Open AccessJournal Article
Suppression of 7,12-Dimethylbenz(a)anthracene-induced Mammary Carcinogenesis in Rats by Resveratrol Role of Nuclear Factor-κB, Cyclooxygenase 2, and Matrix Metalloprotease 9
TLDR
Results suggest that resveratrol suppresses DMBA-induced mammary carcinogenesis, which correlates with down-regulation of NF-kappaB, cyclooxygenase-2, and matrix metalloprotease-9 expression.Abstract:
We have reported recently that resveratrol ( trans -3,4′,5-trihydroxystilbene), a polyphenolic phytoalexin found in grapes, fruits, and root extracts of the weed Polygonum cuspidatum , is a potent inhibitor of nuclear factor (NF)-κB activation. Because NF-κB suppression has been linked with chemoprevention, this prompted us to investigate the chemopreventive potential of resveratrol by testing it against mammary carcinogenesis induced by 7,12-dimethylbenz( a )anthracene (DMBA) in female Sprague Dawley rats. Dietary administration of resveratrol (10 ppm) had no effect on body weight gain and tumor volume but produced striking reductions in the incidence (45%; P P in situ (7 of 7), whereas treatment with resveratrol suppressed DMBA-induced ductal carcinoma. Immunohistochemistry and Western blot analysis revealed that resveratrol suppressed the DMBA-induced cyclooxygenase-2 and matrix metalloprotease-9 expression in the breast tumor. Gel shift analysis showed suppression of DMBA-induced NF-κB activation by resveratrol. Treatment of human breast cancer MCF-7 cells with resveratrol also suppressed the NF-κB activation and inhibited proliferation at S-G 2 -M phase. Overall, our results suggest that resveratrol suppresses DMBA-induced mammary carcinogenesis, which correlates with down-regulation of NF-κB, cyclooxygenase-2, and matrix metalloprotease-9 expression.read more
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Advances on Natural Polyphenols as Anticancer Agents for Skin Cancer.
Soraya Sajadimajd,Roodabeh Bahramsoltani,Roodabeh Bahramsoltani,Amin Iranpanah,Jayanta Kumar Patra,Gitishree Das,Sushanto Gouda,Roja Rahimi,Roja Rahimi,Elnaz Rezaeiamiri,Hui Cao,Francesca Giampieri,Maurizio Battino,Maurizio Battino,Rosa Tundis,Maria Gabriela Nogueira Campos,Mohammad Hosein Farzaei,Jianbo Xiao +17 more
TL;DR: Chemopreventive effects of polyphenols are mediated by several signaling pathways against skin carcinogenesis and metastasis, implying the importance ofpolyphenols to open up new horizons in development of anti-skin cancer therapeutic strategies.
Journal ArticleDOI
Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways
Bhupendra Singh,Rivka L. Shoulson,Anwesha Chatterjee,Amruta Ronghe,Nimee K. Bhat,Daniel C. Dim,Hari K. Bhat +6 more
TL;DR: It is suggested that Res inhibits E2-induced breast carcinogenesis via induction of NRF2-mediated protective pathways.
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Adolescent dietary phytoestrogen intake and breast cancer risk (Canada).
Joanne Thanos,Michelle Cotterchio,Michelle Cotterchio,Beatrice A. Boucher,Nancy Kreiger,Nancy Kreiger,Lilian U. Thompson +6 more
TL;DR: Higher phytoestrogen intake (both isoflavones and lignans) during adolescence was associated with a reduced breast cancer risk, and a monotonic trend was observed from the lowest to the highest quartile.
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Grape phytochemicals and associated health benefits.
Jun Yang,Yang-Yu Xiao +1 more
TL;DR: The aim of this paper is to critically review the most recent literature regarding the concentrations, biological activities, and mechanisms of grape phytochemicals.
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Resveratrol Prevents Epigenetic Silencing of BRCA-1 by the Aromatic Hydrocarbon Receptor in Human Breast Cancer Cells
TL;DR: The hypothesis that epigenetic silencing of the BRCA-1 gene by the AhR is preventable with Res is supported and provide the molecular basis for the development of dietary strategies based on natural AhR antagonists.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Mei-Shiang Jang,Lining Cai,George Udeani,Karla Slowing,Cathy F. Thomas,Chris Beecher,Harry H. S. Fong,Norman R. Farnsworth,A. Douglas Kinghorn,Rajendra G. Mehta,Richard C. Moon,John M. Pezzuto +11 more
TL;DR: It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
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Critique of Report on "Food, Nutrition and the Prevention of Cancer: A Global Perspective"
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