Journal ArticleDOI
Structure of FK506, a novel immunosuppressant isolated from Streptomyces
Hirokazu Tanaka,Akio Kuroda,Hiroshi Marusawa,Hiroshi Hatanaka,Toru Kino,Toshio Goto,Masashi Hashimoto,Toru Taga +7 more
About:
This article is published in Journal of the American Chemical Society.The article was published on 1987-08-01. It has received 523 citations till now. The article focuses on the topics: Streptomyces tsukubaensis & Streptomyces.read more
Citations
More filters
Journal ArticleDOI
Synthesis of tricyclic N,O-acetals from α-functionalized rubanone. A masked 1,2,3-tricarbonyl system from quinidine
TL;DR: In this article, a series of protected 2-bromorubanones derived from quinidine has been prepared diastereoselectively and converted into tricyclic N,O-acetals containing a masked 1,2,3-tricarbonyl functionality.
Patent
Heterocyclic thioesters or ketones for vision and memory disorders
TL;DR: In this article, the authors proposed a method for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using heterocyclic thioesters and ketones.
Journal ArticleDOI
1H-NMR determination of the solution structure and absolute configuration of FR134043, a novel inhibitor of human leukocyte elastase
TL;DR: The simulated annealing calculation described here is a frequently used method for the determination of the solution structure of peptides or small proteins and is also applicable to the determined of the absolute configuration of macrocyclic compounds produced from natural sources.
Journal ArticleDOI
Analogues of AVP modified in the N-terminal part of the molecule with Pip isomers: TFA-catalysed peptide bond hydrolysis.
TL;DR: Both the analogues of AVP and [Mpa1]AVP with identical substituents at position 2 turned out to be highly sensitive to TFA used for deprotection and cleavage of the synthesised peptides from the resin and it was the reason why the authors were not able to obtain these four peptides.
Patent
N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
TL;DR: In this paper, pharmaceutical compositions and methods for treating alopecia and promoting hair growth using N-linked ureas or carbamates of heterocyclic thioesters are described.