The Genomic Architecture and Evolutionary Fates of Supergenes.
TLDR
In this paper, the authors synthesize recent genomic work and historical models of supergene evolution, highlighting how the genomic architecture of supergenes affects their evolutionary fate, and use forward simulations to demonstrate that differences in genomic architecture affect the degeneration of super-genes.Abstract:
Supergenes are genomic regions containing sets of tightly linked loci that control multi-trait phenotypic polymorphisms under balancing selection. Recent advances in genomics have uncovered significant variation in both the genomic architecture as well as the mode of origin of supergenes across diverse organismal systems. Although the role of genomic architecture for the origin of supergenes has been much discussed, differences in the genomic architecture also subsequently affect the evolutionary trajectory of supergenes and the rate of degeneration of supergene haplotypes. In this review, we synthesize recent genomic work and historical models of supergene evolution, highlighting how the genomic architecture of supergenes affects their evolutionary fate. We discuss how recent findings on classic supergenes involved in governing ant colony social form, mimicry in butterflies, and heterostyly in flowering plants relate to theoretical expectations. Furthermore, we use forward simulations to demonstrate that differences in genomic architecture affect the degeneration of supergenes. Finally, we discuss implications of the evolution of supergene haplotypes for the long-term fate of balanced polymorphisms governed by supergenes.read more
Citations
More filters
Journal ArticleDOI
Supergene origin and maintenance in Atlantic cod
Michael Matschiner,Julia Maria Isis Barth,Ole K. Tørresen,Bastiaan Star,Helle Tessand Baalsrud,Marine S. O. Brieuc,Christophe Pampoulie,Ian Bradbury,Kjetill S. Jakobsen,Sissel Jentoft +9 more
TL;DR: This article investigated the origin and maintenance of four megabase-scale supergenes through analysis of whole-genome-sequencing data, including a new long-read-based genome assembly for a non-migratory Atlantic cod individual.
Journal ArticleDOI
Supergene origin and maintenance in Atlantic cod
Michael Matschiner,Julia Maria Isis Barth,Ole K. Tørresen,Bastiaan Star,Helle Tessand Baalsrud,Marine S. O. Brieuc,Christophe Pampoulie,Ian Bradbury,Kjetill S. Jakobsen,Sissel Jentoft +9 more
TL;DR: This paper investigated the origin and maintenance of four megabase-scale supergenes through analysis of whole-genome-sequencing data, including a new long-read-based genome assembly for a non-migratory Atlantic cod individual.
Journal ArticleDOI
A supergene underlies linked variation in color and morphology in a Holarctic songbird
Erik R. Funk,Nicholas A. Mason,Snæbjörn Pálsson,Tomáš Albrecht,Tomáš Albrecht,Jeffrey A. Johnson,Scott A. Taylor +6 more
TL;DR: Acanthis et al. as mentioned in this paper used genome sequences to investigate the genetic basis of phenotypic variation in redpoll finches and found that variation in the redpoll phenotype is broadly controlled by a ~55-Mb chromosomal inversion.
Journal ArticleDOI
Comparative Genomics Elucidates the Origin of a Supergene Controlling Floral Heteromorphism
Giacomo Potente,Étienne Léveillé-Bourret,Narjes Yousefi,Rimjhim Roy Choudhury,Barbara Keller,Seydina Issa Diop,Danny Duijsings,Walter Pirovano,Michael Lenhard,Péter Szövényi,Elena Conti +10 more
TL;DR: The present study presents the first chromosome-scale genome assembly of any heterostylous species, that of Primula veris (cowslip), and demonstrates that the S-locus evolved via multiple, asynchronous gene duplications and independent gene translocations.
Journal ArticleDOI
OUP accepted manuscript
TL;DR: In this paper , the first chromosome-scale genome assembly of any heterostylous species, that of Primula veris (cowslip), was presented, and the authors demonstrated that the S-locus evolved via multiple, asynchronous gene duplications and independent gene translocations.
References
More filters
Journal ArticleDOI
Mutation load at a mimicry supergene sheds new light on the evolution of inversion polymorphisms.
Paul Jay,Mathieu Chouteau,Mathieu Chouteau,Annabel Whibley,Héloïse Bastide,Hugues Parrinello,Violaine Llaurens,Mathieu Joron +7 more
TL;DR: In this article, the authors show that despite a strong selective advantage when they form, inversions accumulate recessive deleterious mutations that generate frequency-dependent selection and promote their maintenance at intermediate frequency.
Journal ArticleDOI
The fire ant social chromosome supergene variant Sb shows low diversity but high divergence from SB.
TL;DR: It is shown that the Sb haplotype of the supergene region has 635‐fold less nucleotide diversity than the rest of the genome, and how this reduction could be due to a recent selective sweep affecting Sb specifically or associated with a population bottleneck during the invasion of North America by the sampled population is discussed.
Journal ArticleDOI
A shared genetic basis of mimicry across swallowtail butterflies points to ancestral co-option of doublesex.
TL;DR: It is concluded that mimicry evolution in this group was likely facilitated by ancestral polymorphism resulting from early co-option of dsx as a mimicry locus, and that evolutionary turnover ofdsx alleles may underlie the wing pattern diversity of extant polymorphic and monomorphic lineages.
Journal ArticleDOI
An Ancient and Eroded Social Supergene Is Widespread across Formica Ants
Alan Brelsford,Alan Brelsford,Jessica Purcell,Jessica Purcell,Amaury Avril,Patrick Tran Van,Junxia Zhang,Junxia Zhang,Timothée Brütsch,Liselotte Sundström,Heikki Helanterä,Michel Chapuisat +11 more
TL;DR: The discovery that a very small portion of this large and ancient supergene harbors conserved trans-species SNPs linked to colony social organization suggests that the ancestral haplotypes have been eroded by recombination, with selection preserving differentiation at one or a few genes generating alternative social organization.
Journal ArticleDOI
A new recombinant in the heteromorphy ‘S’ supergene in Primula
Valsa Kurian,A J Richards +1 more
TL;DR: It is shown for the first time in Primula the independence of pollen size from male incompatibility, and that pollen size is under gametophytic control, dominance for this character being controlled by a recombinable locus.