Journal ArticleDOI
The development of candidate composite disease activity and responder indices for psoriatic arthritis (GRACE project)
Philip S. Helliwell,Philip S. Helliwell,Oliver FitzGerald,Jaap Fransen,Dafna D. Gladman,Gerald G Kreuger,Kristina Callis-Duffin,Neil McHugh,Philip J. Mease,Vibeke Strand,Robin Waxman,Valderílio Feijó Azevedo,Adriana Beltran Ostos,Sueli Carneiro,Alberto Cauli,Luis R Espinoza,John A. Flynn,Nada Hassan,Paul J. Healy,Eduardo Kerzberg,Yun Jong Lee,Ennio Lubrano,Antonio Marchesoni,Helena Marzo-Ortega,Giovanni Porru,Elvia G. Moreta,Peter Nash,Helena Raffayova,Roberto Ranza,Siba P. Raychaudhuri,Euthalia Roussou,Raphael Scarpa,Yeong Wook Song,Enrique R. Soriano,Paul P. Tak,Ilona Ujfalussy,Kurt de Vlam,Jessica A. Walsh +37 more
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Two new composite measures to assess disease activity in PsA have been developed by multiple linear regression and empirically, utilising physician-defined cut-offs for disease activity, and area under the receiver operating curves (AUC) were generally smaller.Abstract:
Objective To develop new composite disease activity indices for psoriatic arthritis (PsA). Methods Data from routine clinic visits at multiple centres were collected in a systematic manner. Data included all domains identified as important in randomised controlled trials in PsA. Decisions to change treatment were used as surrogates for high disease activity. New indices were developed by multiple linear regression (psoriatic arthritis disease activity score: PASDAS) and empirically, utilising physician-defined cut-offs for disease activity (arithmetic mean of desirability functions: AMDF). These were compared with existing composite measures: Composite Psoriatic arthritis Disease Activity Index (CPDAI), Disease Activity for PSoriatic Arthritis (DAPSA), and Disease Activity Score for rheumatoid arthritis (DAS28). Results 161/503 (32%) subjects had treatment changes. Although all measures performed well, compared with existing indices, PASDAS was better able to discriminate between high and low disease activity (area under receiver operating curves (ROC)) curve with 95% CI: PASDAS 0.773 (0.723, 0.822); AMDF 0.730 (0.680, 0.780); CPDAI 0.719 (0.668, 0.770); DAPSA 0.710 (0.654, 0.766); DAS28 0.736 (0.680, 0.792). All measures were able to discriminate between disease activity states in patients with oligoarthritis, although area under the receiver operating curves (AUC) were generally smaller. In patients with severe skin disease (psoriasis area and severity index >10) both nonparametric and AUC curve statistics were nonsignificant for all measures. Conclusions Two new composite measures to assess disease activity in PsA have been developed. Further testing in other datasets, including comparison with existing measures, is required to validate these instruments.read more
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Journal ArticleDOI
Reduced joint counts misclassify patients with oligoarticular psoriatic arthritis and miss significant numbers of patients with active disease.
Laura C. Coates,Oliver FitzGerald,Dafna D. Gladman,Neil McHugh,Philip J. Mease,Vibeke Strand,Philip S. Helliwell +6 more
TL;DR: Patients with oligoarticular PsA cannot be accurately assessed for active disease using reduced joint counts designed for RA, and full 66/68-joint counts should be performed to assess patients with PsA.
Journal ArticleDOI
Comparing patient-perceived and physician-perceived remission and low disease activity in psoriatic arthritis: an analysis of 410 patients from 14 countries
Clémence Gorlier,Ana Maria Orbai,Déborah Puyraimond-Zemmour,Laura C. Coates,Uta Kiltz,Ying Ying Leung,Penelope Esther Palominos,Juan D. Cañete,Rossana Scrivo,Andra Balanescu,Emmanuelle Dernis,Sandra Tälli,Adeline Ruyssen-Witrand,Martin Soubrier,Sibel Zehra Aydin,Lihi Eder,Inna Gaydukova,Ennio Lubrano,Umut Kalyoncu,Pascal Richette,M. Elaine Husni,Maarten de Wit,Josef S Smolen,Laure Gossec +23 more
TL;DR: DAPSA-based remission/LDA performed better than VLDA/MDA to detect patient-defined remission or remission-defined LDA, and remission/ LDA was frequently attained in this unselected population.
Journal ArticleDOI
The 12-item Psoriatic Arthritis Impact of Disease Questionnaire: Construct Validity, Reliability, and Interpretability in a Clinical Setting
Marco Di Carlo,Andrea Becciolini,Valentina Lato,Chiara Crotti,Ennio Giulio Favalli,Fausto Salaffi +5 more
TL;DR: The PsAID-12 is an excellent PRO to evaluate the effect of PsA and should be carefully handled in patients with coexisting FM.
Journal ArticleDOI
Minimal Disease Activity as a Treatment Target in Psoriatic Arthritis: A Review of the Literature.
Laure Gossec,Dennis McGonagle,Tatiana Korotaeva,Ennio Lubrano,Eugenio de Miguel,Mikkel Østergaard,Frank Behrens +6 more
TL;DR: The frequencies of MDA achievement with biologic disease-modifying antirheumatic drugs are summarized based on data from registries, observational studies, and clinical trials.
Journal ArticleDOI
Clinical Features of Psoriatic Arthritis: a Comprehensive Review of Unmet Clinical Needs
TL;DR: The biomarker development process is examined, the importance of qualifying unmet clinical needs is highlighted, the need to develop minimally invasive tests predictive of diagnosis, response to treatment and radiographic progression is highlighted and the challenges that impede biomarker studies are emphasised.
References
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