Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials.
Merryn Voysey,S A Costa Clemens,Shabir A. Madhi,Lily Yin Weckx,P M Folegatti,Parvinder K. Aley,Brian Angus,Vicky L. Baillie,Vicky L. Baillie,Shaun Barnabas,Q E Bhorat,S Bibi,Carmen Briner,P Cicconi,Elizabeth A. Clutterbuck,Andrea M. Collins,Clare L. Cutland,Clare L. Cutland,Thomas C. Darton,Keertan Dheda,Christina Dold,Duncan Cja.,Emary Krw.,Katie J. Ewer,Amy Flaxman,Lee Fairlie,Saul N. Faust,Shuo Feng,Daniela M. Ferreira,Adam Finn,Eva P. Galiza,Anna Goodman,Catherine M. Green,Christopher A Green,Melanie Greenland,Christopher Hill,Christopher Hill,Helen Hill,Ian Hirsch,Alane Izu,Alane Izu,D Jenkin,Joe Ccd.,Simon Kerridge,Anthonet Koen,Anthonet Koen,Gaurav Kwatra,Gaurav Kwatra,Rajeka Lazarus,Vincenzo Libri,Patrick J. Lillie,N G Marchevsky,R P Marshall,Mendes Ava.,Eveline Pipolo Milan,Angela M. Minassian,Alastair McGregor,Yama F Mujadidi,Amit J Nana,S D Padayachee,Daniel J. Phillips,A Pittella,Emma Plested,Katrina M Pollock,M N Ramasamy,Adam J. Ritchie,Hannah Robinson,Alexandre Vargas Schwarzbold,Andrew Smith,R Song,Matthew D. Snape,Eduardo Sprinz,Rebecca K. Sutherland,E. Thomson,M E Török,Mark Toshner,Turner Dpj.,Johan Vekemans,Tonya Villafana,Thomas E. White,C J Williams,Alexander D. Douglas,Hill Avs.,Teresa Lambe,Sarah C. Gilbert,Andrew J. Pollard,M Aban,Abeyskera Kwm.,J Aboagye,M Adam,Kirsty Adams,J P Adamson,G Adewatan,Syed Adlou,Katie A. Ahmed,Y Akhalwaya,S Akhalwaya,A Alcock,A Ali,Elizabeth R. Allen,Lauren Allen,F B Alvernaz,F S Amorim,C S Andrade,F Andritsou,Rachel Anslow,E H Arbe-Barnes,Mark P. Ariaans,B Arns,L Arruda,L Assad,Azi Pda.,Azi Lda.,G Babbage,C Bailey,K F Baker,Megan Baker,Natalie Baker,Philip Baker,I Baleanu,D Bandeira,A Bara,Barbosa Mas.,D Barker,Gavin Barlow,Eleanor Barnes,A S Barr,Jordan R. Barrett,Jeffrey C. Barrett,K Barrett,L Bates,A Batten,Kirsten Beadon,E Beales,R Beckley,Sandra Belij-Rammerstorfer,Jennifer L Bell,D Bellamy,S Belton,Adam Berg,L Bermejo,Eleanor Berrie,Louise Berry,D Berzenyi,Amy Beveridge,Kevin R. Bewley,I Bharaj,Sutika Bhikha,As’ad E. Bhorat,Z E Bhorat,E M Bijker,Sarah Birch,G Birch,K Birchall,A Bird,O Bird,Karen Bisnauthsing,M Bittaye,L Blackwell,R Blacow,H Bletchly,C L Blundell,Blundell,P Bodalia,E Bolam,E Boland,D Bormans,N Borthwick,F Bowring,Amy Boyd,P Bradley,T Brenner,Alice Bridges-Webb,Phillip Brown,Colin S Brown,C Brown-O’Sullivan,S Bruce,Emily Brunt,W Budd,Y A Bulbulia,Matthew J. Bull,J Burbage,A Burn,Karen R. Buttigieg,N Byard,I Cabrera Puig,Anna M. Calvert,S Camara,M Cao,Federica Cappuccini,R Cardona,Cardoso,M Carr,Miles W. Carroll,Andrew Carson-Stevens,Carvalho