurobiology of Disease.The article was published on 2016-12-01 and is currently open access. It has received 23 citations till now. The article focuses on the topics: Hippocampal formation.read more
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Sex differences: Transcriptional signatures of stress exposure in male and female brains.
TL;DR: An overview of transcriptional studies designed to understand how sex influences stress‐specific transcriptomic changes in rodent models, as well as human psychiatric patients, highlighting the use of different methodological techniques is given.
Journal ArticleDOI
Differentially Methylated Genes in Saliva are linked to Childhood Stress
TL;DR: A possible neuromolecular mechanism linking children’s social experiences with risk for anxiety and depressive disorders is indicated, suggesting that DNA methylation may regulate gene expression by mediating transcription factor binding on these genes.
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Discovery and replication of a peripheral tissue DNA methylation biosignature to augment a suicide prediction model
Makena Clive,Marco P. Boks,Christiaan H. Vinkers,Lauren M. Osborne,Jennifer L. Payne,Kerry J. Ressler,Alicia K. Smith,Holly C. Wilcox,Zachary Kaminsky +8 more
TL;DR: A DNA methylation biosignature is derived that interacts with SKA2 methylation to improve the prediction of suicidal ideation in the existing suicide prediction model across both blood and saliva data sets and may represent a biological state of immune and HPA axis modulation that mediates suicidal behavior.
Journal ArticleDOI
DNA Methylation signatures in panic disorder
Stella Iurato,Tania Carrillo-Roa,Janine Arloth,Darina Czamara,Laura Diener-Hölzl,Jennifer Lange,Bertram Müller-Myhsok,Elisabeth B. Binder,Angelika Erhardt +8 more
TL;DR: The results point to possible sex-specific methylation changes in the HECA gene for PD but overall highlight that this disorder is not associated with extensive changes in DNA methylation in peripheral blood.
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Epigenetics and meditation.
Perla Kaliman,Perla Kaliman +1 more
TL;DR: Future research questions and perspectives at the crossroads of contemplative sciences and epigenetics are analyzed in order to assess the clinical implications of these molecular outcomes and their potential long-lasting epigenetic bases.
References
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TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
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Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
Patrick O. McGowan,Aya Sasaki,Aya Sasaki,Ana C. D'Alessio,Sergiy Dymov,Benoit Labonté,Moshe Szyf,Gustavo Turecki,Michael J. Meaney,Michael J. Meaney +9 more
TL;DR: Findings translate previous results from rat to humans and suggest a common effect of parental care on the epigenetic regulation of hippocampal glucocorticoid receptor expression.
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