Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials.
Merryn Voysey,S A Costa Clemens,Shabir A. Madhi,Lily Yin Weckx,P M Folegatti,Parvinder K. Aley,Brian Angus,Vicky L. Baillie,Vicky L. Baillie,Shaun Barnabas,Q E Bhorat,S Bibi,Carmen Briner,P Cicconi,Elizabeth A. Clutterbuck,Andrea M. Collins,Clare L. Cutland,Clare L. Cutland,Thomas C. Darton,Keertan Dheda,Christina Dold,Duncan Cja.,Emary Krw.,Katie J. Ewer,Amy Flaxman,Lee Fairlie,Saul N. Faust,Shuo Feng,Daniela M. Ferreira,Adam Finn,Eva P. Galiza,Anna Goodman,Catherine M. Green,Christopher A Green,Melanie Greenland,Christopher Hill,Christopher Hill,Helen Hill,Ian Hirsch,Alane Izu,Alane Izu,D Jenkin,Joe Ccd.,Simon Kerridge,Anthonet Koen,Anthonet Koen,Gaurav Kwatra,Gaurav Kwatra,Rajeka Lazarus,Vincenzo Libri,Patrick J. Lillie,N G Marchevsky,R P Marshall,Mendes Ava.,Eveline Pipolo Milan,Angela M. Minassian,Alastair McGregor,Yama F Mujadidi,Amit J Nana,S D Padayachee,Daniel J. Phillips,A Pittella,Emma Plested,Katrina M Pollock,M N Ramasamy,Adam J. Ritchie,Hannah Robinson,Alexandre Vargas Schwarzbold,Andrew Smith,R Song,Matthew D. Snape,Eduardo Sprinz,Rebecca K. Sutherland,E. Thomson,M E Török,Mark Toshner,Turner Dpj.,Johan Vekemans,Tonya Villafana,Thomas E. White,C J Williams,Alexander D. Douglas,Hill Avs.,Teresa Lambe,Sarah C. Gilbert,Andrew J. Pollard,M Aban,Abeyskera Kwm.,J Aboagye,M Adam,Kirsty Adams,J P Adamson,G Adewatan,Syed Adlou,Katie A. Ahmed,Y Akhalwaya,S Akhalwaya,A Alcock,A Ali,Elizabeth R. Allen,Lauren Allen,F B Alvernaz,F S Amorim,C S Andrade,F Andritsou,Rachel Anslow,E H Arbe-Barnes,Mark P. Ariaans,B Arns,L Arruda,L Assad,Azi Pda.,Azi Lda.,G Babbage,C Bailey,K F Baker,Megan Baker,Natalie Baker,Philip Baker,I Baleanu,D Bandeira,A Bara,Barbosa Mas.,D Barker,Gavin Barlow,Eleanor Barnes,A S Barr,Jordan R. Barrett,Jeffrey C. Barrett,K Barrett,L Bates,A Batten,Kirsten Beadon,E Beales,R Beckley,Sandra Belij-Rammerstorfer,Jennifer L Bell,D Bellamy,S Belton,Adam Berg,L Bermejo,Eleanor Berrie,Louise Berry,D Berzenyi,Amy Beveridge,Kevin R. Bewley,I Bharaj,Sutika Bhikha,As’ad E. Bhorat,Z E Bhorat,E M Bijker,Sarah Birch,G Birch,K Birchall,A Bird,O Bird,Karen Bisnauthsing,M Bittaye,L Blackwell,R Blacow,H Bletchly,C L Blundell,Blundell,P Bodalia,E Bolam,E Boland,D Bormans,N Borthwick,F Bowring,Amy Boyd,P Bradley,T Brenner,Alice Bridges-Webb,Phillip Brown,Colin S Brown,C Brown-O’Sullivan,S Bruce,Emily Brunt,W Budd,Y A Bulbulia,Matthew J. Bull,J Burbage,A Burn,Karen R. Buttigieg,N Byard,I Cabrera Puig,Anna M. Calvert,S Camara,M Cao,Federica Cappuccini,R Cardona,Cardoso,M Carr,Miles W. Carroll,Andrew Carson-Stevens,Carvalho Ydm.,H R Casey,P