Journal ArticleDOI
Structure and Function of Simian Virus 40 Large Tumor Antigen
Ellen Fanning,Rolf Knippers +1 more
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This article is published in Annual Review of Biochemistry.The article was published on 1992-01-01. It has received 492 citations till now. The article focuses on the topics: Virus & Antigen.read more
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Reversal of human cellular senescence: roles of the p53 and p16 pathways
Christian Beauséjour,Ana Krtolica,Francesco Galimi,Francesco Galimi,Masashi Narita,Scott W. Lowe,Paul Yaswen,Judith Campisi,Judith Campisi +8 more
TL;DR: The results indicate that the senescence response to telomere dysfunction is reversible and is maintained primarily by p53, however, p16 provides a dominant second barrier to the unlimited growth of human cells.
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Helicases: amino acid sequence comparisons and structure-function relationships
TL;DR: Three large superfamilies and two smaller families of helicases are described and experimental results support the value of the conserved motifs for prediction of structure and function of the helicases.
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The dna replication fork in eukaryotic cells
Shou Waga,Bruce Stillman +1 more
TL;DR: Biochemical studies, principally of plasmid DNAs containing the Simian Virus 40 origin of DNA replication, and yeast genetic studies have uncovered the fundamental mechanisms of replication fork progression.
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Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation
William C. Hahn,Scott K. Dessain,Scott K. Dessain,Mary W. Brooks,Jessie E. King,Brian Elenbaas,David M. Sabatini,James A. DeCaprio,Robert A. Weinberg +8 more
TL;DR: Observations define the elements of the SV40 ER required for the transformation of human cells and begin to delineate a set of intracellular pathways whose disruption, in aggregate, appears to be necessary to generate tumorigenic human cells.
Journal ArticleDOI
Recombinant replication protein A: expression, complex formation, and functional characterization.
TL;DR: Recombinant human RPA has the same subunit composition and the same activities as the authentic complex from human cells and is capable of supporting SV40 DNA replication in vitro.