Spine Dynamics: Are They All the Same?
TLDR
This review re-evaluate the validity of using spine dynamics as a straightforward reflection of circuit rewiring, and discusses distinct roles that spine dynamics can play in circuit remodeling depending on synaptic content.About:
This article is published in Neuron.The article was published on 2017-09-27 and is currently open access. It has received 327 citations till now. The article focuses on the topics: Dendritic spine & Dendritic filopodia.read more
Citations
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Dendritic Structural Plasticity and Neuropsychiatric Disease
TL;DR: The importance of recent genetic findings on the different mechanisms of structural plasticity are discussed and it is proposed that these converge on shared pathways that can be targeted with novel therapeutics.
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A Synaptic Perspective of Fragile X Syndrome and Autism Spectrum Disorders.
TL;DR: It is inferred that there is no single pathway that explains most of the etiology of fragile X syndrome and related ASDs, and new findings and the implications for future work directed at improving the understanding of the pathogenesis and the design of therapeutic strategies to ameliorate these disorders.
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Phase separation at the synapse
TL;DR: Recent developments showing how phase separation can build dense synaptic molecular clusters are reviewed, highlight unique features of such condensed clusters in the context of synaptic development and signaling, and discuss how aberrant phase-separation-mediated synaptic assembly formation may contribute to dysfunctional signaling in psychiatric disorders are reviewed.
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Sleep and synaptic down-selection
Giulio Tononi,Chiara Cirelli +1 more
TL;DR: The synaptic homeostasis hypothesis (SHY) as discussed by the authors proposes that sleep is the price the brain pays for plasticity, to consolidate what we already learned, and be ready to learn new things the next day.
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Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism
Lucas Cheadle,Samuel Rivera,Jasper S. Phelps,Katelin A. Ennis,Beth Stevens,Linda C. Burkly,Wei-Chung Allen Lee,Michael E. Greenberg +7 more
TL;DR: It is found that visual experience alters the number and structure of synapses between the retina and the thalamus, and TWEAK and Fn14 represent an intercellular signaling axis through which microglia shape retinogeniculate connectivity in response to sensory experience.
References
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TL;DR: The measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits.
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