Journal ArticleDOI
Targeted delivery of low molecular drugs using chitosan and its derivatives.
TLDR
The main objective of this review is to provide an insight into various target-specific carriers, based on chitosan and its derivatives, towards low molecular weight drug delivery.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2010-01-31. It has received 739 citations till now. The article focuses on the topics: Drug delivery & Targeted drug delivery.read more
Citations
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Chitosan—A versatile semi-synthetic polymer in biomedical applications
TL;DR: The chemical structure and relevant biological properties of chitosan for regenerative medicine have been summarized as well as the methods for the preparation of controlled drug release devices and their applications.
Journal ArticleDOI
Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.
TL;DR: The protective barrier properties of mucus secretions, how mucus affects the fate of orally administered nanoparticles, and recent developments in nanoparticles engineered to penetrate the mucus barrier are addressed.
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Block Copolymer Micelles in Nanomedicine Applications.
TL;DR: By shaping these features, polymeric micelles have been propitious for delivering a wide range of therapeutics through effective sensing of targets in the body and adjustment of their properties in response to particular stimuli, modulating the activity of the loaded drugs at the targeted sites, even at the subcellular level.
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Biological activities of chitosan and chitooligosaccharides
TL;DR: A review of chitosan and chitooligosaccharides can be found in this paper, where the authors focus on the biological properties of the compounds and their potential applications in the food, pharmaceutical, agricultural and environmental industries.
Journal ArticleDOI
Cationic polymers and their therapeutic potential
Sangram Keshari Samal,Mamoni Dash,Sandra Van Vlierberghe,David L. Kaplan,Emo Chiellini,Clemens van Blitterswijk,Lorenzo Moroni,Peter Dubruel +7 more
TL;DR: The most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications are reviewed.
References
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Cancer statistics, 2008.
Ahmedin Jemal,Rebecca L. Siegel,Elizabeth Ward,Yongping Hao,Jiaquan Xu,Taylor Murray,Michael J. Thun +6 more
TL;DR: This report examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, education, geographic area, and calendar year, as well as the proportionate contribution of selected sites to the overall trends.
Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
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TOPICAL REVIEW: Applications of magnetic nanoparticles in biomedicine
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The price of innovation: new estimates of drug development costs
TL;DR: The research and development costs of 68 randomly selected new drugs were obtained from a survey of 10 pharmaceutical firms and used to estimate the average pre-tax cost of new drug development.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.