Cashen,Castro Try.,L C Castro,Katrina Cathie,A Cavey,J Cerbino-Neto,Cezar Lff.,J Chadwick,C Chanice,Daniel Chapman,Sue Charlton,K S Cheliotis,Irina Chelysheva,O Chester,E Chiplin,S Chita,Cho J-S.,Lucía Cifuentes,E Clark,M Clark,R Colin-Jones,Collins Slk.,Hayley Colton,Christopher P. Conlon,S Connarty,Naomi Coombes,Cyrus Cooper,R Cooper,L Cornelissen,T Corrah,Catherine Cosgrove,F B Costa,T Cox,Crocker Wem.,S Crosbie,D Cullen,Cunha Drmf.,C J Cunningham,F C Cuthbertson,D M da Costa,Da Guarda Snf.,L P da Silva,A C da Silva Moraes,B E Damratoski,Z Danos,Dantas Mtdc.,M Datoo,C Datta,M Davids,Shân Davies,Kelly Davies,Heather Davies,Steve Davies,Jane C. Davies,E J Davis,J Davis,de Carvalho Jam.,J. P. de Jager,S de Jesus Jnr,L M De Oliveira Kalid,D Dearlove,Tesfaye Demissie,Amisha Desai,S Di Marco,C Di Maso,Tanya Dinesh,C Docksey,Tao Dong,Francesca R. Donnellan,T G Dos Santos,E P Dos Santos,N Douglas,C Downing,J Drake,R Drake-Brockman,Ruth E Drury,J. M. E. Du Plessis,Susanna Dunachie,A Duncan,Easom Njw.,Michelle Edwards,Nick J. Edwards,F Edwards,O M El Muhanna,Sean C. Elias,B Ellison-Handley,M J Elmore,M R English,Aliasgar Esmail,Y M Essack,M Farooq,Sofiya Fedosyuk,Sally Felle,S Ferguson,C Ferreira Da Silva,S Field,R Fisher,J Fletcher,H Fofie,H Fok,K J Ford,R Fothergill,J Fowler,Fraiman Pha.,E Francis,M M Franco,John Frater,Freire Msm.,S H Fry,S Fudge,R Furlan Filho,J Furze,Michelle Fuskova,P Galian-Rubio,H Garlant,M Gavrila,K A Gibbons,Ciaran Gilbride,Harmeet Gill,Kerry Godwin,Karishma Gokani,Gonçalves Mlf.,Gonzalez Igs.,J Goodall,J Goodwin,A Goondiwala,K Gordon-Quayle,G Gorini,A Goyanna,J Grab,L Gracie,J Green,N Greenwood,J Greffrath,M M Groenewald,A Gunawardene,Gaurav Gupta,M Hackett,Bassam Hallis,M Hamaluba,E Hamilton,J Hamlyn,D Hammersley,A T Hanrath,B Hanumunthadu,S A Harris,C Harris,T D Harrison,D Harrison,T A Harris-Wright,T C Hart,B Hartnell,J Haughney,S Hawkins,Hayano Lym.,I Head,Paul T. Heath,J A Henry,M Hermosin Herrera,David Hettle,C Higa,Jennifer Hill,G Hodges,Susanne H Hodgson,E Horne,M M Hou,C F Houlihan,E Howe,N Howell,J Humphreys,Holly E. Humphries,K Hurley,C Huson,Catherine Hyams,A Hyder-Wright,S Ikram,Alka Ishwarbhai,P Iveson,V Iyer,F Jackson,S Jackson,S Jaumdally,H Jeffers,Natasha Jesudason,C. Jones,K Jones,E Y Jones,M R Jorge,A Joshi,Júnior Eams.,Reshma Kailath,F Kana,A Kar,K Karampatsas,Mwila Kasanyinga,L Kay,J Keen,J Kellett Wright,Elizabeth J. Kelly,Deirdre Kelly,D M Kelly,Sarah Kelly,D Kerr,L Khan,B Khozoee,A Khurana,Stephen P. Kidd,A Killen,J Kinch,P Kinch,King Ldw.,T B King,L Kingham,Paul Klenerman,D M Kluczna,F Knapper,Julian C. Knight,D Knott,S Koleva,P M Lages,M