Journal ArticleDOI
Strategies to increase nitric oxide signalling in cardiovascular disease
Reads0
Chats0
TLDR
This Review discusses the identification of new pathways for enhancing NO synthase activity; ways to amplify the nitrate–nitrite–NO pathway; novel classes of NO-donating drugs; drugs that limit NO metabolism through effects on reactive oxygen species; and ways to modulate downstream phosphodiesterases and soluble guanylyl cyclases.Abstract:
Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central nervous systems, and crucial steps in the regulation of NO bioavailability in health and disease are well characterized. Although early approaches to therapeutically modulate NO bioavailability failed in clinical trials, an enhanced understanding of fundamental subcellular signalling has enabled a range of novel therapeutic approaches to be identified. These include the identification of: new pathways for enhancing NO synthase activity; ways to amplify the nitrate-nitrite-NO pathway; novel classes of NO-donating drugs; drugs that limit NO metabolism through effects on reactive oxygen species; and ways to modulate downstream phosphodiesterases and soluble guanylyl cyclases. In this Review, we discuss these latest developments, with a focus on cardiovascular disease.read more
Citations
More filters
Journal ArticleDOI
P3461 Physical training increases endothelial progenitor cells, inhibits neointima formation and enhances angiogenesis
TL;DR: Physical activity increases the production and circulating numbers of EPCs via a partially NO-dependent, antiapoptotic effect that could potentially underlie exercise-related beneficial effects on cardiovascular diseases.
Book
Physiology and pathophysiology
Wen-Quan Zou,Pierluigi Gambetti +1 more
TL;DR: The author examines the role of Cellular Prion Protein in the Amyloid-ss Oligomer Pathophysiology of Alzheimer's Disease, as well as modeling the Cell Biology of Prions and Yeast Prions.
Journal ArticleDOI
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
TL;DR: The biology of NO and ROS in the cardiovascular system, with special emphasis on their routes of formation and regulation, are presented, as well as the therapeutic challenges and opportunities for the management of no/ROS in cardiovascular disease.
Journal ArticleDOI
Pathophysiology of Sickle Cell Disease.
TL;DR: This review provides an exhaustive overview of the current understanding of the molecular pathophysiology of SCD, how this pathophysiological contributes to complications of the central nervous and cardiopulmonary systems, and how this knowledge is being harnessed to develop current and potential therapies.
Journal ArticleDOI
The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine.
Miriam M. Cortese-Krott,Anne M. Koning,Gunter G. C. Kuhnle,Péter Nagy,Christopher L. Bianco,Christopher L. Bianco,Andreas Pasch,David A. Wink,Jon M. Fukuto,Jon M. Fukuto,Jon M. Fukuto,Alan Jackson,Harry van Goor,Kenneth R. Olson,Martin Feelisch +14 more
TL;DR: This work introduces a novel integrative concept defined as the reactive species interactome (RSI), a primeval multilevel redox regulatory system whose architecture allows efficient sensing and rapid adaptation to environmental changes and various other stressors to enhance fitness and resilience at the local and whole-organism level.
References
More filters
Journal Article
Nitric oxide: physiology, pathophysiology, and pharmacology
Journal ArticleDOI
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
TL;DR: It is demonstrated that relaxation of isolated preparations of rabbit thoracic aorta and other blood vessels by ACh requires the presence of endothelial cells, and that ACh, acting on muscarinic receptors of these cells, stimulates release of a substance(s) that causes relaxation of the vascular smooth muscle.
Journal ArticleDOI
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
TL;DR: NO released from endothelial cells is indistinguishable from EDRF in terms of biological activity, stability, and susceptibility to an inhibitor and to a potentiator.
Journal ArticleDOI
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.
TL;DR: It is proposed that superoxide dismutase may protect vascular tissue stimulated to produce superoxide and NO under pathological conditions by preventing the formation of peroxynitrite.
Journal ArticleDOI
The L-Arginine-Nitric Oxide Pathway
Salvador Moncada,Annie Higgs +1 more
TL;DR: The discovery that mammalian cells generate nitric oxide, a gas previously considered to be merely an atmospheric pollutant, is providing important information about many biologic processes.
Related Papers (5)
The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation.
Nitrate and nitrite in biology, nutrition and therapeutics
Jon O. Lundberg,Mark T. Gladwin,Amrita Ahluwalia,Nigel Benjamin,Nathan S. Bryan,Anthony R. Butler,Pedro Cabrales,Angela Fago,Martin Feelisch,Peter C. Ford,Bruce A. Freeman,Michael P. Frenneaux,Joel M. Friedman,Malte Kelm,Christopher G. Kevil,Daniel B. Kim-Shapiro,Andrey V. Kozlov,Jack R. Lancaster,David J. Lefer,Kenneth E.L. McColl,Kenneth R. McCurry,Rakesh P. Patel,Joel Petersson,Tienush Rassaf,Valentin Reutov,George B. Richter-Addo,Alan N. Schechter,Sruti Shiva,Koichiro Tsuchiya,Ernst E. van Faassen,Andrew J. Webb,Brian S. Zuckerbraun,Jay L. Zweier,Eddie Weitzberg +33 more