Journal ArticleDOI
Soft biological materials and their impact on cell function
Reads0
Chats0
TLDR
Biocompatible synthetic materials already have many applications, but combining chemical compatibility with physiologically appropriate mechanical properties will increase their potential for use both as implants and as substrates for tissue engineering.Abstract:
Most organs and biological tissues are soft viscoelastic materials with elastic moduli ranging from on the order of 100 Pa for the brain to 100 000 Pa for soft cartilage. Biocompatible synthetic materials already have many applications, but combining chemical compatibility with physiologically appropriate mechanical properties will increase their potential for use both as implants and as substrates for tissue engineering. Understanding and controlling mechanical properties, specifically softness, is important for appropriate physiological function in numerous contexts. The mechanical properties of the substrate on which, or within which, cells are placed can have as large an impact as chemical stimuli on cell morphology, differentiation, motility, and commitment to live or die.read more
Citations
More filters
Journal ArticleDOI
Hydrogels with tunable stress relaxation regulate stem cell fate and activity
Ovijit Chaudhuri,Ovijit Chaudhuri,Ovijit Chaudhuri,Luo Gu,Luo Gu,Darinka D. Klumpers,Darinka D. Klumpers,Darinka D. Klumpers,Max Darnell,Max Darnell,Sidi A. Bencherif,Sidi A. Bencherif,James C. Weaver,Nathaniel Huebsch,Hong-pyo Lee,Evi Lippens,Evi Lippens,Georg N. Duda,David J. Mooney,David J. Mooney +19 more
TL;DR: It is found that cell spreading, proliferation, and osteogenic differentiation of mesenchymal stem cells (MSCs) are all enhanced in cells cultured in gels with faster relaxation, highlighting stress relaxation as a key characteristic of cell-ECM interactions and as an important design parameter of biomaterials for cell culture.
Journal ArticleDOI
Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TL;DR: Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.
Journal ArticleDOI
Mechanical forces direct stem cell behaviour in development and regeneration
Kyle H. Vining,David J. Mooney +1 more
TL;DR: Fundamental insights into the mechanobiology of stem cells also inform the design of artificial niches to support stem cells for regenerative therapies.
Journal ArticleDOI
The role of matrix stiffness in regulating cell behavior.
TL;DR: This review summarizes recent data exploring the nature of matrix stiffness, mechanotransducers, and the many effects of changes in stiffness on cell function, highlighting the potential importance of these findings in understanding the biology of normal and diseased liver.
Journal ArticleDOI
Mechanics, malignancy, and metastasis: the force journey of a tumor cell.
Sanjay Kumar,Valerie M. Weaver +1 more
TL;DR: Critical steps in this “force journey,” including mechanical contributions to tissue dysplasia, invasion of the ECM, and metastasis are reviewed, and the biophysical basis of this force journey is discussed and recent advances in the measurement of cellular mechanical properties in vitro and in vivo are presented.
References
More filters
Journal ArticleDOI
Dynamic viscoelastic study for the structure of fibrin networks in the clots of blood and plasma
Makoto Kaibara,Eiichi Fukada +1 more
Journal ArticleDOI
Slow filament dynamics and viscoelasticity in entangled and active actin networks.
TL;DR: In this paper, the viscoelastic impedance of entangled actin networks and the slow conformational dynamics and diffusive motions of single filaments are analyzed by analysing the Brownian motion of attached colloidal beads, which enables independent measurements of characteristic visco-elastic response times such as the entanglement and reptation times.
Journal ArticleDOI
Melanoma cells growing in aggregates on a non-adhesive poly(HEMA) substrate exhibit polykaryocytosis but do not develop an increased metastatic capability.
TL;DR: The study has revealed a previously undescribed propensity of certain B16-F1 cells cultivated as aggregates in suspension to develop into polykaryocytes, most probably as a result of spontaneous tumor cell-tumor cell fusion.
Book ChapterDOI
The elasticity in the presence of diluents.
TL;DR: Elastin must be considered to be an amorphous, crosslinked polymer displaying rubberlike elasticity, in the absence of evidence to the contrary.
Journal ArticleDOI
Synthesis and property of hydrogel membranes consisting of fumaramate with phosphorylcholine group
TL;DR: In this paper, isopropyl-2-[trimethylammonium) ethyl phosphoryl] ethyl fumaramate (IPTPFA) was copolymerized with 2-hydroxyethylmethacrylate (HEMA) in the presence of various crosslinking agents, water, and 2,2′-azobis(isobutyronitrile) to obtain hydrogel membranes.
Related Papers (5)
Matrix elasticity directs stem cell lineage specification.
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more