Lang,G Lang,C W Larkworthy,Larwood Jpj.,R Law,Alison M. Lawrie,E M Lazarus,Amanda J. Leach,E A Lees,A Lelliott,Lemm N-M.,Lessa Aer.,S Leung,Y Li,A M Lias,K Liatsikos,A Linder,S Lipworth,S Liu,X Liu,A Lloyd,S Lloyd,L Loew,R Lopez Ramon,L B Lora,K G Luz,J C MacDonald,G MacGregor,M Madhavan,David O. Mainwaring,E Makambwa,R Makinson,M Malahleha,R Malamatsho,G Mallett,N Manning,K Mansatta,T Maoko,S Marinou,E Marlow,G N Marques,P Marriott,J L Marshall,Masebole Masenya,Mduduzi Masilela,S K Masters,M Mathew,H Matlebjane,K Matshidiso,O Mazur,A Mazzella,H McCaughan,J McEwan,J McGlashan,L McInroy,N McRobert,S McSwiggan,C Megson,S Mehdipour,W Meijs,Mendonça Rnõ.,Alexander J. Mentzer,Mesquita Acf.,P Miralhes,N Mirtorabi,Celia Mitton,S Mnyakeni,F Moghaddas,K Molapo,M Moloi,Maria Moore,M Moran,E Morey,R Morgans,Susan J. Morris,S J Morris,Hazel Morrison,F Morselli,G Morshead,R Morter,L Mottay,A Moultrie,N Moyo,M Mpelembue,S Msomi,Y Mugodi,E Mukhopadhyay,J Muller,Alasdair Munro,Sinéad M. Murphy,P Mweu,C Myerscough,G Naik,Kush Naker,Eleni Nastouli,B Ndlovu,E Nikolaou,C Njenga,H C Noal,Amy R. Noe,G Novaes,Fay L. Nugent,Nunes Gla.,Katherine L. O'Brien,Daniel H. O'Connor,Oelofse S,Blanche Oguti,V Olchawski,Neil J. Oldfield,M G Oliveira,C Oliveira,Oliveira Isq.,A Oommen-Jose,A Oosthuizen,P J O’Reilly,P J O'Reilly,P Osborne,Owen Drj.,L Owen,Daniel R Owens,N Owino,M Pacurar,Paiva Bvb.,Palhares Emf.,S Palmer,Parracho Hmrt.,K Parsons,Darshana Patel,Brij Patel,F Patel,M Patrick-Smith,Ruth O. Payne,Y Peng,E J Penn,A Pennington,M P Peralta Alvarez,B P Pereira Stuchi,A L Perez,T Perinpanathan,J Perring,R Perumal,S Y Petkar,T Philip,J Phillips,M K Phohu,L Pickup,S Pieterse,J M Pinheiro,J Piper,D Pipini,M Plank,S Plant,S Pollard,Jennifer Pooley,A Pooran,Ian D. Poulton,Claire Powers,F B Presa,Delyth Price,V Price,M R Primeira,P C Proud,Samuel Provstgaard-Morys,S Pueschel,David Pulido,S Quaid,R Rabara,K Radia,D Rajapaska,T Rajeswaran,L Ramos,Ramos Asf.,F Ramos Lopez,Tommy Rampling,J Rand,H Ratcliffe,Thomas A. Rawlinson,D Rea,B Rees,M Resuello-Dauti,E Reyes Pabon,S Rhead,Tawassal Riaz,Marivic Ricamara,A Richards,A Richter,Neil D. Ritchie,A J Robbins,H Roberts,R E Robinson,S Roche,Christine S. Rollier,Louisa Rose,A L Ross Russell,L Rossouw,S Royal,I Rudiansyah,K Ryalls,C Sabine,Stephen Saich,J C Sale,Ahmed M. Salman,N Salvador,S Salvador,Sampaio,Adel Samson,A Sanchez-Gonzalez,H Sanders,K Sanders,E Santos,Santos Guerra Mfs.,I Satti,J E Saunders,Caroline Saunders,Sayed Aba.,I Schim van der Loeff,Annina B. Schmid,E Schofield,Gavin R. Screaton,S Seddiqi,R R Segireddy,R Senger,S Serrano,Imam Shaik,Hannah Sharpe,Katherine Sharrocks,R