Journal ArticleDOI
The development of candidate composite disease activity and responder indices for psoriatic arthritis (GRACE project)
Philip S. Helliwell,Philip S. Helliwell,Oliver FitzGerald,Jaap Fransen,Dafna D. Gladman,Gerald G Kreuger,Kristina Callis-Duffin,Neil McHugh,Philip J. Mease,Vibeke Strand,Robin Waxman,Valderílio Feijó Azevedo,Adriana Beltran Ostos,Sueli Carneiro,Alberto Cauli,Luis R Espinoza,John A. Flynn,Nada Hassan,Paul J. Healy,Eduardo Kerzberg,Yun Jong Lee,Ennio Lubrano,Antonio Marchesoni,Helena Marzo-Ortega,Giovanni Porru,Elvia G. Moreta,Peter Nash,Helena Raffayova,Roberto Ranza,Siba P. Raychaudhuri,Euthalia Roussou,Raphael Scarpa,Yeong Wook Song,Enrique R. Soriano,Paul P. Tak,Ilona Ujfalussy,Kurt de Vlam,Jessica A. Walsh +37 more
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TLDR
Two new composite measures to assess disease activity in PsA have been developed by multiple linear regression and empirically, utilising physician-defined cut-offs for disease activity, and area under the receiver operating curves (AUC) were generally smaller.Abstract:
Objective To develop new composite disease activity indices for psoriatic arthritis (PsA). Methods Data from routine clinic visits at multiple centres were collected in a systematic manner. Data included all domains identified as important in randomised controlled trials in PsA. Decisions to change treatment were used as surrogates for high disease activity. New indices were developed by multiple linear regression (psoriatic arthritis disease activity score: PASDAS) and empirically, utilising physician-defined cut-offs for disease activity (arithmetic mean of desirability functions: AMDF). These were compared with existing composite measures: Composite Psoriatic arthritis Disease Activity Index (CPDAI), Disease Activity for PSoriatic Arthritis (DAPSA), and Disease Activity Score for rheumatoid arthritis (DAS28). Results 161/503 (32%) subjects had treatment changes. Although all measures performed well, compared with existing indices, PASDAS was better able to discriminate between high and low disease activity (area under receiver operating curves (ROC)) curve with 95% CI: PASDAS 0.773 (0.723, 0.822); AMDF 0.730 (0.680, 0.780); CPDAI 0.719 (0.668, 0.770); DAPSA 0.710 (0.654, 0.766); DAS28 0.736 (0.680, 0.792). All measures were able to discriminate between disease activity states in patients with oligoarthritis, although area under the receiver operating curves (AUC) were generally smaller. In patients with severe skin disease (psoriasis area and severity index >10) both nonparametric and AUC curve statistics were nonsignificant for all measures. Conclusions Two new composite measures to assess disease activity in PsA have been developed. Further testing in other datasets, including comparison with existing measures, is required to validate these instruments.read more
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Journal ArticleDOI
Actualización en artritis psoriásica
A. López-Ferrer,A. Laiz-Alonso +1 more
TL;DR: Se ha puesto de manifiesto la necesidad de disponer de metodos de cribado fiables, en especial para identificar precozmente las formas oligoarticulares, y establecer criterios de derivacion practicos that permitan ofrecer una atencion espe specializada.
Journal ArticleDOI
Sustained and improved guselkumab response in patients with active psoriatic arthritis regardless of baseline demographic and disease characteristics: pooled results through week 52 of two phase III, randomised, placebo-controlled studies
Christopher T. Ritchlin,Philip J. Mease,Wolf-Henning Boehncke,John Tesser,Elena Schiopu,Soumya D. Chakravarty,A. Kollmeier,Xie L. Xu,May Shawi,Yusang Jiang,Shihong Sheng,Yanli Wang,Stephen Xu,Joseph F. Merola,Iain B. McInnes,Atul Deodhar +15 more
TL;DR: Guselkumab Q4W and Q8W resulted in robust and sustained improvements in PsA signs and symptoms consistently in subgroups of patients defined by diverse baseline characteristics.
Journal ArticleDOI
Comparing methotrexate monotherapy with methotrexate plus leflunomide combination therapy in psoriatic arthritis: protocol of a randomized, placebo-controlled, double-blind clinical trial (COMPLETE-PsA).
Michelle L M Mulder,Johanna E. Vriezekolk,Nathan den Broeder,Elien A. M. Mahler,Philip S. Helliwell,Frank H J van den Hoogen,Alfons A den Broeder,Mark H. Wenink +7 more
TL;DR: This is the first randomized, placebo-controlled, double-blind clinical trial assessing the effectiveness of MTX and LEF combination therapy in patients with PsA and it will provide important information for treatment strategies and treatment recommendations.
Journal ArticleDOI
Disease activity indices in psoriatic arthritis: current and evolving concepts.
TL;DR: Several indices have been proposed over the last years, each of them considering different combinations of disease characteristics as discussed by the authors, each of which has specific pros and cons, and each of these indices has specific strengths and weaknesses.
Journal ArticleDOI
Development of a Modified Psoriatic Arthritis Disease Activity Score Using the Medical Outcomes Study Short Form 12 as a Measure of Quality of Life.
TL;DR: A modified PASDAS was investigated, which substituted the SF‐36 with the shortened SF‐12, and the agreement between the PASdAS and a modified mPASDas was found to be satisfactory.
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