Journal ArticleDOI
Structure of FK506, a novel immunosuppressant isolated from Streptomyces
Hirokazu Tanaka,Akio Kuroda,Hiroshi Marusawa,Hiroshi Hatanaka,Toru Kino,Toshio Goto,Masashi Hashimoto,Toru Taga +7 more
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This article is published in Journal of the American Chemical Society.The article was published on 1987-08-01. It has received 523 citations till now. The article focuses on the topics: Streptomyces tsukubaensis & Streptomyces.read more
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Journal ArticleDOI
C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study.
Mark T. Goulet,Peter J. Sinclair,Frederick Wong,Mary Jo Staruch,Francis J. Dumont,John G. Cryan,Gregory J. Wiederrecht,Matthew J. Wyvratt,William H. Parsons +8 more
TL;DR: A tether length study of C32-O-phenalkyl ether derivatives of ascomycin was conducted and it was determined that a 2-carbon tether provides optimum in vitro immunosuppressive activity.
Patent
Microbial transformation product of l-679,934
TL;DR: In this article, a new immunosuppressant, L-683,519, a monodemethylated rearranged derivative of L-679,934, produced under fermentation conditions utilizing the microorganism, unidentified Actinomycete (Merck Culture Collection MA 6474) ATCC No. 53828.
Journal ArticleDOI
Effect of rotavirus on serum tacrolimus level in pediatric liver transplant recipients.
TL;DR: The patient underwent a liver transplant in which she received the left lateral liver segments from her mother at the age of 2.5 years, due to progressive familial intrahepatic cholestasis (PFIC), and was hospitalised due to diarrhea nine months after transplantation.
Book ChapterDOI
Development of Tacrolimus Ointment
T. Goto,H. Nakagawa +1 more
TL;DR: Many antibiotics, in addition to other antimicrobials, enzymes, enzyme inhibitors and immunomodulatory agents have also been isolated from microbial fermentation products, including penicillin, which was isolated from the bread mould Penicillium notatum by Fleming in 1929.
Journal ArticleDOI
Terminally Protected 1-Phenyl-1,5-hexadiyne-3,4-diones as First Members of the Class of Dialkynyl-1,2-diones
Rüdiger Faust,Christian Weber +1 more
TL;DR: In this article, the first dialkynyl-1,2-diones were derived from 1-ethoxy-3-phenyl-prop-2-ynyl (1H-benzotriazole) with various acetylenic aldehydes.