Journal ArticleDOI
Structure of FK506, a novel immunosuppressant isolated from Streptomyces
Hirokazu Tanaka,Akio Kuroda,Hiroshi Marusawa,Hiroshi Hatanaka,Toru Kino,Toshio Goto,Masashi Hashimoto,Toru Taga +7 more
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This article is published in Journal of the American Chemical Society.The article was published on 1987-08-01. It has received 523 citations till now. The article focuses on the topics: Streptomyces tsukubaensis & Streptomyces.read more
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Copper‐Catalyzed Substrate‐Controlled Carbonylative Synthesis of α‐Keto Amides and Amides from Alkyl Halides
TL;DR: In this paper , a novel copper-catalyzed highly selective double carbonylation of alkyl bromides has been developed, and moderate to good yields of α-keto amides were obtained as the only products.
Dissertation
Chemical biology studies of neuroregenerative small molecules using Caenorhabditis elegans
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Cell detoxification of secondary metabolites by P4-ATPase-mediated vesicle transport
TL;DR: In this paper , the authors identify a P4-ATPase gene, BbCRPA, from the fungus Beauveria bassiana, which confers resistance via a unique vesicle mediated transport pathway that targets the compounds into detoxifying vacuoles.
Journal ArticleDOI
One-step Heck Reaction Generates Nonimmunosuppressive FK506 Analogs for Pharmacological BMP Activation
TL;DR: Structural-activity relationships provided novel mechanistic insights into the FK506-CN interaction that can be exploited for rational design of future analogs, and nonimmunosuppressive analogs of FK505 were generated using Heck reaction.
Antibody Catalysis of Some Organic and Biochemical Reactions
TL;DR: In the present investigation, structurally different antigens were used to study whether it was possible to obtain antibody catalysts for the acyl-transfer, Diels–Alder and peptidyl-prolyl cis-trans isomerisation reactions.