Short-term effect of dopaminergic medication on speech in early-stage Parkinson’s disease
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TLDR
The effect of dopaminergic medication on speech has rarely been examined in early stage Parkinson's disease (PD) and the respective literature is inconclusive and limited by inappropriate design with lack of PD control group as mentioned in this paper .Abstract:
The effect of dopaminergic medication on speech has rarely been examined in early-stage Parkinson's disease (PD) and the respective literature is inconclusive and limited by inappropriate design with lack of PD control group. The study aims to examine the short-term effect of dopaminergic medication on speech in PD using patients with good motor responsiveness to levodopa challenge compared to a control group of PD patients with poor motor responsiveness. A total of 60 early-stage PD patients were investigated before (OFF) and after (ON) acute levodopa challenge and compared to 30 age-matched healthy controls. PD patients were categorised into two clinical subgroups (PD responders vs. PD nonresponders) according to the comparison of their motor performance based on movement disorder society-unified Parkinson's disease rating scale, part III. Seven distinctive parameters of hypokinetic dysarthria were examined using quantitative acoustic analysis. We observed increased monopitch (p > 0.01), aggravated monoloudness (p > 0.05) and longer duration of stop consonants (p > 0.05) in PD compared to healthy controls, confirming the presence of hypokinetic dysarthria in early PD. No speech alterations from OFF to ON state were revealed in any of the two PD groups and speech dimensions investigated including monopitch, monoloudness, imprecise consonants, harsh voice, slow sequential motion rates, articulation rate, or inappropriate silences, although a subgroup of PD responders manifested obvious improvement in motor function after levodopa intake (p > 0.001). Since the short-term usage of levodopa does not easily affect voice and speech performance in PD, speech assessment may provide a medication state-independent motor biomarker of PD. read more
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TL;DR: In this paper , a U-lossian model was used to detect anomalies in the PD-affected voice and developed an automated screening method that can discriminate between the voices of PD patients and healthy volunteers while also providing a voice quality score.
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References
More filters
Journal ArticleDOI
The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment
Ziad S. Nasreddine,Natalie A. Phillips,Valérie Bédirian,Simon Charbonneau,Victor Whitehead,Isabelle Collin,Jeffrey L. Cummings,Howard Chertkow +7 more
TL;DR: A 10‐minute cognitive screening tool (Montreal Cognitive Assessment, MoCA) to assist first‐line physicians in detection of mild cognitive impairment (MCI), a clinical state that often progresses to dementia.
Journal ArticleDOI
MDS clinical diagnostic criteria for Parkinson's disease
Ronald B. Postuma,Daniela Berg,Matthew B. Stern,Werner Poewe,C. Warren Olanow,Wolfgang H. Oertel,Jose A. Obeso,Kenneth Marek,Irene Litvan,Anthony E. Lang,Glenda M. Halliday,Christopher G. Goetz,Thomas Gasser,Bruno Dubois,Piu Chan,Bastiaan R. Bloem,Charles H. Adler,Guenther Deuschl +17 more
TL;DR: The Movement Disorder Society PD Criteria retain motor parkinsonism as the core feature of the disease, defined as bradykinesia plus rest tremor or rigidity, and two levels of certainty are delineated: clinically established PD and probable PD.
Journal ArticleDOI
A Randomized Trial of Deep-Brain Stimulation for Parkinson's Disease
Günther Deuschl,Carmen Schade-Brittinger,Paul Krack,Jens Volkmann,Helmut Schäfer,Kai Bötzel,C. Daniels,Angela Deutschländer,Ulrich Dillmann,Wilhelm Eisner,Doreen Gruber,Wolfgang Hamel,Jan Herzog,Rüdiger Hilker,Stephan Klebe,Manja Kloss,J. Koy,Martin Krause,Andreas Kupsch,Delia Lorenz,Stefan Lorenzl,H. Maximilian Mehdorn,Jean Richard Moringlane,Wolfgang H. Oertel,Marcus O. Pinsker,Heinz Reichmann,Alexander Reuss,Gerd-Helge Schneider,Alfons Schnitzler,Ulrich Steude,Volker Sturm,Lars Timmermann,Volker M. Tronnier,Thomas Trottenberg,Lars Wojtecki,Elisabeth Wolf,Werner Poewe,Jürgen Voges +37 more
TL;DR: In this six-month study of patients under 75 years of age with severe motor complications of Parkinson's disease, neurostimulation of the subthalamic nucleus was more effective than medical management alone.
Journal ArticleDOI
Differential Diagnostic Patterns of Dysarthria
TL;DR: Thirty-second speech samples were studied of at least 30 patients in each of 7 discrete neurologic groups, each patient unequivocally diagnosed as being a representative of his diagnostic group, leading to results leading to these conclusions.
Journal ArticleDOI
Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing plan.
Christopher G. Goetz,Stanley Fahn,Pablo Martinez-Martin,Werner Poewe,Cristina Sampaio,Glenn T. Stebbins,Matthew B. Stern,Barbara C. Tilley,Richard Dodel,Bruno Dubois,Robert G. Holloway,Joseph Jankovic,Jaime Kulisevsky,Anthony E. Lang,Andrew J. Lees,Sue Leurgans,Peter A. LeWitt,David L. Nyenhuis,C. Warren Olanow,Olivier Rascol,Anette Schrag,Jeanne A. Teresi,Jacobus J. van Hilten,Nancy R. LaPelle +23 more
TL;DR: The MDS‐UPDRS retains the UPDRS structure of four parts with a total summed score, but the parts have been modified to provide a section that integrates nonmotor elements of PD: I, Nonmotor Experiences of Daily Living; II, Motor Exper experiences of daily Living; III, Motor Examination; and IV, Motor Complications.