Journal ArticleDOI
Structure of FK506, a novel immunosuppressant isolated from Streptomyces
Hirokazu Tanaka,Akio Kuroda,Hiroshi Marusawa,Hiroshi Hatanaka,Toru Kino,Toshio Goto,Masashi Hashimoto,Toru Taga +7 more
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This article is published in Journal of the American Chemical Society.The article was published on 1987-08-01. It has received 523 citations till now. The article focuses on the topics: Streptomyces tsukubaensis & Streptomyces.read more
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Liquid chromatography-mass spectrometry characterization of FK506 biosynthetic intermediates in Streptomyces clavuligerus KCTC 10561BP.
TL;DR: This study developed a simple and highly selective method for detecting the biosynthetic intermediates involved in the FK506 pathway of Streptomyces clavuligerus KCTC 10561BP involving a cleanup procedure using a solid-phase extraction technique.
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The influence of lone-pair repulsions on C–C bond lengths: a critical evaluation of the experimental and theoretical evidence
TL;DR: In this article, negative hyperconjugative interaction between the oxygen lone pairs and the adjacent C-C σ* orbital is suggested to be the principal reason for the relatively long C−C bond in diketones.
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Activation of BMP Signaling by FKBP12 Ligands Synergizes with Inhibition of CXCR4 to Accelerate Wound Healing.
Brandon J. Peiffer,Le Qi,Ali Reza Ahmadi,Yuefan Wang,Zufeng Guo,Hanjing Peng,Zhaoli Sun,Jun O. Liu +7 more
TL;DR: It is raised the possibility that less toxic FKBP ligands such as FKVP can replace FK506 for the treatment of chronic wounds and selective inhibition of BMP signaling abolished stem cell recruitment and wound-healing enhancement by combination treatment.
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Visible‐Light Mediated Photooxidative Synthesis of α‐Keto Amides
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Cyclopropane Pipecolic Acids as Templates for Linear and Cyclic Peptidomimetics: Application in the Synthesis of an Arg-Gly-Asp (RGD)-Containing Peptide as an αvβ3 Integrin Ligand
Lorenzo Sernissi,Martina Petrović,Dina Scarpi,Antonio Guarna,Andrea Trabocchi,Francesca Bianchini,Ernesto G. Occhiato +6 more
TL;DR: CPAs appear to be suitable for the generation of novel peptidomimetics for drug discovery, particularly in a linear peptide sequence that bore the Arg-Gly-Asp (RGD) sequence.