Spindle assembly checkpoint activation and silencing at kinetochores
TLDR
In this article, the authors summarize current understanding of the mechanisms that activate and silence the SAC at kinetochores and highlight open questions for future investigation, including how SAC proteins are recruited to SAC in the absence of microtubule attachment.About:
This article is published in Seminars in Cell & Developmental Biology.The article was published on 2021-06-29 and is currently open access. It has received 79 citations till now. The article focuses on the topics: Kinetochore & Spindle checkpoint.read more
Citations
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The phenotypic landscape of essential human genes
Luke Funk,Kuan-Chung Su,David Feldman,Avtar Singh,Brittania Moodie,Paul C. Blainey,Iain M. Cheeseman +6 more
TL;DR: The authors combined pooled CRISPR/Cas9-based functional screening of 5,072 fitness-conferring genes in human cells with microscopy-based visualization of DNA, DNA damage, actin, and microtubules.
Journal ArticleDOI
The phenotypic landscape of essential human genes
TL;DR: In this article , the authors combined pooled CRISPR-Cas9-based functional screening of 5,072 fitness-conferring genes in human HeLa cells with microscopy-based imaging of DNA, the DNA damage response, actin, and microtubules.
Journal ArticleDOI
The four causes: the functional architecture of centromeres and kinetochores
TL;DR: This work proposes a model for how this ensemble-level architecture is organized, drawing on key insights from the simple one microtubule-one kinetochore setup in budding yeast and innovations that enable meiotic chromosome segregation.
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Aurora B Tension Sensing Mechanisms in the Kinetochore Ensure Accurate Chromosome Segregation.
TL;DR: In this paper, the role of the Aurora B kinase in tension-sensing and the current models for translating mechanical force into Aurora B mediated biochemical signals that regulate correction of chromosome attachments to the spindle.
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The Multifaceted Regulation of Mitochondrial Dynamics During Mitosis.
Evanthia Pangou,Izabela Sumara +1 more
TL;DR: In this paper, a review aims at summarizing established and emerging concepts about the complex regulatory networks which couple crucial mitotic factors and events to mitochondrial dynamics and which could be implicated in human disease.
References
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Journal ArticleDOI
Feedback control of mitosis in budding yeast.
Rong Li,Andrew W. Murray +1 more
TL;DR: The role of feedback controls in coordinating events in the cell cycle is discussed and the properties of mad mutants indicate that they are defective in the feedback control over the exit from mitosis are discussed.
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The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.
Silke Hauf,Richard W. Cole,Sabrina LaTerra,Christine Zimmer,Gisela Schnapp,Rainer Walter,Armin Heckel,Jacques van Meel,Conly L. Rieder,Jan-Michael Peters +9 more
TL;DR: The data suggest that Aurora B is required to generate unattached kinetochores on monooriented chromosomes, which in turn could promote bipolar attachment as well as maintain checkpoint signaling.
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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
Claire Ditchfield,Victoria L. Johnson,Anthony Tighe,Rebecca Ellston,Carolyn Haworth,Trevor Johnson,Andrew A. Mortlock,Nicholas Keen,Stephen S. Taylor +8 more
TL;DR: It is shown that BubR1 is not only required for spindle checkpoint function, but is also required for chromosome alignment, which suggests that by targeting checkpoint proteins to kinetochores, Aurora B couples chromosome alignment with anaphase onset.
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S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function.
M.A. Hoyt,L. Totis,B.T. Roberts +2 more
TL;DR: In this article, the authors identified mutant strains of S. cerevisiae that fail to properly arrest their cell cycles at mitosis in response to the loss of microtubule function.
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Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
TL;DR: It is proposed that the preformed interphase pool of MCC allows for rapid inhibition of APC/C when cells enter mitosis, and this likely contributes to the lag in ubiquitin ligase activity.