Shaw,A Shea,E Sheehan,A Shepherd,F Shiham,S E Silk,L Silva-Reyes,Silveira Lbtd.,Silveira Mbv.,Nishanta Singh,J Sinha,D T Skelly,David Smith,Nikki Smith,H E Smith,D J Smith,Catherine C. Smith,A S Soares,C Solórzano,G L Sorio,K Sorley,T Sosa-Rodriguez,Souza Cmcdl.,Souza Bsdf.,A R Souza,T Souza Lopez,L Sowole,Alexandra J. Spencer,L Spoors,L Stafford,I Stamford,R Stein,Lisa Stockdale,L V Stockwell,L H Strickland,Arabella Stuart,A Sturdy,N Sutton,A Szigeti,Abdessamad Tahiri-Alaoui,R Tanner,C Taoushanis,Alexander W. Tarr,R Tarrant,Kathryn Mary Taylor,U Taylor,Iona J. Taylor,J Taylor,R te Water Naude,Kate Templeton,Yrene Themistocleous,Andreas C. Themistocleous,Mark G. Thomas,Kelly M. Thomas,T M Thomas,Asha Thombrayil,John R. Thompson,Fiona M. Thompson,Amber J. Thompson,K Thompson,V Thornton-Jones,Thotusi Lhs.,Patrick J. Tighe,L A Tinoco,G F Tiongson,B Tladinyane,M Tomasicchio,Adriana Tomic,Susan Tonks,J Towner,N Tran,J A Tree,G Trillana,C Trinham,R Trivett,A Truby,B L Tsheko,P Tubb,A Turabi,Richard Turner,C Turner,Nicola Turner,B Tyagi,Marta Ulaszewska,B R Underwood,S van Eck,R Varughese,D Verbart,M K Verheul,Iason Vichos,T A Vieira,G Walker,Laura L. Walker,M E Wand,T Wardell,George M. Warimwe,Simon Warren,B Watkins,Watson Mee.,E Watson,S Webb,Andrew R. Webster,J Welch,Z Wellbelove,J H Wells,A J West,Beth White,Catherine White,Rachel White,P Williams,Rachel Williams,S Willingham,R Winslow,D Woods,M Woodyer,A T Worth,Daniel B. Wright,M Wroblewska,A Yao,Yim Ytn.,M B Zambrano,R L Zimmer,D Zizi,P Zuidewind +766 more
TLDR
The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, with a regimen of two standard doses given with an interval of 4-12 weeks as discussed by the authors.About:
This article is published in The Lancet.The article was published on 2021-03-06 and is currently open access. It has received 862 citations till now. The article focuses on the topics: Booster dose & Vaccine efficacy.read more
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Induction of humoral and cellular immune responses to COVID‐19 mRNA and vector vaccines: A prospective cohort study in Bulgarian healthcare workers
Maria Nikolova,Yana Todorova,Radoslava Emilova,Iva Trifonova,Teodora Gladnishka,Nina Petrova-Yancheva,Tatyana P Chervenyakova,Elena Dragusheva,Georgi T. Popov,Iva Christova +9 more
TL;DR: One month after completing mRNA immunization, the number of IFNγ‐producing T cells correlated significantly with the levels of RBD‐specific IgA and virus‐neutralizing activity induced after priming, and enumeration of circulating virus‐specificIFNγ+ T cells is not recommended for evaluation of protective immunity.
