The Genomic Architecture and Evolutionary Fates of Supergenes.
TLDR
In this paper, the authors synthesize recent genomic work and historical models of supergene evolution, highlighting how the genomic architecture of supergenes affects their evolutionary fate, and use forward simulations to demonstrate that differences in genomic architecture affect the degeneration of super-genes.Abstract:
Supergenes are genomic regions containing sets of tightly linked loci that control multi-trait phenotypic polymorphisms under balancing selection. Recent advances in genomics have uncovered significant variation in both the genomic architecture as well as the mode of origin of supergenes across diverse organismal systems. Although the role of genomic architecture for the origin of supergenes has been much discussed, differences in the genomic architecture also subsequently affect the evolutionary trajectory of supergenes and the rate of degeneration of supergene haplotypes. In this review, we synthesize recent genomic work and historical models of supergene evolution, highlighting how the genomic architecture of supergenes affects their evolutionary fate. We discuss how recent findings on classic supergenes involved in governing ant colony social form, mimicry in butterflies, and heterostyly in flowering plants relate to theoretical expectations. Furthermore, we use forward simulations to demonstrate that differences in genomic architecture affect the degeneration of supergenes. Finally, we discuss implications of the evolution of supergene haplotypes for the long-term fate of balanced polymorphisms governed by supergenes.read more
Citations
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Genomic evidence supports genetic convergence of a supergene controlling the distylous floral syndrome.
Zhongtao Zhao,Yu Zhang,Miaomiao Shi,Zhao-Ying Liu,Yuanqing Xu,Zhonglai Luo,Shuai Yuan,Tu Tieyao,Zhi-Liang Sun,Dianxiang Zhang,Spencer C. H. Barrett +10 more
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Cryptic recessive lethality of a supergene controlling social organization in ants
Pierre Blacher,Ornela De Gasperin,Guglielmo Grasso,Solenn Sarton‐Lohéac,Roxane Allemann,Michel Chapuisat +5 more
TL;DR: In the Alpine silver ant, Formica selysi, a large and ancient social supergene with two haplotypes, M and P, controls colony social organization as discussed by the authors .
Posted ContentDOI
Low mutation load in a supergene underpinning alternative male mating strategies in ruff
Jason Joseph Hill,Erik D Enbody,Huijuan Bi,Sangeet Lamichhaney,Doreen Schwochow,Shady Younis,Fredrik Widemo,Leif Andersson +7 more
TL;DR: The results suggest that the inversion inuffs may be much younger than previously thought and the lack of mutation load despite recessive lethality can be explained by the introgression of the inversions from a now extinct lineage.
Journal ArticleDOI
Functional unit of supergene in female-limited Batesian mimicry of Papilio polytes.
TL;DR: In Papilio polytes, female-limited Batesian mimicry is thought to be regulated by a ∼130kb inversion region (highly diversified region: HDR) containing three genes, UXT, U3X and doublesex (dsx) which switches non-mimetic and mimetic types as discussed by the authors .
Posted ContentDOI
Ecological basis and genetic architecture of crypsis polymorphism in the desert clicker grasshopper (Ligurotettix coquilletti)
Timothy K. O’Connor,Timothy K. O’Connor,Marissa C. Sandoval,Jiarui Wang,Jacob C. Hans,Risa Takenaka,Risa Takenaka,Myron Child,Noah K. Whiteman +8 more
TL;DR: In this article, the authors found that banded and uniform morphs of the desert clicker grasshopper (Ligurotettix coquilletti) are found across the western deserts of North America.
References
More filters
Journal ArticleDOI
Comprehensive mapping of long-range interactions reveals folding principles of the human genome.
Erez Lieberman Aiden,Nynke L. van Berkum,Louise Williams,Maxim Imakaev,Tobias Ragoczy,Tobias Ragoczy,Agnes Telling,Agnes Telling,Ido Amit,Bryan R. Lajoie,Peter J. Sabo,Michael O. Dorschner,Richard Sandstrom,Bradley E. Bernstein,Bradley E. Bernstein,Michaël Bender,Mark Groudine,Mark Groudine,Andreas Gnirke,John A. Stamatoyannopoulos,Leonid A. Mirny,Eric S. Lander,Eric S. Lander,Job Dekker +23 more
TL;DR: Hi-C is described, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing and demonstrates the power of Hi-C to map the dynamic conformations of entire genomes.
Journal ArticleDOI
The hitch-hiking effect of a favourable gene.
John Maynard Smith,John Haigh +1 more
TL;DR: If the selective coefficients at the linked locus are small compared to those at the substituted locus, it is shown that the probability of complete fixation at the links is approximately exp (− Nc), where c is the recombinant fraction and N the population size.
Journal ArticleDOI
The relation of recombination to mutational advance.
TL;DR: It is shown that this calculation does not apply for mutant genes that act advantageously only when in some special combinations with one or more other mutant genes, and that as far as these cases of special synergism are concerned recombining lines have no evolutionary advantage over non-recombining ones.
Journal ArticleDOI
The effect of deleterious mutations on neutral molecular variation.
TL;DR: Observed reductions in molecular variation in low recombination genomic regions of sufficiently large size, for instance in the centromere-proximal regions of Drosophila autosomes or in highly selfing plant populations, may be partly due to background selection against deleterious mutations.