Journal ArticleDOI
Tenofovir-associated kidney toxicity in HIV-infected patients: a review of the evidence.
TLDR
The nature and extent of TDF-associated kidneyoxicity in the HIV-infected population, potential underlying mechanisms of toxicity in the proximal tubule, and risk factors for developing tubular dysfunction are discussed and suggested strategies to monitor patients on TDF therapy are suggested.About:
This article is published in American Journal of Kidney Diseases.The article was published on 2011-05-01. It has received 324 citations till now. The article focuses on the topics: Renal tubular dysfunction & Fanconi syndrome.read more
Citations
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Journal ArticleDOI
AASLD guidelines for treatment of chronic hepatitis B
Norah A. Terrault,Natalie Bzowej,Kyong-Mi Chang,Jessica P. Hwang,Maureen M. Jonas,M. Hassan Murad +5 more
TL;DR: Aasld Guidelines for Treatment of Chronic Hepatitis B Norah Terrault;Natalie Bzowej;Kyong-Mi Chang;Jessica Hwang;Maureen Jonas;Hassan Murad; Hepatology
Journal ArticleDOI
Association of tenofovir exposure with kidney disease risk in HIV infection.
Rebecca Scherzer,Michelle M. Estrella,Yongmei Li,Andy I. Choi,Steven G. Deeks,Carl Grunfeld,Michael G. Shlipak +6 more
TL;DR: Tenofovir exposure was independently associated with increased risk for three types of kidney disease events, and did not appear to be reversible.
Journal ArticleDOI
Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial
Maria Buti,Edward Gane,Wai-Kay Seto,Henry Lik-Yuen Chan,Wan-Long Chuang,Tatjana Stepanova,Aric J. Hui,Young-Suk Lim,R. Mehta,Harry L. A. Janssen,Subrat K. Acharya,John F. Flaherty,Benedetta Massetto,Andrea L. Cathcart,Kyungpil Kim,Anuj Gaggar,G. Mani Subramanian,John G. McHutchison,Calvin Q. Pan,Maurizia Rossana Brunetto,Namiki Izumi,Patrick Marcellin +21 more
TL;DR: The primary efficacy endpoint was the proportion of patients who had HBV DNA less than 29 IU/mL at week 48 in those who received at least one dose of study drug; the study was powered to show non-inferiority with a 10% efficacy margin of tenofovir alafenamide compared with ten ofovir disoproxil fumarate.
Journal ArticleDOI
Is HIV a Model of Accelerated or Accentuated Aging
TL;DR: The evidence that age-related clinical syndromes are exacerbated by HIV is outlined, the ways in which HIV is similar, and dissimilar from natural aging are examined, and the validity of HIV as a model of premature aging is assessed.
Journal ArticleDOI
96 weeks treatment of tenofovir alafenamide vs. tenofovir disoproxil fumarate for hepatitis B virus infection
Kosh Agarwal,Maurizia Rossana Brunetto,Wai-Kay Seto,Young-Suk Lim,Scott Fung,Patrick Marcellin,Sang Hoon Ahn,Namiki Izumi,Wan-Long Chuang,Ho Bae,Manoj Sharma,Harry L.A. Janssen,Harry L.A. Janssen,Calvin Q. Pan,Mustafa Kemal Çelen,Norihiro Furusyo,Shalimar,Ki Tae Yoon,Huy N. Trinh,John F. Flaherty,Anuj Gaggar,Audrey H. Lau,Andrea L. Cathcart,Lanjia Lin,Neeru Bhardwaj,Vithika Suri,G. Mani Subramanian,Edward Gane,Maria Buti,Henry Lik-Yuen Chan +29 more
TL;DR: In patients with HBV infection, TAF remained as effective as TDF, with continued improved renal and bone safety, two years after the initiation of treatment.
References
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Journal ArticleDOI
Assessing Kidney Function — Measured and Estimated Glomerular Filtration Rate
TL;DR: Current methods of measuring GFR and GFR-estimating equations and their strengths and weaknesses as applied to chronic kidney disease are considered.
Journal ArticleDOI
Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial.
Joel E. Gallant,Schlomo Staszewski,Anton Pozniak,Edwin DeJesus,Jamal M. A. H. Suleiman,Michael D. Miller,Dion F. Coakley,Biao Lu,John J. Toole,Andrew K. Cheng +9 more
TL;DR: Through 144 weeks, the combination of tenofovir DF, lamivudine, and efavirenz was highly effective and comparable with stavudine for antiretroviral-naive patients and appeared to be associated with better lipid profiles and less lipodystrophy.
Journal ArticleDOI
Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration
Caroline A. Sabin,Signe Westring Worm,Rainer Weber,Peter Reiss,Wafaa El-Sadr,François Dabis,Stéphane De Wit,Mathew M.G. Law,Antonella d'Arminio Monforte,Nina Friis-Møller,Ole Kirk,Christian Pradier,Ian V. D. Weller,Andrew N. Phillips,Jens D Lundgren +14 more
TL;DR: There exists an increased risk of myocardial infarction in patients exposed to abacavir and didanosine within the preceding 6 months and the excess risk does not seem to be explained by underlying established cardiovascular risk factors and was not present beyond 6 months after drug cessation.
Journal ArticleDOI
Tenofovir DF, Emtricitabine, and Efavirenz vs. Zidovudine, Lamivudine, and Efavirenz for HIV
Joel E. Gallant,Edwin DeJesus,Jose R. Arribas,Anton Pozniak,Brian Gazzard,Rafael Campo,Biao Lu,Damian J McColl,Steven L. Chuck,Jeffrey Enejosa,John J. Toole,Andrew K. Cheng +11 more
TL;DR: The combination of tenofovir DF and emtricitabineplus efavirenz fulfilled the criteria for noninferiority to a fixed dose of zidovudine and lamivudine plus efvirenz and proved superior in terms of virologic suppression, CD4 response, and adverse events resulting in discontinuation of the study drugs.
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Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomised, double-blind, phase 3, non-inferiority trials
Paul E. Sax,David A. Wohl,Michael Yin,Frank A. Post,Edwin DeJesus,Michael S. Saag,Anton Pozniak,Melanie Thompson,Daniel Podzamczer,Jean-Michel Molina,Shinichi Oka,Ellen Koenig,Benoit Trottier,Jaime Andrade-Villanueva,Gordon Crofoot,Joseph M. Custodio,Andrew Plummer,Lijie Zhong,Huyen Cao,Hal Martin,Christian Callebaut,Andrew K. Cheng,Marshall W. Fordyce,Scott McCallister +23 more