The Genomic Architecture and Evolutionary Fates of Supergenes.
TLDR
In this paper, the authors synthesize recent genomic work and historical models of supergene evolution, highlighting how the genomic architecture of supergenes affects their evolutionary fate, and use forward simulations to demonstrate that differences in genomic architecture affect the degeneration of super-genes.Abstract:
Supergenes are genomic regions containing sets of tightly linked loci that control multi-trait phenotypic polymorphisms under balancing selection. Recent advances in genomics have uncovered significant variation in both the genomic architecture as well as the mode of origin of supergenes across diverse organismal systems. Although the role of genomic architecture for the origin of supergenes has been much discussed, differences in the genomic architecture also subsequently affect the evolutionary trajectory of supergenes and the rate of degeneration of supergene haplotypes. In this review, we synthesize recent genomic work and historical models of supergene evolution, highlighting how the genomic architecture of supergenes affects their evolutionary fate. We discuss how recent findings on classic supergenes involved in governing ant colony social form, mimicry in butterflies, and heterostyly in flowering plants relate to theoretical expectations. Furthermore, we use forward simulations to demonstrate that differences in genomic architecture affect the degeneration of supergenes. Finally, we discuss implications of the evolution of supergene haplotypes for the long-term fate of balanced polymorphisms governed by supergenes.read more
Citations
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Ecological basis and genetic architecture of crypsis polymorphism in the desert clicker grasshopper (Ligurotettix coquilletti).
Timothy K. O’Connor,Timothy K. O’Connor,Marissa C. Sandoval,Jiarui Wang,Jacob C. Hans,Risa Takenaka,Risa Takenaka,Myron Child,Noah K. Whiteman +8 more
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Supergene degeneration opposes polymorphism: The curious case of balanced lethals
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Genomic analyses of the <i>Linum</i> distyly supergene reveal convergent evolution at the molecular level
TL;DR: In this article , the authors characterized the genetic architecture and evolution of the distyly supergene in Linum by generating a chromosome-level genome assembly of Linum tenue , followed by the identification of the S-locus using population genomic data.
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TL;DR: In this paper , the pericentromeric regions of the oyster plant are homogenized in concert by three subtelomeric sequences: 45S rDNA, (TTTAGGG)n motif, and TSrepI repeat.
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Weak antagonistic fitness effects can maintain an inversion polymorphism
TL;DR: In this paper , the maintenance of an inversion polymorphism that links 250 genes on chromosome Tgu11 in the zebra finch (Taeniopygia guttata) was studied.
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