Journal ArticleDOI
Structure of FK506, a novel immunosuppressant isolated from Streptomyces
Hirokazu Tanaka,Akio Kuroda,Hiroshi Marusawa,Hiroshi Hatanaka,Toru Kino,Toshio Goto,Masashi Hashimoto,Toru Taga +7 more
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This article is published in Journal of the American Chemical Society.The article was published on 1987-08-01. It has received 523 citations till now. The article focuses on the topics: Streptomyces tsukubaensis & Streptomyces.read more
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Synthesis of the cyclohexyl fragment of FK-506 by intramolecular ene-reaction
Martin E. Maier,Bäbel Schöffling +1 more
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Metal free synthesis of α-keto amides from 2-hydroxy acetophenones through domino alcohol oxidation–oxidative amidation reaction
TL;DR: An efficient method for the synthesis of α-keto amides using 2-iodoxybenzoic acid (IBX) promoted domino alcohol oxidation and oxidative amidation reaction sequence between 2-oxoalcohols and amines under metal-free conditions is developed in this article.
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The chemistry of ascomycin: Structure determination and synthesis of pyrazole analogues
Yat Sun Or,Richard F. Clark,Qinghua Xie,James B. McAlpine,David N. Whittern,Rodger F. Henry,Jay R. Luly +6 more
TL;DR: Ascomycin is a close analogue of the immunosuppressant FK-506 which differs slightly in the side chain at position 21 (ethyl vs allyl) as discussed by the authors.
Journal ArticleDOI
An efficient, asymmetric synthesis of pipecolic acid and 2-alkyl pipecolic acids
TL;DR: Both (R)- and (S)-pipecolic acids and their 2-alkyl derivatives have been synthesized via diastereoselective alkylations of 5-phenylmorpholin-2-one 5.
Journal ArticleDOI
Some transformations of tacrolimus, an immunosuppressive drug.
Dorthe Mondrup Skytte,Jerzy W. Jaroszewski,Kenneth T. Johansen,Steen Honoré Hansen,Liselotte Hansen,Peter G. Nielsen,Karla Frydenvang +6 more
TL;DR: Transformations of the macrocyclic lactone tacrolimus, an important immunosuppressive drug produced by Streptomyces species, are described, and these transformation products are primarily of interest as reference substances for drug impurity analyses.