Journal ArticleDOI
Shigella infection and host cell death: a double-edged sword for the host and pathogen survival.
TLDR
In this article, insights are reviewed into the mechanisms underlying circumvention of the host cell death by Shigella, as an example of bacterial fine-tuning of host cellDeath pathways.About:
This article is published in Current Opinion in Microbiology.The article was published on 2021-02-01. It has received 18 citations till now. The article focuses on the topics: Pyroptosis & Necroptosis.read more
Citations
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Journal ArticleDOI
Cytosolic replication in epithelial cells fuels intestinal expansion and chronic fecal shedding of Salmonella Typhimurium.
Audrey Chong,Kendal G. Cooper,Laszlo Kari,Olof R. Nilsson,C. Hillman,Brittany A. Fleming,Qinlu Wang,Vinod Nair,Olivia Steele-Mortimer +8 more
TL;DR: In this article, the authors proposed a model whereby repeated rounds of invasion, cytosolic replication, and release of invasive STm from extruded IECs fuels the high luminal density required for fecal shedding.
Journal ArticleDOI
Pyroptosis in host defence against bacterial infection.
Dominik Brokatzky,Serge Mostowy +1 more
TL;DR: It is proposed that in-depth knowledge of pyroptosis obtained from complementary infection models can better inform future studies using higher vertebrates, including humans, and help develop innovative host-directed therapies to combat bacterial infection.
Journal ArticleDOI
The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management
Ali Nabavi-Rad,Amin Sadeghi,Hamid Asadzadeh Aghdaei,Abbas Yadegar,Sinead M. Smith,Mohammad Reza Zali +5 more
TL;DR: The gut microbiota alteration by probiotic co-supplementation in H. pylori management is discussed to predict the comprehensive effectiveness of probiotic oral administration.
Journal ArticleDOI
Cinnamaldehyde Promotes the Intestinal Barrier Functions and Reshapes Gut Microbiome in Early Weaned Rats.
TL;DR: In this article, the effects of cinnamaldehyde on gut barrier integrity, inflammatory responses, and intestinal microbiome of early weaned rats were explored, and it was shown that cinnamide supplementation significantly upregulated the expression of Muc2, TFF3 and tight junction proteins (ZO-1, claudin-1 and occludin).
Journal ArticleDOI
Gasdermin D and Beyond – Gasdermin-mediated Pyroptosis in Bacterial Infections
TL;DR: A review of recent advances in the field of gasdermin-mediated pyroptosis with a focus on bacterial infection and sepsis models in the context of humans and other animal species can be found in this article .
References
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Journal ArticleDOI
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
Journal ArticleDOI
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon,Kathryn M. Lemberg,Michael R. Lamprecht,Rachid Skouta,Eleina M. Zaitsev,Caroline E Gleason,Darpan N Patel,Andras J. Bauer,Alexandra M. Cantley,Wan Seok Yang,Barclay Morrison,Brent R. Stockwell,Brent R. Stockwell +12 more
TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.
Journal ArticleDOI
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Jianjin Shi,Yue Zhao,Kun Wang,Xuyan Shi,Wang Yue,Huanwei Huang,Yinghua Zhuang,Tao Cai,Fengchao Wang,Feng Shao +9 more
TL;DR: Gasdermin D (Gsdmd) is identified by genome-wide clustered regularly interspaced palindromic repeat-Cas9 nuclease screens of caspase-11- and caspasing-1-mediated pyroptosis in mouse bone marrow macrophages to offer insight into inflammasome-mediated immunity/diseases and change the understanding of pyroPTosis and programmed necrosis.
Journal ArticleDOI
Novel cell death program leads to neutrophil extracellular traps
Tobias A. Fuchs,Ulrike Abu Abed,Christian Goosmann,Robert Hurwitz,Ilka Schulze,Volker Wahn,Yvette Weinrauch,Volker Brinkmann,Arturo Zychlinsky +8 more
TL;DR: This novel ROS-dependent death allows neutrophils to fulfill their antimicrobial function, even beyond their lifespan.
Journal ArticleDOI
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
Alexei Degterev,Zhihong Huang,Michael Boyce,Yaqiao Li,Prakash Jagtap,Noboru Mizushima,Gregory D. Cuny,Timothy J. Mitchison,Michael A. Moskowitz,Junying Yuan +9 more
TL;DR: It is demonstrated that necroptosis contributes to delayed mouse ischemic brain injury in vivo through a mechanism distinct from that of apoptosis and offers a new therapeutic target for stroke with an extended window for neuroprotection.
Related Papers (5)
Competitive Cell Death Interactions in Pulmonary Infection: Host Modulation Versus Pathogen Manipulation.
Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion
Gunnar N. Schroeder,Hubert Hilbi +1 more