Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1.
Zhiping Liu,Jiaojiao Wang,Er-Wen Huang,Si Gao,Hong Li,Jing Lu,Kunming Tian,Peter J. Little,Xiaoyan Shen,Suowen Xu,Suowen Xu,Peiqing Liu +11 more
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TLDR
It is demonstrated that a novel HO-1-dependent mechanism is involved in the regulation of cholesterol balance by Tan, which reduces the content of macrophages, cholesterol accumulation, and the development of atherosclerotic plaque in apolipoprotein E-deficient mice.About:
This article is published in Journal of Lipid Research.The article was published on 2014-02-01 and is currently open access. It has received 75 citations till now. The article focuses on the topics: Foam cell & Scavenger receptor.read more
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Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics.
TL;DR: A systematic up-to-date review on the cardiovascular actions and therapeutic potential of major pharmacologically active constituents of Danshen and their bioactive compounds will serve as excellent drug candidates in small-molecule cardiovascular drug discovery.
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Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications.
TL;DR: The in vivo and in vitro studies showed that the tanshinone IIA and salvianolate have a wide range of cardiovascular and other pharmacological effects, including antioxidative, anti-inflammatory, endothelial protective, myocardial protective, anticoagulation, vasodilation, and anti-atherosclerosis.
Journal ArticleDOI
Atherogenesis and iron: from epidemiology to cellular level.
Francesca Vinchi,Martina U. Muckenthaler,Milene Costa da Silva,György Balla,György Balla,József Balla,Viktória Jeney,Viktória Jeney +7 more
TL;DR: This review article summarizes what the authors have learnt about iron and atherosclerosis from epidemiological studies, animal models and cellular systems and highlights the rather contributory than innocent role of iron in atherogenesis.
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Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products.
Dongdong Wang,Yang Yang,Yingnan Lei,Nikolay T. Tzvetkov,Xingde Liu,Andy Wai Kan Yeung,Suowen Xu,Atanas G. Atanasov +7 more
TL;DR: This review summarizes recent findings on the balanced effects of three major interrelated biologic processes, including lipid uptake, cholesterol esterification, and cholesterol efflux on foam cell formation and the development of foam cell-targeted therapeutic strategies.
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Tanshinones, Critical Pharmacological Components in Salvia miltiorrhiza.
TL;DR: This review will systematically present the composition, extraction and separation, pharmacological activities and biosynthesis of tanshinones from S. miltiorrhiza with the intent to provide references for studies on other terpenoid bioactive components of traditional Chinese medicines and to provide new research strategies for the sustainable development ofTraditional Chinese medicine resources.
References
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ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
TL;DR: The pathways that regulate ROS homeostasis are crucial for mitigating the toxicity of ROS and provide strong evidence about specificity in ROS signalling.
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A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Hiroshi Suzuki,Hiroshi Suzuki,Yukiko Kurihara,Motohiro Takeya,Nobuo Kamada,Motoyukl Kataoka,Kou-ichi Jishage,Otoya Ueda,Hisashl Sakaguchi,Takayuki Higashi,Tsukasa Suzuki,Yoshiaki Takashima,Yoshiki Kawabe,Yoshiki Kawabe,Osamu Cynshi,Youichiro Wada,Makoto Honda,Hiroki Kurihara,Hiroyuki Aburatani,Takefumi Doi,Akiyo Matsumoto,Sadahiro Azuma,Tetsuo Noda,Yutaka Toyoda,Hiroshige Itakura,Yoshio Yazaki,Seikoh Horiuchi,Kiyoshi Takahashi,J. Kar Kruijt,Theo J.C. Van Berkel,Urs P. Steinbrecher,Shun Ishibashi,Nobuyo Maeda,Siamon Gordon,Tatsuhiko Kodama +34 more
TL;DR: It is shown that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E, indicating that MSr-A may play a part in host defence against pathogens.
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Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
Maria Febbraio,Eugene A. Podrez,Jonathan D. Smith,David P. Hajjar,Stanley L. Hazen,Henry F. Hoff,Kavita Sharma,Roy L. Silverstein +7 more
TL;DR: Results support a major role for CD36 in atherosclerotic lesion development in vivo and suggest that blockade of CD36 can be protective even in more extreme proatherogenic circumstances.
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Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages
Vidya V. Kunjathoor,Maria Febbraio,Eugene A. Podrez,Kathryn J. Moore,Lorna P. Andersson,Stephanie L. Koehn,Jeongmi S. Rhee,Roy L. Silverstein,Henry F. Hoff,Mason W. Freeman +9 more
TL;DR: It is demonstrated that SR-A and CD36 are responsible for the preponderance of modified LDL uptake in macrophages and that other scavenger receptors do not compensate for their absence.
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ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation.
Matthew A. Kennedy,Gabriel C. Barrera,Kotoka Nakamura,Ángel Baldán,Paul T. Tarr,Michael C. Fishbein,Joy S. Frank,Omar L. Francone,Peter A. Edwards +8 more
TL;DR: It is demonstrated that the ABC transporter ABCG1 plays a critical role in lipid homeostasis by controlling both tissue lipid levels and the efflux of cellular cholesterol to HDL, and it is identified as a key gene involved in both cholesterol efflux to HDL and in tissue lipidHomeostasis.