Journal ArticleDOI
Oxford-AstraZeneca COVID-19 vaccine: need of a reasoned and effective vaccine campaign.
A. Vallée,A. Chan-Hew-Wai,B. Bonan,P. Lesprit,François Parquin,É. Catherinot,J. Choucair,D. Billard,C. Amiel-Taieb,È. Camps,C. Cerf,D. Zucman,E. Fourn +12 more
TL;DR: In this paper, the COVID-19 vaccine campaign is needed to reach the herd immunity and reduce this pandemic infection. But the benefit/risk balance is clearly in favor of vaccination.
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Persistence of protection against SARS-CoV-2 clinical outcomes up to 9 months since vaccine completion: a retrospective observational analysis in Lombardy, Italy
TL;DR: In this paper , the effect of time since vaccine completion on the SARS-CoV-2 infection and its severe forms was investigated, and trends in vaccine effectiveness (i.e., outcomes comparison in vaccinated and unvaccinated individuals) were also measured.
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COVID-19 vaccines: Frequently asked questions and updated answers.
TL;DR: In this article, the authors proposed a report on both today's state of knowledge, and the 14 February 2021 recommendations of the French health authorities on anti-SARS-CoV-2 vaccines as regards their development, their modes of action, their effectiveness, their limits, and their utilization in different situations.
Journal ArticleDOI
A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates.
Chang Guo,Yanan Peng,Lin Lin,Xiaoyan Pan,Mengqi Fang,Yun Zhao,Keyan Bao,Runhan Li,Jian-Bao Han,Jiaorong Chen,Tian-Zhang Song,Xiao-Li Feng,Yahong Zhou,Gan Zhao,Leike Zhang,Yong-Tang Zheng,Ping Zhu,Haiying Hang,Linqi Zhang,Zhaolin Hua,Hongyu Deng,Baidong Hou +21 more
TL;DR: In this paper, a phage-derived virus-like particle carrying bacterial RNA as TLR ligands with the receptor-binding domain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S protein was used as the target antigen.
References
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
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Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.
Merryn Voysey,Clemens Sac.,Shabir A. Madhi,Lily Yin Weckx,P M Folegatti,Parvinder K. Aley,Brian Angus,Vicky L. Baillie,Shaun Barnabas,Q E Bhorat,S Bibi,Carmen Briner,P Cicconi,Andrea M. Collins,R Colin-Jones,Clare L. Cutland,Thomas C. Darton,Keertan Dheda,Duncan Cja.,Emary Krw.,Katie J. Ewer,Lee Fairlie,Saul N. Faust,Shuo Feng,Daniela M. Ferreira,Adam Finn,Anna Goodman,Catherine M. Green,Christopher A Green,Paul T. Heath,Christopher Hill,Helen Hill,Ian Hirsch,Hodgson Shc.,Allen Izu,S Jackson,D Jenkin,Joe Ccd.,S Kerridge,Anthonet Koen,Gaurav Kwatra,Rajeka Lazarus,Alison M. Lawrie,A Lelliott,Vincenzo Libri,Patrick J. Lillie,R Mallory,Mendes Ava.,Eveline Pipolo Milan,Angela M. Minassian,Alastair McGregor,Hazel Morrison,Y Mujadidi,Amit J Nana,P J O’Reilly,S D Padayachee,A Pittella,E Plested,Katrina M Pollock,M N Ramasamy,S Rhead,Alexandre Vargas Schwarzbold,Nisha Singh,Andrew Smith,R Song,Matthew D. Snape,Eduardo Sprinz,Rebecca K. Sutherland,R Tarrant,E. Thomson,M E Török,Mark Toshner,Turner Dpj.,Johan Vekemans,Tonya Villafana,Watson Mee.,C J Williams,Alexander D. Douglas,Hill Avs.,Teresa Lambe,Sarah C. Gilbert,Andrew J. Pollard +81 more
TL;DR: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials.