Ydm.,H R Casey,P Cashen,Castro Try.,L C Castro,Katrina Cathie,A Cavey,J Cerbino-Neto,Cezar Lff.,J Chadwick,C Chanice,Daniel Chapman,Sue Charlton,K S Cheliotis,Irina Chelysheva,O Chester,E Chiplin,S Chita,Cho J-S.,Lucía Cifuentes,E Clark,M Clark,R Colin-Jones,Collins Slk.,Hayley Colton,Christopher P. Conlon,S Connarty,Naomi Coombes,Cyrus Cooper,R Cooper,L Cornelissen,T Corrah,Catherine Cosgrove,F B Costa,T Cox,Crocker Wem.,S Crosbie,D Cullen,Cunha Drmf.,C J Cunningham,F C Cuthbertson,D M da Costa,Da Guarda Snf.,L P da Silva,A C da Silva Moraes,B E Damratoski,Z Danos,Dantas Mtdc.,M Datoo,C Datta,M Davids,Shân Davies,Kelly Davies,Heather Davies,Steve Davies,Jane C. Davies,E J Davis,J Davis,de Carvalho Jam.,J. P. de Jager,S de Jesus Jnr,L M De Oliveira Kalid,D Dearlove,Tesfaye Demissie,Amisha Desai,S Di Marco,C Di Maso,Tanya Dinesh,C Docksey,Tao Dong,Francesca R. Donnellan,T G Dos Santos,E P Dos Santos,N Douglas,C Downing,J Drake,R Drake-Brockman,Ruth E Drury,J. M. E. Du Plessis,Susanna Dunachie,A Duncan,Easom Njw.,Michelle Edwards,Nick J. Edwards,F Edwards,O M El Muhanna,Sean C. Elias,B Ellison-Handley,M J Elmore,M R English,Aliasgar Esmail,Y M Essack,M Farooq,Sofiya Fedosyuk,Sally Felle,S Ferguson,C Ferreira Da Silva,S Field,R Fisher,J Fletcher,H Fofie,H Fok,K J Ford,R Fothergill,J Fowler,Fraiman Pha.,E Francis,M M Franco,John Frater,Freire Msm.,S H Fry,S Fudge,R Furlan Filho,J Furze,Michelle Fuskova,P Galian-Rubio,H Garlant,M Gavrila,K A Gibbons,Ciaran Gilbride,Harmeet Gill,Kerry Godwin,Karishma Gokani,Gonçalves Mlf.,Gonzalez Igs.,J Goodall,J Goodwin,A Goondiwala,K Gordon-Quayle,G Gorini,A Goyanna,J Grab,L Gracie,J Green,N Greenwood,J Greffrath,M M Groenewald,A Gunawardene,Gaurav Gupta,M Hackett,Bassam Hallis,M Hamaluba,E Hamilton,J Hamlyn,D Hammersley,A T Hanrath,B Hanumunthadu,S A Harris,C Harris,T D Harrison,D Harrison,T A Harris-Wright,T C Hart,B Hartnell,J Haughney,S Hawkins,Hayano Lym.,I Head,Paul T. Heath,J A Henry,M Hermosin Herrera,David Hettle,C Higa,Jennifer Hill,G Hodges,Susanne H Hodgson,E Horne,M M Hou,C F Houlihan,E Howe,N Howell,J Humphreys,Holly E. Humphries,K Hurley,C Huson,Catherine Hyams,A Hyder-Wright,S Ikram,Alka Ishwarbhai,P Iveson,V Iyer,F Jackson,S Jackson,S Jaumdally,H Jeffers,Natasha Jesudason,C. Jones,K Jones,E Y Jones,M R Jorge,A Joshi,Júnior Eams.,Reshma Kailath,F Kana,A Kar,K Karampatsas,Mwila Kasanyinga,L Kay,J Keen,J Kellett Wright,Elizabeth J. Kelly,Deirdre Kelly,D M Kelly,Sarah Kelly,D Kerr,L Khan,B Khozoee,A Khurana,Stephen P. Kidd,A Killen,J Kinch,P Kinch,King Ldw.,T B King,L Kingham,Paul Klenerman,D M Kluczna,F Knapper,Julian C. Knight,D