Journal ArticleDOI
Signal sequences: The limits of variation
TLDR
The results show subtle differences between eukaryotic and prokaryotic sequences, but the general impression of signal sequences as being highly variable is reinforced.About:
This article is published in Journal of Molecular Biology.The article was published on 1985-07-05. It has received 2053 citations till now. The article focuses on the topics: Signal.read more
Citations
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Journal ArticleDOI
A new method for predicting signal sequence cleavage sites.
TL;DR: A new method for identifying secretory signal sequences and for predicting the site of cleavage between a signal sequence and the mature exported protein is described.
Journal ArticleDOI
Predicting subcellular localization of proteins based on their N-terminal amino acid sequence.
TL;DR: A neural network-based tool, TargetP, for large-scale subcellular location prediction of newly identified proteins has been developed and it is estimated that 10% of all plant proteins are mitochondrial and 14% chloroplastic, and that the abundance of secretory proteins, in both Arabidopsis and Homo, is around 10%.
Journal ArticleDOI
A Receptor Kinase-Like Protein Encoded by the Rice Disease Resistance Gene, Xa21
Wen-Yuan Song,Guo-Liang Wang,Lili Chen,Han Suk Kim,Liya Pi,Tom Holsten,John M. Gardner,Bei Wang,Wen Xue Zhai,Li Huang Zhu,Claude M. Fauquet,Pamela C. Ronald +11 more
TL;DR: The rice Xa21 gene, which confers resistance to Xanthomonas oryzae pv. race 6, was isolated by positional cloning and the sequence of the predicted protein, which carries both a leucine-rich repeat motif and a serine-threonine kinase-like domain, suggests a role in cell surface recognition of a pathogen ligand and subsequent activation of an intracellular defense response.
A receptor kinase-like protein encoded by the rice disease resistance gene, Xa21. - eScholarship
W Y Song,G L Wang,L L Chen,H S Kim,L Y Pi,T Holsten,J Gardner,B Wang,W X Zhai,L H Zhu,C Fauquet,P Ronald +11 more
TL;DR: The sequence of the predicted protein, which carries both a leucine-rich repeat motif and a serine-threonine kinase-like domain, suggests a role in cell surface recognition of a pathogen ligand and subsequent activation of an intracellular defense response.
Journal ArticleDOI
Identification and characterization of the tuberous sclerosis gene on chromosome 16
Mark Nellist,Bart Janssen,Phillip T. Brook-Carter,Arjenne L. W. Hesseling-Janssen,Magitha M. Maheshwar,Senno Verhoef,Ans M.W. van den Ouweland,Dick Lindhout,Bert Eussen,Isabel Cordeiro,Heloisa Santos,Dicky J. J. Halley,Julian R. Sampson,Christopher J. Ward,Belén Peral,Sandra Thomas,Jim R. Hughes,Peter C. Harris,Jeroen H. Roelfsema,Jasper J. Saris,Lia Spruit,Dorien J.M. Peters,J. G. Dauwerse,Martijn H. Bruening +23 more
TL;DR: Northern blot analysis identified a shortened transcript, while reduced expression was observed in another TSC family, confirming TSC2 as the chromosome 16 TSC gene, and its protein product, tuberin, has a region of homology to the GTPase-activating protein GAP3.
References
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Journal ArticleDOI
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
Axel Ullrich,Lisa M. Coussens,Joel S. Hayflick,Thomas J. Dull,Alane M. Gray,A W Tam,Jeffrey E. Lee,Yosef Yarden,Towia A. Libermann,Joseph Schlessinger +9 more
TL;DR: The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted ν-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains.
Journal ArticleDOI
Patterns of Amino Acids near Signal‐Sequence Cleavage Sites
TL;DR: In this paper, some such patterns, based on a sample of 78 eukaryotic signal sequences, are presented and discussed, and a first attempt at formulating rules for the prediction of cleavage sites is made.
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A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides
TL;DR: The proposed existence of a signal peptidase recognition sequence A-X-B with the preferred cleavage site located after the sixth amino acid following the core sequence is proposed.
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The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesis
TL;DR: It is proposed that the initial event in the secretion of proteins across membranes and their insertion into membranes is the spontaneous penetration of the hydrophobic portion of the bilayer by a helical hairpin.
Journal ArticleDOI
How signal sequences maintain cleavage specificity.
TL;DR: Further patterns of non-random amino acid utilization in a region around in vivo cleavage sites are presented, and they can be interpreted in terms of selection acting to reduce the number of potential competing sites in the vicinity of the correct one.