Journal ArticleDOI
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Lindsey R. Baden,Hana M. El Sahly,Brandon Essink,Karen L. Kotloff,Sharon E. Frey,Rick Novak,David Diemert,Stephen A. Spector,Nadine Rouphael,C. Buddy Creech,John W McGettigan,Shishir Khetan,Nathan Segall,Joel Solis,Adam Brosz,Carlos Fierro,Howard J. Schwartz,Kathleen M. Neuzil,Lawrence Corey,Peter B. Gilbert,Holly Janes,Dean Follmann,Mary A. Marovich,John R. Mascola,Laura Polakowski,Julie E. Ledgerwood,Barney S. Graham,Hamilton Bennett,Rolando Pajon,Conor Knightly,Brett Leav,Weiping Deng,Honghong Zhou,Shu Liang Han,Melanie Ivarsson,Jacqueline Miller,Tal Z Zaks +36 more
TL;DR: The mRNA-1273 vaccine as discussed by the authors is a lipid nanoparticle-encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19.
Journal ArticleDOI
Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
P M Folegatti,Katie J. Ewer,Parvinder K. Aley,Brian Angus,Stephan Becker,Sandra Belij-Rammerstorfer,D Bellamy,S Bibi,M Bittaye,Elizabeth A. Clutterbuck,Christina Dold,Saul N. Faust,Adam Finn,Amy Flaxman,Bassam Hallis,Paul T. Heath,D Jenkin,Rajeka Lazarus,R Makinson,Angela M. Minassian,Katrina M Pollock,M N Ramasamy,Hannah Robinson,Matthew D. Snape,R Tarrant,Merryn Voysey,Catherine M. Green,Alexander D. Douglas,Hill Avs.,Teresa Lambe,Sarah C. Gilbert,Andrew J. Pollard +31 more
TL;DR: A phase 1/2, single-blind, randomized controlled trial in five trial sites in the UK of a chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19) expressing the SARS-CoV2 spike protein compared with a meningococcal conjugate vaccine (MenACWY) as control was conducted.
Journal ArticleDOI
Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial.
M N Ramasamy,Angela M. Minassian,Katie J. Ewer,Amy Flaxman,P M Folegatti,Daniel R Owens,Merryn Voysey,Parvinder K. Aley,Brian Angus,G Babbage,Sandra Belij-Rammerstorfer,L Berry,S Bibi,M Bittaye,Katrina Cathie,H Chappell,Sue Charlton,P Cicconi,Elizabeth A. Clutterbuck,R Colin-Jones,Christina Dold,Emary Krw.,Sofiya Fedosyuk,Michelle Fuskova,Diane Gbesemete,Christopher A Green,Bassam Hallis,M M Hou,D Jenkin,Joe Ccd.,Elizabeth J. Kelly,S Kerridge,Alison M. Lawrie,A Lelliott,May Nwe Lwin,R Makinson,N G Marchevsky,Y Mujadidi,Munro Aps.,M Pacurar,E Plested,J Rand,Thomas A. Rawlinson,S Rhead,Hannah Robinson,Adam J. Ritchie,A L Ross-Russell,Stephen Saich,Nisha Singh,Catherine C. Smith,Matthew D. Snape,R Song,R Tarrant,Yrene Themistocleous,Kelly M. Thomas,Tonya Villafana,Sarah Warren,Watson Mee.,Alexander D. Douglas,Hill Avs.,Teresa Lambe,Sarah C. Gilbert,Saul N. Faust,Andrew J. Pollard +63 more
TL;DR: The specific objectives of this report were to assess the safety and humoral and cellular immunogenicity of a single-dose and two-dose schedule in adults older than 55 years, and safety, as measured by the occurrence of serious adverse events.
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