Knott,S Koleva,P M Lages,M Lang,G Lang,C W Larkworthy,Larwood Jpj.,R Law,Alison M. Lawrie,E M Lazarus,Amanda J. Leach,E A Lees,A Lelliott,Lemm N-M.,Lessa Aer.,S Leung,Y Li,A M Lias,K Liatsikos,A Linder,S Lipworth,S Liu,X Liu,A Lloyd,S Lloyd,L Loew,R Lopez Ramon,L B Lora,K G Luz,J C MacDonald,G MacGregor,M Madhavan,David O. Mainwaring,E Makambwa,R Makinson,M Malahleha,R Malamatsho,G Mallett,N Manning,K Mansatta,T Maoko,S Marinou,E Marlow,G N Marques,P Marriott,J L Marshall,Masebole Masenya,Mduduzi Masilela,S K Masters,M Mathew,H Matlebjane,K Matshidiso,O Mazur,A Mazzella,H McCaughan,J McEwan,J McGlashan,L McInroy,N McRobert,S McSwiggan,C Megson,S Mehdipour,W Meijs,Mendonça Rnõ.,Alexander J. Mentzer,Mesquita Acf.,P Miralhes,N Mirtorabi,Celia Mitton,S Mnyakeni,F Moghaddas,K Molapo,M Moloi,Maria Moore,M Moran,E Morey,R Morgans,Susan J. Morris,S J Morris,Hazel Morrison,F Morselli,G Morshead,R Morter,L Mottay,A Moultrie,N Moyo,M Mpelembue,S Msomi,Y Mugodi,E Mukhopadhyay,J Muller,Alasdair Munro,Sinéad M. Murphy,P Mweu,C Myerscough,G Naik,Kush Naker,Eleni Nastouli,B Ndlovu,E Nikolaou,C Njenga,H C Noal,Amy R. Noe,G Novaes,Fay L. Nugent,Nunes Gla.,Katherine L. O'Brien,Daniel H. O'Connor,Oelofse S,Blanche Oguti,V Olchawski,Neil J. Oldfield,M G Oliveira,C Oliveira,Oliveira Isq.,A Oommen-Jose,A Oosthuizen,P J O’Reilly,P J O'Reilly,P Osborne,Owen Drj.,L Owen,Daniel R Owens,N Owino,M Pacurar,Paiva Bvb.,Palhares Emf.,S Palmer,Parracho Hmrt.,K Parsons,Darshana Patel,Brij Patel,F Patel,M Patrick-Smith,Ruth O. Payne,Y Peng,E J Penn,A Pennington,M P Peralta Alvarez,B P Pereira Stuchi,A L Perez,T Perinpanathan,J Perring,R Perumal,S Y Petkar,T Philip,J Phillips,M K Phohu,L Pickup,S Pieterse,J M Pinheiro,J Piper,D Pipini,M Plank,S Plant,S Pollard,Jennifer Pooley,A Pooran,Ian D. Poulton,Claire Powers,F B Presa,Delyth Price,V Price,M R Primeira,P C Proud,Samuel Provstgaard-Morys,S Pueschel,David Pulido,S Quaid,R Rabara,K Radia,D Rajapaska,T Rajeswaran,L Ramos,Ramos Asf.,F Ramos Lopez,Tommy Rampling,J Rand,H Ratcliffe,Thomas A. Rawlinson,D Rea,B Rees,M Resuello-Dauti,E Reyes Pabon,S Rhead,Tawassal Riaz,Marivic Ricamara,A Richards,A Richter,Neil D. Ritchie,A J Robbins,H Roberts,R E Robinson,S Roche,Christine S. Rollier,Louisa Rose,A L Ross Russell,L Rossouw,S Royal,I Rudiansyah,K Ryalls,C Sabine,Stephen Saich,J C Sale,Ahmed M. Salman,N Salvador,S Salvador,Sampaio,Adel Samson,A Sanchez-Gonzalez,H Sanders,K Sanders,E Santos,Santos Guerra Mfs.,I Satti,J E Saunders,Caroline Saunders,Sayed Aba.,I Schim van der Loeff,Annina B. Schmid,E Schofield,Gavin R. Screaton,S Seddiqi,R R Segireddy,R Senger,S Serrano,Imam