Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study
Jae-Hoon Song,Po-Ren Hsueh,Doo Ryeon Chung,Kwan Soo Ko,Cheol-In Kang,Kyong Ran Peck,Joon Sup Yeom,Shin Woo Kim,Hyun-Ha Chang,Yeon Sook Kim,Sook-In Jung,Jun Seong Son,Thomas Man-kit So,M. K. Lalitha,Yonghong Yang,Shao-Guang Huang,Hui Wang,Quan Lu,Celia C. Carlos,Jennifer Perera,Cheng-Hsun Chiu,Jien-Wei Liu,Anan Chongthaleong,Visanu Thamlikitkul,Pham Hung Van,Hyuck Lee,Thomas M. K. So,David Jien-Wei Liu,Dilip Mathai,Jennifer Perera,Tran Van Ngoc +30 more
TLDR
It is confirmed that MRSA infections in the community have been increasing in Asian countries and data suggest that various MRSA clones have spread between the community and hospitals as well as between countries.Abstract:
Objectives Methicillin-resistant Staphylococcus aureus (MRSA) is highly prevalent in hospitals in many Asian countries. Recent emergence of community-associated (CA) MRSA worldwide has added another serious concern to the epidemiology of S. aureus infections. To understand the changing epidemiology of S. aureus infections in Asian countries, we performed a prospective, multinational surveillance study with molecular typing analysis. Methods We evaluated the prevalence of methicillin resistance in S. aureus isolates in CA and healthcare-associated (HA) infections, and performed molecular characterization and antimicrobial susceptibility tests of MRSA isolates. Results MRSA accounted for 25.5% of CA S. aureus infections and 67.4% of HA infections. Predominant clones of CA-MRSA isolates were ST59-MRSA-SCCmec type IV-spa type t437, ST30-MRSA-SCCmec type IV-spa type t019 and ST72-MRSA-SCCmec type IV-spa type t324. Previously established nosocomial MRSA strains including sequence type (ST) 239 and ST5 clones were found among CA-MRSA isolates from patients without any risk factors for HA-MRSA infection. CA-MRSA clones such as ST59, ST30 and ST72 were also isolated from patients with HA infections. Conclusions Our findings confirmed that MRSA infections in the community have been increasing in Asian countries. Data also suggest that various MRSA clones have spread between the community and hospitals as well as between countries.read more
Citations
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Journal ArticleDOI
Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.
Nicholas A Turner,Batu K. Sharma-Kuinkel,Stacey A. Maskarinec,Emily M. Eichenberger,Pratik Shah,Manuela Carugati,Manuela Carugati,Thomas L. Holland,Vance G. Fowler,Vance G. Fowler +9 more
TL;DR: An overview of basic and clinical MRSA research is provided and the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA is explored.
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Access to effective antimicrobials: a worldwide challenge.
Ramanan Laxminarayan,Ramanan Laxminarayan,Precious Matsoso,Suraj Pant,Charles H. Brower,John-Arne Røttingen,John-Arne Røttingen,Keith P. Klugman,Sally C Davies +8 more
TL;DR: The disease burden caused by limited access to antimicrobials, attributable to resistance to antimicrobial resistance, and the potential effect of vaccines in restricting the need for antibiotics are assessed.
Journal ArticleDOI
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology
Sahreena Lakhundi,Kunyan Zhang +1 more
TL;DR: The origin of MRSA is described, with emphasis on the diverse nature of staphylococcal cassette chromosome mec (SCCmec).
Journal ArticleDOI
Antimicrobial resistance in ESKAPE pathogens
David M. P. De Oliveira,Brian M. Forde,Timothy J. Kidd,Patrick N A Harris,Mark A. Schembri,Scott A. Beatson,David L. Paterson,Mark J. Walker +7 more
TL;DR: The acquisition of antimicrobial resistance genes by ESKAPE pathogens has reduced the treatment options for serious infections, increased the burden of disease, and increased death rates due to treatment failure and requires a coordinated global response for antim antibiotic resistance surveillance.
Journal ArticleDOI
Meticillin-resistant Staphylococcus aureus (MRSA): global epidemiology and harmonisation of typing methods
Stefania Stefani,Doo Ryeon Chung,Jodi A. Lindsay,Alexander W. Friedrich,Angela M. Kearns,Henrik Westh,Fiona M. MacKenzie +6 more
TL;DR: The group consensus was to recommend spa and staphylococcal cassette chromosome mec (SCCmec) typing as the preferred methods for MRSA, which are informative in defining particular strain characteristics and utilise standardised nomenclatures, making them applicable globally.
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Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management
Dag Harmsen,Heike Claus,Wolfgang Witte,Jörg Rothgänger,Hermann Claus,Doris Turnwald,Ulrich Vogel +6 more
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