Journal ArticleDOI
The development of candidate composite disease activity and responder indices for psoriatic arthritis (GRACE project)
Philip S. Helliwell,Philip S. Helliwell,Oliver FitzGerald,Jaap Fransen,Dafna D. Gladman,Gerald G Kreuger,Kristina Callis-Duffin,Neil McHugh,Philip J. Mease,Vibeke Strand,Robin Waxman,Valderílio Feijó Azevedo,Adriana Beltran Ostos,Sueli Carneiro,Alberto Cauli,Luis R Espinoza,John A. Flynn,Nada Hassan,Paul J. Healy,Eduardo Kerzberg,Yun Jong Lee,Ennio Lubrano,Antonio Marchesoni,Helena Marzo-Ortega,Giovanni Porru,Elvia G. Moreta,Peter Nash,Helena Raffayova,Roberto Ranza,Siba P. Raychaudhuri,Euthalia Roussou,Raphael Scarpa,Yeong Wook Song,Enrique R. Soriano,Paul P. Tak,Ilona Ujfalussy,Kurt de Vlam,Jessica A. Walsh +37 more
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TLDR
Two new composite measures to assess disease activity in PsA have been developed by multiple linear regression and empirically, utilising physician-defined cut-offs for disease activity, and area under the receiver operating curves (AUC) were generally smaller.Abstract:
Objective To develop new composite disease activity indices for psoriatic arthritis (PsA). Methods Data from routine clinic visits at multiple centres were collected in a systematic manner. Data included all domains identified as important in randomised controlled trials in PsA. Decisions to change treatment were used as surrogates for high disease activity. New indices were developed by multiple linear regression (psoriatic arthritis disease activity score: PASDAS) and empirically, utilising physician-defined cut-offs for disease activity (arithmetic mean of desirability functions: AMDF). These were compared with existing composite measures: Composite Psoriatic arthritis Disease Activity Index (CPDAI), Disease Activity for PSoriatic Arthritis (DAPSA), and Disease Activity Score for rheumatoid arthritis (DAS28). Results 161/503 (32%) subjects had treatment changes. Although all measures performed well, compared with existing indices, PASDAS was better able to discriminate between high and low disease activity (area under receiver operating curves (ROC)) curve with 95% CI: PASDAS 0.773 (0.723, 0.822); AMDF 0.730 (0.680, 0.780); CPDAI 0.719 (0.668, 0.770); DAPSA 0.710 (0.654, 0.766); DAS28 0.736 (0.680, 0.792). All measures were able to discriminate between disease activity states in patients with oligoarthritis, although area under the receiver operating curves (AUC) were generally smaller. In patients with severe skin disease (psoriasis area and severity index >10) both nonparametric and AUC curve statistics were nonsignificant for all measures. Conclusions Two new composite measures to assess disease activity in PsA have been developed. Further testing in other datasets, including comparison with existing measures, is required to validate these instruments.read more
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Journal ArticleDOI
Biomarkers: project update from the GRAPPA 2012 annual meeting.
TL;DR: The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis is now ready to commence formal negotiations with potential funding partners and intends to initiate this project in the near future.
Journal ArticleDOI
Composite Measures of Disease Activity in Psoriatic Arthritis: Comparative Instrument Performance Based on the Efficacy of Guselkumab in an Interventional Phase II Trial
P S Helliwell,Atul Deodhar,Alice B. Gottlieb,Wolf-Henning Boehncke,Xie L. Xu,Stephen Xu,Y. Wang,Elizabeth C. Hsia,Dafna D. Gladman,Christopher T. Ritchlin +9 more
TL;DR: To assess performance of psoriatic arthritis (PsA) composite indices and evaluate guselkumab’s effect on achieving low disease activity or remission, three new drugs are introduced and one is withdrawn for unclear reasons.
Journal ArticleDOI
The GOLMePsA study protocol: an investigator-initiated, double-blind, parallel-group, randomised, controlled trial of GOLimumab and methotrexate versus methotrexate in early diagnosed psoriatic arthritis using clinical and whole body MRI outcomes
Gabriele De Marco,Gabriele De Marco,Philip S. Helliwell,Philip S. Helliwell,Dennis McGonagle,Dennis McGonagle,Paul Emery,Paul Emery,Laura C. Coates,Laura C. Coates,Elizabeth M A Hensor,Elizabeth M A Hensor,Helena Marzo-Ortega +12 more
TL;DR: The hypothesis underlining this study is that very early treatment with first-line GOL reduces disease activity in PsA, in comparison to conventional therapy.
Journal ArticleDOI
Measuring Outcomes in Psoriatic Arthritis.
TL;DR: This article will review the key measures for assessment of PsA and focus primarily on measures with a sufficient body of evidence for the instrument and will use the GRAPPA-OMERACT Core Outcome Set to walk through instruments to measure these domains.
Journal ArticleDOI
Effectiveness of steroid injection for hand psoriatic dactylitis: results from a multicentre prospective observational study.
Nicolò Girolimetto,Pierluigi Macchioni,Giorgia Citriniti,Ilaria Tinazzi,Vittoria Bascherini,Federica Martinis,Antonio Marchetta,Niccolò Possemato,Marco Tasso,Rosario Peluso,Leonardo Punzi,Carlo Salvarani,Raffaele Scarpa,Dennis McGonagle,Luisa Costa,Francesco Caso +15 more
TL;DR: Therapy with steroid injection into the digital flexor tendon sheath for the treatment of active dactylitis in psoriatic arthritis patients, is more effective when compared with systemic treatment (ST) alone.
References
More filters
Journal ArticleDOI
Measurement of patient outcome in arthritis.
TL;DR: A structure for representation of patient outcome is presented, together with a method for outcome measurement and validation of the technique in rheumatoid arthritis, and these techniques appear extremely useful for evaluation of long term outcome of patients with rheumatic diseases.
Journal ArticleDOI
Severe psoriasis--oral therapy with a new retinoid.
T. Fredriksson,Ulf Pettersson +1 more
TL;DR: Ro 10--9359 proved to be an extremely potent antipsoriatic drug and a more than 90% reduction of psoriatic lesions could be seen in 10 patients out of 20 after 4-8 weeks of treatment.
Journal ArticleDOI
Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis: comparison with the preliminary American College of Rheumatology and the World Health Organization/International League Against Rheumatism criteria
A.M. van Gestel,M.L.L. Prevoo,M.A. van 't Hof,M. H. Van Rijswijk,L. B. A. Van De Putte,P.L.C.M. van Riel +5 more
TL;DR: EULAR response criteria showed better construct and discriminant validity than did the ACR and the WHO/ILAR response criteria for RA and the World Health Organization and International League Against Rheumatism criteria.
Journal ArticleDOI
Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial
TL;DR: Etanercept offers patients with psoriatic arthritis and psoriasis a new therapeutic option for control of their disease.
Journal Article
Defining spinal mobility in ankylosing spondylitis (AS). The Bath AS Metrology Index
TL;DR: Five clinical measurements provide a composite index (BASMI) and define disease status in AS, which is quick, reproducible and sensitive to change across the disease spectrum.
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