Journal ArticleDOI
The development of candidate composite disease activity and responder indices for psoriatic arthritis (GRACE project)
Philip S. Helliwell,Philip S. Helliwell,Oliver FitzGerald,Jaap Fransen,Dafna D. Gladman,Gerald G Kreuger,Kristina Callis-Duffin,Neil McHugh,Philip J. Mease,Vibeke Strand,Robin Waxman,Valderílio Feijó Azevedo,Adriana Beltran Ostos,Sueli Carneiro,Alberto Cauli,Luis R Espinoza,John A. Flynn,Nada Hassan,Paul J. Healy,Eduardo Kerzberg,Yun Jong Lee,Ennio Lubrano,Antonio Marchesoni,Helena Marzo-Ortega,Giovanni Porru,Elvia G. Moreta,Peter Nash,Helena Raffayova,Roberto Ranza,Siba P. Raychaudhuri,Euthalia Roussou,Raphael Scarpa,Yeong Wook Song,Enrique R. Soriano,Paul P. Tak,Ilona Ujfalussy,Kurt de Vlam,Jessica A. Walsh +37 more
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TLDR
Two new composite measures to assess disease activity in PsA have been developed by multiple linear regression and empirically, utilising physician-defined cut-offs for disease activity, and area under the receiver operating curves (AUC) were generally smaller.Abstract:
Objective To develop new composite disease activity indices for psoriatic arthritis (PsA). Methods Data from routine clinic visits at multiple centres were collected in a systematic manner. Data included all domains identified as important in randomised controlled trials in PsA. Decisions to change treatment were used as surrogates for high disease activity. New indices were developed by multiple linear regression (psoriatic arthritis disease activity score: PASDAS) and empirically, utilising physician-defined cut-offs for disease activity (arithmetic mean of desirability functions: AMDF). These were compared with existing composite measures: Composite Psoriatic arthritis Disease Activity Index (CPDAI), Disease Activity for PSoriatic Arthritis (DAPSA), and Disease Activity Score for rheumatoid arthritis (DAS28). Results 161/503 (32%) subjects had treatment changes. Although all measures performed well, compared with existing indices, PASDAS was better able to discriminate between high and low disease activity (area under receiver operating curves (ROC)) curve with 95% CI: PASDAS 0.773 (0.723, 0.822); AMDF 0.730 (0.680, 0.780); CPDAI 0.719 (0.668, 0.770); DAPSA 0.710 (0.654, 0.766); DAS28 0.736 (0.680, 0.792). All measures were able to discriminate between disease activity states in patients with oligoarthritis, although area under the receiver operating curves (AUC) were generally smaller. In patients with severe skin disease (psoriasis area and severity index >10) both nonparametric and AUC curve statistics were nonsignificant for all measures. Conclusions Two new composite measures to assess disease activity in PsA have been developed. Further testing in other datasets, including comparison with existing measures, is required to validate these instruments.read more
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Predicting functional disability in patients with spondyloarthritis using a CRP-based algorithm: A 3-year prospective study.
L. Catan,Marius Boariu,Elena Amaricai,Daniel Popa,G. Puenea,Mihai Drăgoi,Ștefan Ioan Stratul,Razvan Dragoi +7 more
TL;DR: This derived algorithm based on objective CRP assessment may have implications in the prediction of functional disability evolution in patients with SpA.
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Value of ultrasound examination of the Leeds Enthesitis Index in assessment of disease activity in psoriatic arthritis
TL;DR: This study aimed to determine the added value of the US assessment of enthesitis according to LEI over the clinical assessment in determination of PsA activity.
Journal ArticleDOI
The association between sonographic enthesitis with sonographic synovitis and tenosynovitis in psoriatic arthritis patients.
Victoria Furer,Jonathan Wollman,David Levartovsky,Valerie Aloush,Ofir Elalouf,H. Sarbagil-Maman,Liran Mendel,Sara Borok,Daphna Paran,Ori Elkayam,Ari Polachek +10 more
TL;DR: In this paper , the authors examined the association between enthesitis with sonographic synovitis and tenosynovitis in psoriatic arthritis (PsA) patients.
Journal ArticleDOI
The Psoriatic Arthritis 5-Thermometer Scales (PsA-5Ts): Measurement Properties of a New Multidimensional Composite Tool for the Quick Assessment of the Overall Health Status in Psoriatic Arthritis
TL;DR: In this paper , the authors evaluated the clinimetric properties of the Psoriatic Arthritis 5-Thermometer Scales (PsA-5Ts), a new patient-reported outcome (PRO) to measure the overall health status in PsA patients.
Journal ArticleDOI
A new integral enthesial-comorbididity index of psoriatic arthritis activity
Yu. O. Korsakova,Tatiana Korotaeva,Elena Loginova,E. Gubar,L. D. Vorobyeva,Svetlana Glukhova,Evgeny Nasonov +6 more
TL;DR: In this article , an integral index of psoriatic arthritis (PsA) activity was developed, based on Parametric and nonparametric statistic methods, correlation and ROC analysis were used.
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Defining spinal mobility in ankylosing spondylitis (AS). The Bath AS Metrology Index
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