Tendon injury and repair – A perspective on the basic mechanisms of tendon disease and future clinical therapy
Jess G. Snedeker,Jasper Foolen +1 more
TLDR
A novel framework to understand tendon physiology and pathophysiology is described that may be useful in pushing the field forward and represents a perspective on the important role that biomaterials will play in translating research discoveries to the patient.About:
This article is published in Acta Biomaterialia.The article was published on 2017-11-01 and is currently open access. It has received 238 citations till now. The article focuses on the topics: Tendon.read more
Citations
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Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis.
Eric Gracey,Arne Burssens,Arne Burssens,Isabelle Cambré,Isabelle Cambré,Georg Schett,Rik Lories,Iain B. McInnes,Hiroshi Asahara,Dirk Elewaut,Dirk Elewaut +10 more
TL;DR: The evidence for the known role of mechanical loading in tendinopathy and its potential role in inflammatory arthritis is discussed, which potentially focuses systemic autoimmune disease on the joint in the initiating phases of SpA and RA.
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Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies
TL;DR: The role of MSCs in boosting tendon regeneration, particularly through their capacity to enhance the tenogenic properties of tendon resident cells, is discussed, discussing the main challenges in the field of cell-based regenerative therapies.
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Melt electrowriting below the critical translation speed to fabricate crimped elastomer scaffolds with non-linear extension behaviour mimicking that of ligaments and tendons.
TL;DR: Direct-write cytocompatible fibres of a few micrometres thickness into crimp-structured elastomer scaffolds that mimic the non-linear biomechanical behaviour of tendon and ligament tissue.
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Oriented collagen fiber membranes formed through counter-rotating extrusion and their application in tendon regeneration.
TL;DR: The results verify the feasibility of the counter-rotating extrusion technology in fabricating biomimetic collagen scaffolds and provide a promising scaffold for tendon tissue regeneration.
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Anisotropic Hybrid Hydrogels with Superior Mechanical Properties Reminiscent of Tendons or Ligaments
TL;DR: This study suggests a new strategy for fabricating anisotropic hydrogels with superior mechanical properties to develop new biomaterials for artificial tendons or ligaments.
References
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Hydrogels for tissue engineering: scaffold design variables and applications.
Jeanie L. Drury,David J. Mooney +1 more
TL;DR: Hydrogels are an appealing scaffold material because they are structurally similar to the extracellular matrix of many tissues, can often be processed under relatively mild conditions, and may be delivered in a minimally invasive manner.
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Silk-based biomaterials
Gregory H. Altman,Frank Diaz,Caroline M. Jakuba,Tara Calabro,Rebecca L. Horan,Jingsong Chen,Helen H. Lu,John C. Richmond,David L. Kaplan +8 more
TL;DR: Studies with well-defined silkworm silk fibers and films suggest that the core silk fibroin fibers exhibit comparable biocompatibility in vitro and in vivo with other commonly used biomaterials such as polylactic acid and collagen.
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The Outcome and Repair Integrity of Completely Arthroscopically Repaired Large and Massive Rotator Cuff Tears
TL;DR: The minimum twelve-month evaluation showed excellent pain relief and improvement in the ability to perform activities of daily living despite the high rate of recurrent defects; however, at a minimum follow-up of two years, the results deteriorated with only twelve patients who had an American Shoulder and Elbow Surgeons score of >/=80.
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Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
TL;DR: The molecular mechanisms by which forces might act at a distance to induce mechanochemical conversion in the nucleus and alter gene activities are explored.
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Nuclear lamin-A Scales With Tissue Stiffness and Enhances Matrix-Directed Differentiation
Joe Swift,Irena L. Ivanovska,Amnon Buxboim,Takamasa Harada,P.C. Dave P. Dingal,Joel Pinter,J. David Pajerowski,Kyle R. Spinler,Jae-Won Shin,Manorama Tewari,Florian Rehfeldt,David W. Speicher,Dennis E. Discher,Dennis E. Discher +13 more
TL;DR: In this article, proteomics analyses revealed that levels of the nucleoskeletal protein lamin-A scaled with tissue elasticity, as did levels of collagens in the extracellular matrix that determine E.