Journal ArticleDOI
Structure of FK506, a novel immunosuppressant isolated from Streptomyces
Hirokazu Tanaka,Akio Kuroda,Hiroshi Marusawa,Hiroshi Hatanaka,Toru Kino,Toshio Goto,Masashi Hashimoto,Toru Taga +7 more
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This article is published in Journal of the American Chemical Society.The article was published on 1987-08-01. It has received 523 citations till now. The article focuses on the topics: Streptomyces tsukubaensis & Streptomyces.read more
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Dermal targeting of tacrolimus using colloidal carrier systems.
TL;DR: Using colloidal carrier systems, the penetration profile of tacrolimus was enhanced significantly and high drug amounts penetrated the target site in a short period of time after applying the ME.
Journal ArticleDOI
Increased tacrolimus levels during diarrhea
Boris-W. Hochleitner,Claudia Bösmüller,Hermann Nehoda,Martin Frühwirt,Burkhard Simma,Helmut Ellemunter,W Steurer,Elisabeth-O. Hochleitner,Alfred Königsrainer,Raimund Margreiter +9 more
TL;DR: The tacrolimus trough levels of four male and two female recipients of solid organs before, during, and after gastroenteritis are measured to recommend that FK506 levels be carefully monitored during diarrhea in order to prevent intoxication.
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Purification of Crotonyl‐CoA Reductase from Streptomyces collinus and Cloning, Sequencing and Expression of the Corresponding Gene in Escherichia coli
Kimberlee K. Wallace,Zhuo‐Yao ‐Y Bao,Hong Dai,Russell J. DiGate,Gregory D. Schuler,Marilyn K. Speedie,Kevin A. Reynolds +6 more
TL;DR: Several dispersed regions of highly significant sequence similarity were noted between the deduced amino acid sequence and various alcohol dehydrogenases and fatty acid synthases, including one region that contains a putative NADPH binding site.
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Carbon source nutrition of rapamycin biosynthesis in Streptomyces hygroscopicus
TL;DR: Chemically-defined media were developed for rapamycin production by Streptomyces hygroscopicus and acetate and propionate, which are known to contribute most of the carbon atoms of the lactone ring, were unsatisfactory for growth and/or rap Amycin production.
Journal ArticleDOI
Rapamycin-inspired macrocycles with new target specificity.
Zufeng Guo,Sam Y. Hong,Jingxin Wang,Jingxin Wang,Shahid Rehan,Wukun Liu,Wukun Liu,Hanjing Peng,Manisha Das,Manisha Das,Wei Li,Wei Li,Shridhar Bhat,Brandon J. Peiffer,Brett R. Ullman,Chung Ming Tse,Zlatina Tarmakova,Cordelia Schiene-Fischer,Gunter Fischer,Imogen R. Coe,Ville O. Paavilainen,Zhaoli Sun,Jun O. Liu +22 more
TL;DR: A 45,000-compound macrocycle library has been synthesized by fusing oligopeptides with synthetic FKBP-binding domains, demonstrating that rapafucins are a new class of chemical probes and drug leads that can expand the repertoire of protein targets well beyond mTOR and calcineurin.