Journal ArticleDOI
Structure of FK506, a novel immunosuppressant isolated from Streptomyces
Hirokazu Tanaka,Akio Kuroda,Hiroshi Marusawa,Hiroshi Hatanaka,Toru Kino,Toshio Goto,Masashi Hashimoto,Toru Taga +7 more
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This article is published in Journal of the American Chemical Society.The article was published on 1987-08-01. It has received 523 citations till now. The article focuses on the topics: Streptomyces tsukubaensis & Streptomyces.read more
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Journal ArticleDOI
Application of coil centrifugal counter-current chromatography to the separation of macrolide antibiotic analogues III. Effects of flow-rate, mass load and rotation speed on the peak resolution.
TL;DR: The results show that the retention percentage of the stationary phase has linear relationships with both flow-rate at 1 to 3 ml/min and rotation speed at 100 to 700 rpm, but their correlation coefficients are negative (-1.000) and positive (0.9821).
Journal ArticleDOI
Novel derivatives at the C21 position of the FK-506 macrocycle
Helen M. Organ,Mark A. Holmes,Judith M. Pisano,Mary Jo Staruch,Matthew J. Wyvratt,Francis J. Dumont,Peter J. Sinclair +6 more
TL;DR: In this paper, a number of derivatives of FK-506 were prepared and their immunosuppressant properties evaluated in a T-cell proliferation assay, and some of these compounds are surprisingly potent antagonists of Fk-506-mediated immuno-suppression.
Journal ArticleDOI
Aerobic oxidative amidation of alkynes using titanium oxide encapsulated cuprous iodide nanoparticles (CuI@TiO2)
TL;DR: In this article, a catalyst consisting of titanium oxide encapsulated cuprous iodide nanoparticles was prepared via a sol-gel method using inexpensive raw materials and was harnessed successfully in the oxidative amidation of alkynes via an environmentally benign and sustainable protocol.
Book ChapterDOI
Chapter 22. Mechanism-Based Immunosuppressants
TL;DR: While macrocyclic immunosuppressants exert their effects through a variety of paths, the total elucidation and refinement of their mechanism(s) of action are ongoing, and the utility of traditional, clinically used immuno-pharmaceuticals is largely limited to transplantation.
Journal ArticleDOI
Thermal rearrangement of the immunosuppressant fk-506
Hyun O. Ok,Byron H. Arison,Richard G. Ball,Thomas R. Beattie,M. H. Fisher,Matthew J. Wyvratt +5 more
TL;DR: In this article, FK-506 in xylene at reflux results in a [3,3] sigmropic rearrangement of the allylic ester portion of the molecule to give a new ring expanded macrolide.