Journal ArticleDOI
Superparamagnetic gadonanotubes are high-performance MRI contrast agents
Balaji Sitharaman,Kyle Kissell,Keith B. Hartman,Lesa A. Tran,A. Baikalov,Irene Rusakova,Y.Y. Sun,Htet A. Khant,Steven J. Ludtke,Wah Chiu,Sabrina Laus,Éva Tóth,Lothar Helm,Andre E. Merbach,Lon J. Wilson +14 more
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TLDR
This work reports the nanoscale loading and confinement of aquated Gd3+n-ion clusters within ultra-short single-walled carbon nanotubes (US-tubes) that are linear superparamagnetic molecular magnets with Magnetic Resonance Imaging (MRI) efficacies 40 to 90 times larger than any Gd 3+-based contrast agent (CA) in current clinical use.About:
This article is published in Chemical Communications.The article was published on 2005-07-29. It has received 315 citations till now.read more
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Current progress on the chemical modification of carbon nanotubes.
TL;DR: It is shown here how CNTs formed following Halogenation, followed by Direct Formation on Defect Sites, and the subsequent Encapsulation of Inorganic Substances led to the formation of CNT’s with Metal Nanoparticles.
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Carbon nanotube applications for tissue engineering.
TL;DR: Carbon nanotubes may play an integral role as unique biomaterial for creating and monitoring engineered tissue as well as imparting novel properties such as electrical conductivity into the scaffolds may aid in directing cell growth.
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Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers
TL;DR: This comprehensive review describes the state of the art of clinically approved contrast agents, their mechanism of action, and factors influencing their safety and efforts to make safer contrast agents either by increasing relaxivity, increasing resistance to metal ion release, or by moving to gadolinium(III)-free alternatives.
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Challenges for Molecular Magnetic Resonance Imaging
TL;DR: Challenges for CEST Agents and Hyperpolarized Probes: Use of Gd Contrast Agents with HyperPolarized Substances 3038.
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Macromolecules, Dendrimers, and Nanomaterials in Magnetic Resonance Imaging: The Interplay between Size, Function, and Pharmacokinetics
TL;DR: In this review, small molecule agents are introduced, but focus primarily on macromolecular MR contrast agents, particularly those containing gadolinium (Gd 3+ ) that are assembled or based in part on these same small molecules.
References
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Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications
TL;DR: A. Relaxivity 2331 E. Outerand Second-Sphere relaxivity 2334 F. Methods of Improving Relaxivity 2336 V. Macromolecular Conjugates 2336.
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Water conduction through the hydrophobic channel of a carbon nanotube
TL;DR: Observations suggest that carbon nanotubes, with their rigid nonpolar structures, might be exploited as unique molecular channels for water and protons, with the channel occupancy and conductivity tunable by changes in the local channel polarity and solvent conditions.
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Large-scale production of single-walled carbon nanotubes by the electric-arc technique
Catherine Journet,Wolfgang K. Maser,Patrick Bernier,A. Loiseau,M. Lamy de la Chapelle,Serge Lefrant,Philippe Deniard,R. S. Lee,John E. Fischer +8 more
TL;DR: In this article, it was shown that the growth mechanism for SWNTs must be independent of the details of the technique used to make them, and that the ready availability of large amounts of SWNT can make them much more accessible for further study.
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Magnetic nanoparticle design for medical diagnosis and therapy
TL;DR: A special emphasis is made on magnetic nanoparticle requirements from a physical viewpoint, the factors affecting their biodistribution and the solutions envisaged for enhancing their half-life in the blood compartment and targeting tumour cells.
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Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells.
TL;DR: In this paper, the interactions between various functionalized carbon nanotubes and several types of human cancer cells are explored. And they have shown that these can be derivatized in a way that enables attachment of small molecules and of proteins, the latter through a novel noncovalent association.