Journal ArticleDOI
The dendritic tree and brain disorders.
TLDR
This review discusses dendritic development and branching, and in specific, morphology, cytoskeletal architecture, and how the complexity of the dendrite tree and its functional capabilities are altered in various brain disorders.About:
This article is published in Molecular and Cellular Neuroscience.The article was published on 2012-05-01. It has received 336 citations till now. The article focuses on the topics: Dendrite morphogenesis & Dendritic spine.read more
Citations
More filters
Journal ArticleDOI
Dendritic Spines: The Locus of Structural and Functional Plasticity
Carlo Sala,Menahem Segal +1 more
TL;DR: Issues with respect to spine formation and plasticity are addressed and the complexity of molecular pathways involved in regulation of spine structure and function is highlighted, which contributes to the understanding of central synaptic interactions in health and disease.
Journal ArticleDOI
Molecular mechanisms of dendrite stability
TL;DR: New evidence reveals that dendritic spine and dendrite arbor stability have crucial roles in the correct functioning of the adult brain and that loss of stability is associated with psychiatric disorders and neurodegenerative diseases.
Journal ArticleDOI
Stress, anxiety, and dendritic spines: What are the connections?
Benedetta Leuner,Tracey J. Shors +1 more
TL;DR: The reciprocal relationships between the expression of stress- and anxiety-related behaviors and stress-induced morphological plasticity as detected by changes in dendrites and spines in brain regions known to be involved in anxiety are reviewed.
Journal ArticleDOI
Development of Dendritic Form and Function
TL;DR: The mechanisms that regulate the construction of cell type-specific dendrite patterns during development are reviewed, focusing on four aspects of dendritic patterning that are particularly important in determining the function of the mature neuron.
Journal ArticleDOI
The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines.
Manav Pathania,Elizabeth C. Davenport,James Muir,David F. Sheehan,Guillermo López-Doménech,Josef T. Kittler +5 more
TL;DR: Evidence is provided that dysregulation of CYFIP1 expression levels leads to pathological changes in CNS maturation and neuronal connectivity, both of which may contribute to the development of the neurological symptoms seen in ASD and SCZ.
References
More filters
Journal ArticleDOI
Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment.
Robert D. Terry,Eliezer Masliah,David P. Salmon,Nelson Butters,Richard DeTeresa,Robert Hill,Lawrence A. Hansen,Robert Katzman +7 more
TL;DR: Both linear regressions and multivariate analyses correlating three global neuropsychological tests with a number of structural and neurochemical measurements performed on a prospective series of patients with Alzheimer's disease and 9 neuropathologically normal subjects reveal very powerful correlations with all three psychological assays.
Journal ArticleDOI
Alzheimer's Disease Is a Synaptic Failure
TL;DR: Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β protein.
Journal ArticleDOI
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
Annemiske J.M.H. Verkerk,Maura Pieretti,James S. Sutcliffe,Ying-Hui Fu,Derek P.A. Kuhl,Antonio Pizzuti,Orly Reiner,Stephen Richards,Maureen F. Victoria,Fuping Zhang,Bert Eussen,Gert-Jan B. van Ommen,Lau Blonden,Gregory J. Riggins,Jane L. Chastain,Catherine B. Kunst,Hans Galjaard,C. Thomas Caskey,David L. Nelson,Ben A. Oostra,Stephen T. Warren +20 more
TL;DR: A fragile X site-induced breakpoint cluster region that exhibits length variation in fragile X chromosomes is identified and localization of the brain-expressed FMR-1 gene to this EcoRI fragment suggests the involvement of this gene in the phenotypic expression of the fragile X syndrome.
Journal ArticleDOI
Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.
TL;DR: This review examines the evidence for hippocampal atrophy in Cushing syndrome, which is characterized by a pathologic oversecretion of glucocorticoids; (2) episodes of repeated and severe major depression; (3) posttraumatic stress disorder and what cellular mechanisms underlie the overall decreases in hippocampal volume.
Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.