Journal ArticleDOI
Structure of FK506, a novel immunosuppressant isolated from Streptomyces
Hirokazu Tanaka,Akio Kuroda,Hiroshi Marusawa,Hiroshi Hatanaka,Toru Kino,Toshio Goto,Masashi Hashimoto,Toru Taga +7 more
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This article is published in Journal of the American Chemical Society.The article was published on 1987-08-01. It has received 523 citations till now. The article focuses on the topics: Streptomyces tsukubaensis & Streptomyces.read more
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Neurotrophe Naturstoffe - ihre Chemie und Biologie
TL;DR: Neurodegenerative Erkrankungen and Ruckenmarksverletzungen betreffen weltweit etwait approximately 50 million people and verursachen Gesundheitskosten of insgesamt mehr als 600 million dollars per year as mentioned in this paper.
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Synthesis and conformational analysis of peptides embodying 2,3-methanopipecolic acids
Luciano Ricci,Lorenzo Sernissi,Dina Scarpi,Francesca Bianchini,Alessandro Contini,Ernesto G. Occhiato +5 more
TL;DR: Given the importance of the proline cis/trans isomerism in many biological processes, CPAs could be useful as proline mimetics for probing protein-ligand interactions and generating novel bioactive compounds.
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Effects of FK506 on Ca 2+ Release Channels (Review)
TL;DR: Tacrolimus (FK506), which was isolated from the fermentation broth of Streptomyces tsukubaensis No. 9993, has an immunosuppressive effect in T-lymphocytes and muscle cells, and it was found that FK506 itself induces Ca2+ release through RyRs in some tissues.
Journal ArticleDOI
Original Article: Cyclosporine a and FK 506 Affect Platelet Functions in Vitro.
TL;DR: CyA at every concentration studied resulted in dose-dependent enhancement in ADP-induced platelet aggregation in whole blood, whereas platelet responses to other agonists were found to be increased only with the highest concentration of CyA together with ATP release.
Journal ArticleDOI
Isolation and characterization of the major equilibrium product of FK-520.
Francis P. Gailliot,Theresa K. Natishan,John M. Ballard,Robert A. Reamer,Dennis Kuczynski,G. J. Mcmanemin,Richard S. Egan,Barry C. Buckland +7 more
TL;DR: The existence of an isomeric form in equilibrium with the major component of FK-520 in polar solutions has been demonstrated and this minor component has been isolated in high yield and purity by a novel crystallization strategy and preparative HPLC.