Journal ArticleDOI
Structure of FK506, a novel immunosuppressant isolated from Streptomyces
Hirokazu Tanaka,Akio Kuroda,Hiroshi Marusawa,Hiroshi Hatanaka,Toru Kino,Toshio Goto,Masashi Hashimoto,Toru Taga +7 more
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This article is published in Journal of the American Chemical Society.The article was published on 1987-08-01. It has received 523 citations till now. The article focuses on the topics: Streptomyces tsukubaensis & Streptomyces.read more
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Book ChapterDOI
Recent Progress in Research on the Immunosuppressant FK-506
TL;DR: In this paper, a single-crystal X-ray analysis of FK-506 has been performed and the relative configuration of the stereogenic centers has been determined by NMR spectroscopy.
Book ChapterDOI
Methods for the Chemical Synthesis of Noncoded α‐Amino Acids found in Natural Product Peptides
Journal ArticleDOI
Novel synthesis of oxoacetamides via reaction of salicylaldehyde and isocyanide under mild reaction condition.
TL;DR: A convenient procedure for the formation of oxoacetamides derivatives is reported via the reaction of salicylaldehyde and alkyl isocyanide in a simple process without the use of any catalyst or metal promoters in DCM at room temperature.
Journal ArticleDOI
Effect of donor-specific transfusion in combination with FK 506 in rat cardiac allotransplantation.
Journal ArticleDOI
A convenient and highly enantioselective synthesis of (S)-2-pipecolic acid: an efficient access to caine anesthetics
TL;DR: In this paper, a novel and enantioselective synthesis of (S)-2-pipecolic acid (5) has been achieved from Oppolzer's sultam and ethyl N-(diphenylmethylene)glycinate as readily available starting materials.