Shaik,Hannah Sharpe,Katherine Sharrocks,R Shaw,A Shea,E Sheehan,A Shepherd,F Shiham,S E Silk,L Silva-Reyes,Silveira Lbtd.,Silveira Mbv.,Nishanta Singh,J Sinha,D T Skelly,David Smith,Nikki Smith,H E Smith,D J Smith,Catherine C. Smith,A S Soares,C Solórzano,G L Sorio,K Sorley,T Sosa-Rodriguez,Souza Cmcdl.,Souza Bsdf.,A R Souza,T Souza Lopez,L Sowole,Alexandra J. Spencer,L Spoors,L Stafford,I Stamford,R Stein,Lisa Stockdale,L V Stockwell,L H Strickland,Arabella Stuart,A Sturdy,N Sutton,A Szigeti,Abdessamad Tahiri-Alaoui,R Tanner,C Taoushanis,Alexander W. Tarr,R Tarrant,Kathryn Mary Taylor,U Taylor,Iona J. Taylor,J Taylor,R te Water Naude,Kate Templeton,Yrene Themistocleous,Andreas C. Themistocleous,Mark G. Thomas,Kelly M. Thomas,T M Thomas,Asha Thombrayil,John R. Thompson,Fiona M. Thompson,Amber J. Thompson,K Thompson,V Thornton-Jones,Thotusi Lhs.,Patrick J. Tighe,L A Tinoco,G F Tiongson,B Tladinyane,M Tomasicchio,Adriana Tomic,Susan Tonks,J Towner,N Tran,J A Tree,G Trillana,C Trinham,R Trivett,A Truby,B L Tsheko,P Tubb,A Turabi,Richard Turner,C Turner,Nicola Turner,B Tyagi,Marta Ulaszewska,B R Underwood,S van Eck,R Varughese,D Verbart,M K Verheul,Iason Vichos,T A Vieira,G Walker,Laura L. Walker,M E Wand,T Wardell,George M. Warimwe,Simon Warren,B Watkins,Watson Mee.,E Watson,S Webb,Andrew R. Webster,J Welch,Z Wellbelove,J H Wells,A J West,Beth White,Catherine White,Rachel White,P Williams,Rachel Williams,S Willingham,R Winslow,D Woods,M Woodyer,A T Worth,Daniel B. Wright,M Wroblewska,A Yao,Yim Ytn.,M B Zambrano,R L Zimmer,D Zizi,P Zuidewind +766 more
TLDR
The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, with a regimen of two standard doses given with an interval of 4-12 weeks as discussed by the authors.About:
This article is published in The Lancet.The article was published on 2021-03-06 and is currently open access. It has received 862 citations till now. The article focuses on the topics: Booster dose & Vaccine efficacy.read more
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Journal ArticleDOI
Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant.
Shabir A. Madhi,Vicky L Baillie,Clare L. Cutland,Merryn Voysey,Anthonet Koen,Lee Fairlie,S. D. Padayachee,Keertan Dheda,S. L. Barnabas,Q. E. Bhorat,C. Briner,Gaurav Kwatra,K. Ahmed,P. Aley,Sutika Bhikha,Jinal N. Bhiman,A. ' E. Bhorat,Plessis, J. du, Esmail, A.,M. Groenewald +18 more
TL;DR: In this article, the safety and efficacy of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different populations is evaluated in different countries.
Journal ArticleDOI
Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera.
