Single-neuron dynamics in human focal epilepsy
Wilson Truccolo,Wilson Truccolo,Wilson Truccolo,Jacob A. Donoghue,Leigh R. Hochberg,Leigh R. Hochberg,Leigh R. Hochberg,Emad N. Eskandar,Joseph R. Madsen,William S. Anderson,Emery N. Brown,Emery N. Brown,Eric Halgren,Sydney S. Cash +13 more
TLDR
In this paper, the spike train patterns of single neurons during seizures in human epilepsy patients were analyzed and it was found that spiking activity during seizure initiation was highly heterogeneous in small cortical patches and across the network.Abstract:
Epileptic seizures are traditionally considered to reflect hypersynchronous neuronal activity arising from runaway excitation. Here the authors analyze spike train patterns of single neurons during seizures in human epilepsy patients, finding that spiking activity during seizure initiation was highly heterogeneous in small cortical patches and across the network.read more
Citations
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On the nature of seizure dynamics
Viktor K. Jirsa,Viktor K. Jirsa,William C. Stacey,Pascale P. Quilichini,Pascale P. Quilichini,Anton Ivanov,Anton Ivanov,Christophe Bernard,Christophe Bernard +8 more
TL;DR: A taxonomy of seizures based on first principles is established and only five state variables linked by integral-differential equations are sufficient to describe the onset, time course and offset of ictal-like discharges as well as their recurrence.
Journal ArticleDOI
Failure mode analysis of silicon-based intracortical microelectrode arrays in non-human primates
James C. Barrese,Naveen G. Rao,Kaivon Paroo,Corey Triebwasser,Carlos E. Vargas-Irwin,Lachlan Franquemont,John P. Donoghue,John P. Donoghue +7 more
TL;DR: The results demonstrate the potential for these arrays to record for many years, but achieving reliable sensors will require replacing connectors with implantable wireless systems, controlling the meningeal reaction, and improving insulation materials.
Journal ArticleDOI
The organization of physiological brain networks.
TL;DR: This review gives an overview of modern network theory and its applications to healthy brain function and neurological disease, in particular using techniques from clinical neurophysiology, such as EEG and MEG.
Journal ArticleDOI
Synchronization and desynchronization in epilepsy: controversies and hypotheses
Premysl Jiruska,Premysl Jiruska,Premysl Jiruska,Marco de Curtis,John G. R. Jefferys,Catherine A. Schevon,Steven J. Schiff,Kaspar Schindler +7 more
TL;DR: Recent work has identified cell‐type‐specific inhibitory and excitatory interactions, the dichotomy between neuronal firing and the non‐local measurement of local field potentials distant to that firing, and the reflection of the neuronal dark matter problem in non‐firing neurons active in seizures.
Journal ArticleDOI
Evidence of an inhibitory restraint of seizure activity in humans
Catherine A. Schevon,Shennan A. Weiss,Guy M. McKhann,Robert R. Goodman,Rafael Yuste,Ronald G. Emerson,Ronald G. Emerson,Andrew J. Trevelyan +7 more
TL;DR: There is a sharp delineation between areas showing intense, hypersynchronous firing indicative of recruitment to the seizure, and adjacent territories where there is only low-level, unstructured firing, which has important implications for how to localize seizure activity and map its spread.
References
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Neuronal ensemble control of prosthetic devices by a human with tetraplegia
Leigh R. Hochberg,Leigh R. Hochberg,Mijail D. Serruya,Gerhard Friehs,Gerhard Friehs,Jon A. Mukand,Jon A. Mukand,Maryam Saleh,Abraham H. Caplan,Almut Branner,David Chen,Richard D. Penn,John P. Donoghue +12 more
TL;DR: Initial results for a tetraplegic human using a pilot NMP suggest that NMPs based upon intracortical neuronal ensemble spiking activity could provide a valuable new neurotechnology to restore independence for humans with paralysis.
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Epileptic seizures and epilepsy : Definitions proposed by the international league against epilepsy (ILAE) and the international bureau for epilepsy (IBE)
Ettore Beghi,Anne T. Berg,Arturo Carpio,Lars Forsgren,Dale C. Hesdorffer,W. Allen Hauser,Kristina Malmgren,Shlomo Shinnar,Nancy R. Temkin,David J. Thurman,Torbjörn Tomson +10 more
TL;DR: The International League Against Epilepsy (ILAE) and the International Bureau for Epilepsia (IBE) have come to consensus definitions for the terms epileptic seizure and epilepsy.
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A review of methods for spike sorting: the detection and classification of neural action potentials.
TL;DR: This article reviews algorithms and methods for detecting and classifying action potentials, a problem commonly referred to as spike sorting and discusses the advantages and limitations of each and the applicability of these methods for different types of experimental demands.