Journal ArticleDOI
Structure of FK506, a novel immunosuppressant isolated from Streptomyces
Hirokazu Tanaka,Akio Kuroda,Hiroshi Marusawa,Hiroshi Hatanaka,Toru Kino,Toshio Goto,Masashi Hashimoto,Toru Taga +7 more
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This article is published in Journal of the American Chemical Society.The article was published on 1987-08-01. It has received 523 citations till now. The article focuses on the topics: Streptomyces tsukubaensis & Streptomyces.read more
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Journal ArticleDOI
Combined Application of Tacrolimus with Cyproconazole, Hymexazol and Novel {2-(3-R-1H-1,2,4-triazol-5-yl)phenyl}amines as Antifungals: In Vitro Growth Inhibition and In Silico Molecular Docking Analysis to Fungal Chitin Deacetylase
Lyudmyla M. Antypenko,Fatuma Meyer,Zhanar Sadyk,Konstyantyn Shabelnyk,Sergey I. Kovalenko,Karl G. Steffens,Leif-Alexander Garbe +6 more
TL;DR: In this paper , the authors used an in vitro growth assay to investigate the activity of the calcineurin inhibitor tacrolimus in combination with the commercial fungicides cyproconazole and hymexazol, as well as with two earlier reported novel {2-(3-R-1H-1,2,4-triazol-5-yl)phenylamines, against the fungi Aspergillus niger, Colletotrichum higginsianum, Fusarium oxysporum and the oomycete Phytophthora infestans, which are notoriously harmful in agriculture.
Journal ArticleDOI
Identification, characterization, and cloning of a novel aminoacylase, L-pipecolic acid acylase from Pseudomonas species
TL;DR: In this article, a novel L-aminoacylase, N-acetyl-L-pipecolic acid-specific amino acid acylase (LpipACY), from Pseudomonas sp. AK2 was isolated and characterized.
Journal ArticleDOI
Unmasking the True Identity of Rapamycin's Minor Conformer.
Emily B Crull,Ajay N. Jain,Paul C. D. Hawkins,Ann E. Cleves,Edmund I. Graziani,R. Thomas Williamson +5 more
TL;DR: The solution structure of the minor conformer of rapamycin was investigated using a combination of NMR techniques and computational methods and determined to be a trans amide species with rotation about the ester linkage as mentioned in this paper .
Book ChapterDOI
Discovery, Process Development, and Scale-Up of a Benzoxazepine-Containing mTor Inhibitor
Book ChapterDOI
Organic Synthesis Via Biocatalytic Methods — A Chemoenzymatic Approach to the Synthesis of FK506
Charles J. Sih,Rui-Lin Gu +1 more
TL;DR: A modular chemo-enzymatic strategy is used for the synthesis of the 23-membered macrolide FK506, which has been successfully prepared in their enantiomerically-pure forms using biocatalytic methodology.