D. Zhou,Wanwisa Dejnirattisai,P Supasa,Chang Liu,Alexander J. Mentzer,Helen M. Ginn,Yuguang Zhao,Duyvesteyn Hme.,Aekkachai Tuekprakhon,R Nutalai,Beibei Wang,Guido C. Paesen,Cesar Lopez-Camacho,J Slon-Campos,Bassam Hallis,Naomi Coombes,Kevin R. Bewley,Sue Charlton,Thomas S. Walter,Donal T. Skelly,Sheila F Lumley,Christina Dold,R Levin,Tao Dong,Andrew J. Pollard,Julian C. Knight,Derrick W. Crook,Teresa Lambe,Elizabeth A. Clutterbuck,S Bibi,Amy Flaxman,M Bittaye,Sandra Belij-Rammerstorfer,Sarah C. Gilbert,William James,Miles W. Carroll,Paul Klenerman,Eleanor Barnes,Susanna Dunachie,Elizabeth E. Fry,Juthathip Mongkolsapaya,Jingshan Ren,David I. Stuart,Gavin R. Screaton +43 more
TL;DR: In this paper, a structure-function analysis of B.1.351 was performed using a large cohort of convalescent and vaccinee serum samples, and it was shown that the receptor-binding domain mutations provide tighter ACE2 binding and widespread escape from monoclonal antibody neutralization largely driven by E484K, although K417N and N501Y act together against some important antibody classes.
Journal ArticleDOI
Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in older adults in England: test negative case-control study.
James Lopez Bernal,James Lopez Bernal,James Lopez Bernal,Nick Andrews,Nick Andrews,Charlotte Gower,Chris Robertson,Julia Stowe,Elise Tessier,Ruth Simmons,Simon Cottrell,Richard J. Roberts,Mark G. O'Doherty,Kevin E. Brown,Claire Cameron,Diane Stockton,Jim McMenamin,Mary Ramsay,Mary Ramsay +18 more
TL;DR: In this paper, Pfizer-BioNTech BNT162b2 and Oxford-AstraZeneca ChAdOx1-S vaccines against confirmed covid-19 symptoms (including the UK variant of concern B.1.7), admissions to hospital, and deaths.
Journal ArticleDOI
Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection.
Shuo Feng,Daniel J. Phillips,Thomas E. White,Homesh Sayal,Parvinder K. Aley,S Bibi,Christina Dold,Michelle Fuskova,Sarah C. Gilbert,Ian Hirsch,Holly E. Humphries,Brett Jepson,Brett Jepson,Elizabeth J. Kelly,Emma Plested,Kathryn Shoemaker,Kelly M. Thomas,Johan Vekemans,Tonya Villafana,Teresa Lambe,Andrew J. Pollard,Merryn Voysey +21 more
TL;DR: In this paper, a randomized efficacy trial of the ChAdOx1 nCoV-19 (AZD1222) vaccine in the United Kingdom was analyzed to determine the antibody levels associated with protection against SARS CoV-2.
Journal ArticleDOI
Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study.
Cristina Menni,Kerstin Klaser,Anna C May,Lorenzo Polidori,Joan Capdevila,Panayiotis Louca,Carole H. Sudre,Long H. Nguyen,David A. Drew,Jordi Merino,Christina Hu,Somesh Selvachandran,Michela Antonelli,Benjamin S Murray,Liane S Canas,Erika Molteni,Mark S. Graham,Marc Modat,Amit Joshi,Massimo Mangino,Alexander Hammers,Anna Goodman,Andrew T. Chan,Jonathan Wolf,Claire J. Steves,Ana M. Valdes,Sebastien Ourselin,Tim D. Spector +27 more
TL;DR: In this article, the authors examined the proportion and probability of self-reported systemic and local side-effects within 8 days of vaccination in individuals using the COVID Symptom Study app who received one or two doses of the BNT162b2 vaccine or one dose of the ChAdOx1 nCoV-19 vaccine.
References
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Modeling the effect of boost timing in murine irradiated sporozoite prime-boost vaccines.
Cristina Fernandez-Arias,Clemente F. Arias,Min Zhang,Miguel A. Herrero,F. J. Acosta,Moriya Tsuji +5 more
TL;DR: This model suggests that boost doses and timings should be selected according to the T cell response elicited by priming, and boosting during late stages of clonal contraction would maximize T cell memory production for vaccines using lower doses of irradiated sporozoites.
Posted ContentDOI
Modelling Decay of Population Immunity With Proposed Second Dose Deferral Strategy
TL;DR: A model to project population immunity between the two strategies shows that if there is an increased decay rate of one dose efficacy relative to two dose decay rates, it is highly unlikely to nullify the benefit of increased population immunity seen in a second dose deferral strategy.
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