Journal ArticleDOI
Structure of FK506, a novel immunosuppressant isolated from Streptomyces
Hirokazu Tanaka,Akio Kuroda,Hiroshi Marusawa,Hiroshi Hatanaka,Toru Kino,Toshio Goto,Masashi Hashimoto,Toru Taga +7 more
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This article is published in Journal of the American Chemical Society.The article was published on 1987-08-01. It has received 523 citations till now. The article focuses on the topics: Streptomyces tsukubaensis & Streptomyces.read more
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Flexible Molecules with Defined Shape—Conformational Design
TL;DR: The importance of molecular shape was recognized perhaps for the first time by the semio-chemists, who were interested in the interactions of fragrant substances with a receptor as mentioned in this paper.
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Multifunctional organoboron compounds for scalable natural product synthesis
TL;DR: A facile multicomponent catalytic process that begins with a chemoselective, site-selective and diastereoselectively copper–boron addition to a monosubstituted allene and the resulting boron-substituting organocopper intermediates then participate in a similarly selective allylic substitution.
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Fingolimod (FTY720): A Recently Approved Multiple Sclerosis Drug Based on a Fungal Secondary Metabolite
TL;DR: Fingolimod is orally active, which is unique among current first-line MS therapies, and it has the potential to be used in the treatment of organ transplants and cancer.
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FK-506--how much potential?
TL;DR: The immunological properties of FK-506 are reviewed, its potential in the light of the impact already made by CsA is assessed and its two agents can act synergistically both in vivo and in vitro.