Journal ArticleDOI
Structure of FK506, a novel immunosuppressant isolated from Streptomyces
Hirokazu Tanaka,Akio Kuroda,Hiroshi Marusawa,Hiroshi Hatanaka,Toru Kino,Toshio Goto,Masashi Hashimoto,Toru Taga +7 more
About:
This article is published in Journal of the American Chemical Society.The article was published on 1987-08-01. It has received 523 citations till now. The article focuses on the topics: Streptomyces tsukubaensis & Streptomyces.read more
Citations
More filters
Journal ArticleDOI
Alkylation of chiral prolinol propionamide enolates with epoxides: Complete reversal of predicted facial selectivity
TL;DR: The title transformation provided a rapid and efficient synthesis of syn and anti 2-methyl-4-hydroxylcarboxylic ester arrays as mentioned in this paper, which was used for the first time in 1989.
Journal ArticleDOI
Double Carbonylation Reactions: Overview and Recent Advances
Journal ArticleDOI
Synthesis of Vicinal Trioxo Compounds by Dimethyl Dioxirane Oxidation of 2-Diazo-1,3-dioxo Derivatives
TL;DR: In this article, a convenient preparation of vicinal triketones, α,β-dioxoesters and 2-oxomalonates is described, which can be used for any chemical compound.
Journal ArticleDOI
Construction of a 3D-shaped, natural product like fragment library by fragmentation and diversification of natural products.
Horst Prescher,Guido Koch,Tim Schuhmann,Peter Ertl,Alex Bussenault,Meir Glick,Ina Dix,Frank Petersen,Dimitrios Lizos +8 more
TL;DR: The obtained fragment library has an excellent 3D-shape and natural product likeness, covering a novel, unexplored and underrepresented chemical space in fragment based drug discovery (FBDD).