Journal ArticleDOI
Structure of FK506, a novel immunosuppressant isolated from Streptomyces
Hirokazu Tanaka,Akio Kuroda,Hiroshi Marusawa,Hiroshi Hatanaka,Toru Kino,Toshio Goto,Masashi Hashimoto,Toru Taga +7 more
About:
This article is published in Journal of the American Chemical Society.The article was published on 1987-08-01. It has received 523 citations till now. The article focuses on the topics: Streptomyces tsukubaensis & Streptomyces.read more
Citations
More filters
Journal ArticleDOI
Probing the biology of natural products: molecular editing by diverted total synthesis.
TL;DR: This Review assembles a collection of classic and current cases that illustrate and underscore the scientific possibilities for practitioners of chemical synthesis.
Journal ArticleDOI
The C7H6 Potential Energy Surface Revisited: Relative Energies and IR Assignment
TL;DR: In this paper, the geometries and force fields of phenylcarbene and cycloheptatrienylidene (CHT) in their singlet and triplet electronic states as well as of CHTE and bicyclo[4.1.0]heptatriene and the transition states for the formation and decay of the latter were evaluated by various methods.
Journal ArticleDOI
Organische Synthese — wohin?
TL;DR: In this article, a survey of the state-of-the-art Synthese-methoden is presented, e.g., enantioselektiven Herstellung bestimmter Verbindungen verwendet, enzyme, Enzyme, ganze Mikroorganismen or Zellkulturen.
Journal ArticleDOI
Comparative Clinical Pharmacokinetics of Tacrolimus in Paediatric and Adult Patients
TL;DR: The rate and extent of tacrolimus absorption after oral administration do not seem to be altered in paediatric patients, but oral doses need to be generally 2-fold higher than corresponding adult doses to reach similar tacolimus blood concentrations.
Journal ArticleDOI
Recent Developments in General Methodologies for the Synthesis of α-Ketoamides
TL;DR: An overview of the diverse methodologies that have emerged since the 1990s up to the present regarding the synthesis of α-ketoamide compounds by palladium-catalyzed double-carbonylative amination reactions is discussed.