Biologics for tendon repair.
TLDR
This review describes and critically assess the current strategies for enhancing tendon repair by biological means, mainly of applying growth factors, stem cells, natural biomaterials and genes, alone or in combination, to the site of tendon damage.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2015-04-01 and is currently open access. It has received 478 citations till now. The article focuses on the topics: Tendon.read more
Citations
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Tendon injury: from biology to tendon repair
TL;DR: Understanding the links between the mechanical and biological parameters involved in tendon development, homeostasis and repair is prerequisite for the identification of effective treatments for chronic and acute tendon injuries.
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Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies.
Heidi R. Hofer,Rocky S. Tuan +1 more
TL;DR: Future rational and effective MSC-based musculoskeletal therapies will benefit from better mechanistic understanding of MSC trophic activities, for example using analytical “-omics” profiling approaches.
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EGR1 Transcription Factor is a Multifaceted Regulator of Matrix Production in Tendons and Other Connective Tissues.
Emmanuelle Havis,Delphine Duprez +1 more
TL;DR: A recurring theme of EGR1 transcriptional activity in connective tissues, regulating genes related to the extracellular matrix is revealed.
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Gene therapy approaches to regenerating the musculoskeletal system
TL;DR: Gene transfer might improve repair and regeneration at sites of injury by enabling the local, sustained and potentially regulated expression of therapeutic gene products; such products include morphogens, growth factors and anti-inflammatory agents.
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The differential effects of leukocyte-containing and pure platelet-rich plasma (PRP) on tendon stem/progenitor cells - implications of PRP application for the clinical treatment of tendon injuries
TL;DR: L-PRP may be detrimental to the healing of injured tendons because it induces catabolic and inflammatory effects on tendon cells and may prolong the effects in healing tendons.
References
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc.
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Human mesenchymal stem cells modulate allogeneic immune cell responses
TL;DR: Insight is offered into the interactions between allogeneic MSCs and immune cells and mechanisms likely involved with the in vivo MSC-mediated induction of tolerance that could be therapeutic for reduction of GVHD, rejection, and modulation of inflammation.
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Resolution of inflammation: the beginning programs the end.
Charles N. Serhan,John Savill +1 more
TL;DR: Emerging evidence now suggests that an active, coordinated program of resolution initiates in the first few hours after an inflammatory response begins, and the mechanism required for inflammation resolution may underpin the development of drugs that can resolve inflammatory processes in directed and controlled ways.
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Mechanisms involved in the therapeutic properties of mesenchymal stem cells
Lindolfo da Silva Meirelles,Aparecida Maria Fontes,Dimas Tadeu Covas,Dimas Tadeu Covas,Arnold I. Caplan +4 more
TL;DR: Some of the molecules involved in the paracrine effects of MSCs are identified with a perspective that these cells intrinsically belong to a perivascular niche in vivo, and how this knowledge could be advantageously used in clinical applications is discussed.
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Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche
Yanming Bi,Driss Ehirchiou,Tina M. Kilts,Colette A. Inkson,Mildred C. Embree,Wataru Sonoyama,Li Li,Arabella I. Leet,Byoung Moo Seo,Li Zhang,Songtao Shi,Songtao Shi,Marian F. Young +12 more
TL;DR: It is shown that human and mouse tendons harbor a unique cell population, termed tendon stem/progenitor cells (TSPCs), that has universal stem cell characteristics such as clonogenicity, multipotency and self-renewal capacity and could regenerate tendon-like tissues after extended expansion in vitro and transplantation in vivo.