Journal ArticleDOI
Structural dynamics of dendritic spines in memory and cognition
TLDR
The onset of long-term potentiation, spine-volume growth and an increase in receptor trafficking are coincident, enabling a 'functional readout' of spine structure that links the age, size, strength and lifetime of a synapse.About:
This article is published in Trends in Neurosciences.The article was published on 2010-03-01. It has received 759 citations till now. The article focuses on the topics: Dendritic spine & Long-term potentiation.read more
Citations
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Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
TL;DR: Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.
Journal ArticleDOI
Dendritic spine pathology in neuropsychiatric disorders
TL;DR: This work discusses recent neuropathological, genetic, molecular and animal model studies that implicate structural alterations at spiny synapses in the pathogenesis of major neurological disorders, focusing on ASD, schizophrenia and Alzheimer's disease as representatives of these categories across different ages of onset.
Journal ArticleDOI
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy
Millan Mark,Yves Agid,Martin Brüne,Edward T. Bullmore,Cameron S. Carter,Nicola S. Clayton,Richard C. Connor,Sabrina Davis,Bill Deakin,Robert J. DeRubeis,Bruno Dubois,Mark A. Geyer,Guy M. Goodwin,Philip Gorwood,Thérèse M. Jay,Marian Joëls,Isabelle M. Mansuy,Andreas Meyer-Lindenberg,Declan G. Murphy,Edmund T. Rolls,Bernd Saletu,Michael Spedding,John A. Sweeney,Miles A. Whittington,Larry J. Young +24 more
TL;DR: This article critically discusses the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders, highlighting the needs to characterize the cellular and cerebral circuits underpinning cognitive function and identify more effective treatments.
Journal ArticleDOI
Molecular Mechanisms of Fear Learning and Memory
Joshua P. Johansen,Christopher K. Cain,Christopher K. Cain,Linnaea E. Ostroff,Joseph E. LeDoux,Joseph E. LeDoux +5 more
TL;DR: This work discusses the neurotransmitter systems and signaling cascades that contribute to three phases of auditory fear conditioning: acquisition, consolidation, and reconsolidation and suggests that multiple intracellular signaling pathways interact to produce neural plasticity in the LA and behavioral fear conditioning.
Journal ArticleDOI
NMDA Receptor-Dependent Long-Term Potentiation and Long-Term Depression (LTP/LTD)
TL;DR: The investigation of the molecular and cellular mechanisms underlying these forms of synaptic plasticity has received much attention, because NMDA receptor-dependent LTP and LTD may constitute cellular substrates of learning and memory.
References
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Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Book
Numerical Solution of Stochastic Differential Equations
Peter E. Kloeden,Eckhard Platen +1 more
TL;DR: In this article, a time-discrete approximation of deterministic Differential Equations is proposed for the stochastic calculus, based on Strong Taylor Expansions and Strong Taylor Approximations.
Journal ArticleDOI
Receptive fields of single neurones in the cat's striate cortex
David H. Hubel,Torsten N. Wiesel +1 more
TL;DR: The present investigation, made in acute preparations, includes a study of receptive fields of cells in the cat's striate cortex, which resembled retinal ganglion-cell receptive fields, but the shape and arrangement of excitatory and inhibitory areas differed strikingly from the concentric pattern found in retinalganglion cells.
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